Chitinosans as tableting excipients for modified release delivery systems

International Journal of Pharmaceutics

Volumn 181, Issue 1, 1999, Pages 49-60

  Rege, Pankaj R ^a   Shukla, Dhruti J ^a   Block, Lawrence H ^a  

^a Dept of Med Chem and Pharmaceut   (United States)

Author keywords

Chitinosan; Chitosan; Excipient; Polyelectrolyte complex

Indexed keywords

CHITIN; CHITOSAN; EXCIPIENT; POLYELECTROLYTE;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG RELEASE; NONHUMAN; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET MATRIX;

ACETYLATION; ACETYLGLUCOSAMINE; ANALYSIS OF VARIANCE; CARBOHYDRATE SEQUENCE; CHITIN; COMPRESSIVE STRENGTH; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; EXCIPIENTS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; SALICYLIC ACID; TABLETS;

EID: 0032956741     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00416-5     Document Type: Article

References (12)

1. Akbuga J. A biopolymer: chitosan. Int. J. Pharm. Adv. 1:1995;3-18.
2. Al-Angary A.A. Effects of molecular weight and particle size of chitosan on chlorpheniramine maleate release from compressed tablets. Saudi Pharm. J. 2:1994;157-162.
3. Austin P.R., Brine, C.J., 1981. Chitin powder and process for making it. US Patent 4,286,087, 25 August.
4. Block L.H., 1997. Chitinosans: enabling excipients for drug delivery systems. Internationales Symposium: Chitin/Chitosan Isolierung, Charakterisierung, Anwendung. Lübeck, Germany, 19-20 July.
5. Gordon R.E., Rosanske T.W., Fonner D.E., Anderson N.R., Banker G.S. Granulation technology and tablet characterization. Liebermann H.A., Lachman L., Schwartz J.B. Pharmaceutical Dosage Forms: Tablets. 2:1990;245-348 Marcel Dekker, New York.
6. Knapczyk J. Excipient ability of chitosan for direct tableting. Int. J. Pharm. 89:1993;1-7.
7. Lehr C., Bouwstra J.A., Schacht E.H., Junginger H. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm. 78:1992;43-48.
8. Machida Y., Nagai T. Chitin/chitosan as pharmaceutical excipients. Breimer D.D., Crommelin D.J.A., Midha K.K. Topics in Pharmaceutical Sciences. 1989;211-220 F. I. P, The Hague.
9. Sabnis S.S., 1996. Development of modified chitosans as excipients for use in drug delivery systems, Ph.D. Thesis. Duquesne University, USA, pp. 127-132.
10. Sabnis S.S., Block L.H. Improved infrared spectroscopic method for the analysis of degree of N-deacetylation of chitosan. Polymer Bull. 39:1997;67-71.
11. Sabnis S.S., Rege P.R., Block L.H. Use of chitosan in compressed tablets of diclofenac sodium: inhibition of drug release in an acidic environment. Pharm. Dev. Tech. 2:1997;243-255.
12. Schipper N.G.M., Vårum K.M., Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs. 1. Influence of molecular weight and degree of deacetylation on drug transport across human intestinal epithelial (Caco-2) cells. Pharm. Res. 13:1996;1686-1692.