Development of a freeze-dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration

S.T.P. Pharma Sciences

Volumn 9, Issue 5, 1999, Pages 429-436

  Fernandez Urrusuno, R ^a   Romani, D ^a   Calvo, P ^a   Vila Jato, J L ^a   Alonso, M J ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Chitosan nanoparticles; Freeze drying; Insulin; Nasal administration

Indexed keywords

CHITOSAN; DEXTRAN; GLUCOSE; INSULIN; LIPOSOME; NANOPARTICLE; SUCROSE; TREHALOSE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; FREEZE DRYING; GLUCOSE BLOOD LEVEL; INSULIN TREATMENT; MALE; NONHUMAN; RABBIT; THERMAL ANALYSIS; ZETA POTENTIAL;

EID: 0033300109     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Development of new chitosan-cellulose multicore microparticles for controlled drug delivery
2. Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
3. Polymeric chitosan-based vesicles for drug delivery
4. Effect of acid type, acetic acid and sodium carboxymethyl cellulose concentrations on the formation, micromeritic, dissolution and floating porperties of theophylline chitosan microcapsules
5. Chitosan as a novel nasal delivery system for peptide drugs
6. Preparation of chitosan microspheres containing fluorouracil using the dry-in-oil method and its release characteristics
7. Chitosan and its use as a pharmaceutical excipient
8. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
9. Mucoadhesive polymers in peroral peptide delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo
10. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
11. Chitosan as a nasal delivery system: Evaluation of insulin absorption and effect on nasal membrane integrity using rat models
12. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines
13. Oligonucleotide-chitosan nanoparticles as new gene therapy vector
14. Preparation and evaluation of methotrexate-O-carboxymethylated chitosan nanoparticles. Application of nanoparticles to controlled release anticancer drugs
15. Release behaviour of 5-fluorouracil from chitosan-gel nanospheres immobilizing 5-fluorouracil coated with polysaccharides and their cell specific cytotoxicity
16. Develpment of a new non-surgical perfusion technique for evaluation of nasal drug delivery
17. Investigation of the effect of anaesthesia on nasal absorption of insulin in rats
18. Measurement of glass transition temperatures of freeze-concentrated solutes by differential scanning calorimetry
19. Enhancement of nasal absorption of insulin using chitosan nanoparticles
20. Microsphere absorption by the nasal mucosa of the rat
21. Immune response to nasal delivery of antigenically intact tetanus toxoid associated to poly(L-lactic acid) microspheres in rats, rabbits and guinea-pigs
22. Stealth PLA-PEG nanoparticles as protein carriers for nasal administration