Apolipoprotein E genotype and deposits of Aβ40 and Aβ42 in Alzheimer disease

Archives of Neurology

Volumn 55, Issue 7, 1998, Pages 1001-1004

  McNamara, Megan J ^a   Gomez Isla, Teresa ^b   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ARTICLE; GENE; GENE MUTATION; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; RISK FACTOR; TEMPORAL LOBE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; APOLIPOPROTEINS E; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEUROPEPTIDES; PEPTIDE FRAGMENTS; SENILE PLAQUES;

EID: 0031866674     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.55.7.1001     Document Type: Article

References (28)

1. Sherrington R, Rogaev E, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzneimer's disease. Nature. 1995;375:754-760.
2. Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 1995;269:973-977.
3. Goate A, Chartier-Harlin M, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 1991;349:704-706.
4. Tamaoka A, Odaka A, Ishibashi Y, et al. APP717 missense mutation affects the ratio of amyloid β protein species (Aβ1-42/43 and Aβ1-40) in familial Alzheimer's disease brain. J Biol Chem. 1994;269:32721-32724.
5. Borchelt D, Thinakaran G, Eckman C, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron. 1996; 17:1005-1013.
6. Citron M, Westaway D, Xia W, et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β protein in both transfected cells and transgenic mice. Nat Med. 1997;3:67-72.
7. Tomita T, Maruyama K, Saldo T, et al. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci U S A. 1997;94:2025-2030.
8. Duff K, Eckman C, Zehr C, et al. Increased amyloid-β 42(43) in brains of mice expressing mutant presenilin 1. Nature. 1996;383:710-713.
9. Gomez-Isla T, Wasco W, Pettingell W, et al. A novel presenilin 1 mutation: increased β-amyloid and neurofibrillary changes. Ann Neurol. 1997;41:809-813.
10. Mann D, Iwatsubo T, Cairns N, et al. Amyloid β protein (Aβ) deposition in chromosome 14-linked Alzheimer's disease: predominance of Aβ42(43). Ann Neurol. 1996;40:149-156.
11. Kosaka T, Imagawa M, Seki K, et al. The βAPP717 Alzheimer mutation increases the percentage of plasma amyloid-β protein ending at Aβ42(43). Neurology. 1997;48:741-745.
12. Iwatsubo T, Mann D, Odaka A, Suzuki N, Ihara Y. Amyloid β protein (Aβ) deposition: Aβ 42(43) precedes Aβ 40 in Down syndrome. Ann Neurol. 1995;37:294-299.
13. Iwatsubo T, Odaka A, Suziiki N, Mizusawa H, Nukina N, Ihara Y. Visualization of Aβ 42(43) and Aβ 40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ 42(43). Neuron. 1995;13:45-53.
14. Jarrett J, Berger E, Lansbury PJ. The carboxy terminus of the β amyloid protein is critical for the seeding of the amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry. 1993;32:4693-4697.
15. Rebeck G, Reiter J, Strickland D, Hyman B. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron. 1993;11:575-580.
16. Saunders A, Strittmatter W, Schmechel D, et al. Association of apolipoprotein E allele ∈4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993;43:1467-1472.
17. Strittmatter W, Saunders A, Schmechel D, et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90:1977-1981.
18. Corder E, Saunders A, Risch N, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet. 1994;7:180-184.
19. Hyman B, Gomez-lsla T, Rebeck G, et al. Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease. Ann N Y Acad Sci. 1996;802:1-5.
20. Schmechel D, Saunders A, Strittmatter W, et al. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90:9649-9653.
21. Gearing M, Mori H, Mirra S. Aβ-peptide length and apolipoprotein E genotype in Alzheimer's disease. Ann Neurol. 1996;39:395-399.
22. Mann D, Iwatsubo T, Pickering-Brown S, Owen F, Saido T, Perry R. Preferential deposition of amyloid β protein (Aβ) in the form Aβ40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele. Neurosci Lett. 1997;221:81-84.
23. Hyman B, Tanzi R, Marzloff K, et al. Kunitz protease inhibitor containing amyloid precursor protein immunoreactivity in Alzheimer's disease: a quantitative study. J Neuropathol Exp Neurol. 1992;51:76-83.
24. Yeterian E, Pandya D. Architecture and Connections of Cortical Association Areas. New York, NY: Plenum Publishing Corp: 1985:3-6. Peters A, Jones EG, eds. Cerebral Cortex: Association and Auditory Cortices; vol 4.
25. Yeterian E, Pandya D. Architecture and Connections of Cortical Association Areas. New York, NY: Plenum Publishing Corp: 1985:3-6. Peters A, Jones EG, eds. Cerebral Cortex: Association and Auditory Cortices; vol 4.
26. Arnold S, Hyman B, Flory J, et al. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in cerebral cortex of patients with Alzheimer's disease. Cerebral Cortex. 1991;1:103-116.
27. Arriagada P, Growdon J, Hedley-Whyte E, Hyman B. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology. 1992;42:631-639.
28. Ishii K, Tamaoka A, Mizusawa H, et al. Aβ1-40 but not Aβ1-42 levels in cortex correlate with apolipoprotein E ∈4 allele dosage in sporadic Alzheimer's disease. Brain Res. 1997;748:250-252.