Effect of chitosan and chitosan glutamate enhancing the dissolution properties of the poorly water soluble drug nifedipine

International Journal of Pharmaceutics

Volumn 175, Issue 1, 1998, Pages 75-84

  Portero, A ^a   Remunan Lopez C ^a   Vila Jato, J L ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Chitosan; Chitosan glutamate; Co ground mixture; Dissolution enhancement; Nifedipine; Solid dispersion

Indexed keywords

CHITOSAN; CHITOSAN DERIVATIVE; NIFEDIPINE;

ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG GRANULATION; DRUG MIXTURE; DRUG SOLUBILITY; PRIORITY JOURNAL; TECHNIQUE; WETTABILITY;

EID: 0345195980     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00245-2     Document Type: Article

References (23)

1. Acartürk, F., Sencan, A., Celebi, N., 1993. Enhancement of the dissolution of spironolactone with chitosan and low-molecular weight gelatin. STP Pharma Sci. 3, 369-373.
2. Adusumilli, P.S., Bolton, S.M., 1991. Evaluation of chitosan citrate complexes as matrices for controlled release formulations using a 32 full factoral design. Drug Dev. Ind. Pharm. 17, 1931-1945.
3. Borchard, G., Lueßen, H.L., de Boer, A.G., Coos Verhoef, J., Lehr, C.M., Junginger, H.E., 1996. The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III - Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J. Control. Release 39, 131-138.
4. Genta, I., Pavanetto, F., Conti, B., Giunchedi, P., Conte, U., 1995. Improvement of dexamethasone dissolution rate from spray-dried chitosan microspheres. STP Pharma Sci. 5, 202-207.
5. Hirano, S., Seino, H., Akiyama, I., Nonaka, I., 1990. Chitosan - a biocompatible material for oral and intravenous administrations. In: Gebelein, C.G., Dunn, R.L. (Eds.), Progress in Biomedical Polymers. Plenum Press, New York, pp. 283-289.
6. Illum, L., Farraj, N.F., Davis, S.S., 1994. Chitosan as a novel nasal delivery system for peptide drugs. Pharm. Res. 11, 1186-1189.
7. Imai, T., Shiraishi, S., Saito, H., Otagiri, M., 1991. Interaction of indomethacin with low-molecular weight chitosan and improvement of some pharmaceutical properties of indomethacin by low-molecular weight chitosans. Int. J. Pharm. 67, 11-20.
8. Khan, K.A., 1975. The concept of dissolution efficiency. J. Pharm. Pharmacol. 27, 48-49.
9. Lehr, C.M., Bouwstra, J.A., Schacht, E.H., Junginger, H.E., 1992. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm. 78, 43-48.
10. Morimoto, K., Tabata, H., Morisaka, K., 1987. Nasal absorption of nifedipine from gel preparations in rats. Chem. Pharm. Bull. 35, 3041-3044.
11. Muzarelli, R.A.A., 1977. Chitin. Pergamon, Oxford.
12. Nagai, T., Sawayanagi, Y., Nambu, N., 1984. Application of chitin and chitosan to pharmaceutical preparations. In: Zizakis, J.P. (Ed.), Chitin, Chitosan and Related Enzymes. Academic Press, Orlando, FL, pp. 21-39.
13. Nogami, H., Nagai, T., Yotsuyanagi, I., 1969. Dissolution phenomena of organic medicinals involving simultaneous phase changes. Chem. Pharm. Bull. 17, 499-509.
14. Sawayanagi, Y., Nambu, N., Nagai, T., 1982. Enhancement of dissolution properties of griseofulvin from ground mixtures with chitin or chitosan. Chem. Pharm. Bull. 30, 4464-4467.
15. Sawayanagi, Y., Nambu, N., Nagai, T., 1983. Dissolution properties and bioavailability of phenytoin from ground mixtures with chitin or chitosan. Chem. Pharm. Bull. 31, 2064-2068.
16. Shiraishi, S., Arahira, M., Imai, T., Otagiri, M., 1990. Enhancement of dissolution rates of several drugs by low-molecular weight chitosan and alginate. Chem. Pharm. Bull. 38, 185-189.
17. Sugimoto, I., Kuchiki, A., Nakagawa, H., Tohgo, K., Kondo, S., Iwane, I., Takahashi, K., 1980. Dissolution and absorption of nifedipine from nifedipine-polyvinylpyrrolidone coprecipitates. Drug. Dev. Ind. Pharm. 6, 137-160.
18. Sumnu, M., 1986. Increasing dissolution rate and gastrointestinal absorption of nifedipine via solid dispersion. STP Pharma Sci. 2, 214-220.
19. Syed Laik Ali, 1989. Nifedipine. In: Florey, K. (Ed.), Analytical Profiles of Drug Substances, vol. 18, Academic Press, New York, pp. 221-289.
20. Torres-Labandeira, J.J., Remuñán-López, C., Echezarreta-López, M., Vila Jato, J.L., 1992. Use of cyclodextrins in sustained-release nifedipine formulations. In: Hedges, A.R. (Ed.), Minutes of the Sixth International Symposium on Cyclodextrins. Editions de Santé, Paris, pp. 563-566.
21. Upadrashta, S.M., Katikaneni, P.R., Nuessle, N.O., 1992. Chitosan as a tablet binder. Drug Dev. Ind. Pharm. 18, 1701-1708.
22. Wan, L.S.C., Pang, E.P.L., 1995. Action of carriers on drug dissolution. STP Pharma Sci. 5, 134-138.
23. Weiner, M.L., 1993. An overview of the regulatory status and of the safety of chitin and chitosan as food and pharmaceutical ingredients. In: Brine, C.J., Sandford, P.A., Zizakis, J.P. (Eds.), Advances in Chitin and Chitosan. Elsevier, London, pp. 663-672.