Chemotropic molecules as a mechanism for the orientation of axon growth and nerve migration during the development of the nervous system of mammals;Moléculas quimiotrópicas como mecanismo de orientación del crecimiento axonal y de la migración neuronal durante el desarrollo del sistema nervioso de los mamíferos

Revista de Neurologia

Volumn 33, Issue 1, 2001, Pages 54-68

  De Castro, F ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Axon growth; Chemotropism; Nerve migration; Netrines; Neuroembryology; Semaphorines; Slits

Indexed keywords

CELL ADHESION MOLECULE; CHEMOTACTIC PEPTIDE; NETRIN; NEUROPILIN; OSTEOGENIC PROTEIN 1; REELIN; RETINOIC ACID; SCATTER FACTOR; SEMAPHORIN; SONIC HEDGEHOG PROTEIN;

CELL MIGRATION; CHEMOTAXIS; EMBRYO DEVELOPMENT; GROWTH REGULATION; HISTORY OF MEDICINE; HYPOTHESIS; MOLECULAR BIOLOGY; NERVE FIBER GROWTH; NERVE GROWTH; NERVOUS SYSTEM DEVELOPMENT; REVIEW;

EID: 0034807881     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3301.2001100     Document Type: Review

References (188)

1. The molecular biology of axon guidance
2. Sobre la aparición de las expansiones celulares en la médula embrionaria
3. A quelle époque apparaissent les expansions des cellules nerveuses de la moelle épinière du poulet
4. The outgrowth of the nerve fiber as a mode of protoplasmic movement
5. On the origin and development of the nervous system studied by the methods of experimental embryology. The Croonian Lecture
6. Growth cone guidance: First steps towards a deeper understanding
7. Signal transduction underlying growth cone guidance by diffusible factors
8. Facial visceral motor neurons display specific rhombomere origin and axon pathfinding behavior in the chick
9. La retine des vertébrés
10. Note on regeneration of pre-ganglionic fibres of the sympathetic
11. In vitro experiments on the factors determining the course of the outgrowing nerve fiber
12. Nerve patterns: Mechanics of nerve growth
13. Chemoaffinity in the orderly growth of nerve fiber patterns and connections
14. Cell adhesion molecule expression and the regulation of morphogenesis
15. Possible roles for a cell-to-substratum adhesion in neuronal morphogenesis
16. Cell-to-substratum adhesion and guidance of axonal elongation
17. Chemotropic guidance of developing axons in the mammalian nervous system
18. Chemorepulsion of axons in the developing mammalian central nervous system
19. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
20. The netrins define a family of axon-promoting proteins homologous to C. Elegans UNC-6
21. Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord
22. Synaptic activity and the construction of cortical circuits
23. Mice lacking specific nicotinic acetylcholine receptor subunits exhibit dramatically altered spontaneous activity patterns and reveal a limited role for retinal waves in forming ON and OFF circuits in the inner retina
24. Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice
25. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation
26. Spatial distributions of guidance molecules regulate chemorepulsion and chemoattraction of growth cones
27. Mathematical guidance for axons
28. Theoretical analysis of gradient detection by growth cones
29. Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axons
30. Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling
31. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules
32. Neuropilin-2, a novel member of the Neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III
33. Unified nomenclature for the semaphorins/collapsins
34. Neuropilin is a receptor for the axonal chemorepellent semaphorin III
35. Neuropilin is a semaphorin III receptor
36. Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ
37. Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively
38. Roles of a neuronal cell-surface molecule, neuropilin, in nerve fiber fasciculation and guidance
39. Semaphorins and their receptors in vertebrates and invertebrates
40. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors
41. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates
42. Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A
43. Olfactory sensory axons expressing a dominant-negative semaphorin receptor enter the CNS early and over-shoot their target
44. Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema 3A and L1 signaling pathways in axonal guidance
45. Determination of cell adhesion sites of neuropilin-1
46. Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones
47. Neuropilin-1 is expressed on adult mammalian dorsal root ganglion neurons and mediates semaphorin3a/Collapsin-1-induced growth cone collapse by small diameter sensory afferents
48. Neurotrophins rapidly modulate growth cone response to the axon guidance molecule, collapsin-1
49. Motor axon subpopulations are respond differentially to the chemorepellents netrin-1 and semaphorin D
50. A role for collapsin-1 in olfactory and cranial sensory axons
51. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice
52. Comparison of neurotrophin and repellent sensitivities of early embryonic geniculate and trigeminal axons
53. Semaphorin 3A is required for guidance of olfactory axons in mice
54. Semaphorins III and IV repel hippocampal axons via two distinct receptors
55. Patterning of cortical efferent projections by semaphorin-neuropilin interactions
56. Semaphorin 3A is a chemoattractant for cortical apical dendrites
57. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart
58. Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection
59. Many major CNS axon projections develop normally in the absence of semaphorin III
60. The development and subsequent elimination of aberrant peripheral axon projections in Semaphorin 3A null mutant mice
61. Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins
62. Neuropilin-2 is a receptor for semaphorin IV: Insight into the structural basis of receptor function and specificity
63. Sema 3C and netrin-1 differentially affect axon growth in the hippocampal formation
64. Chemoattraction and chemorepulsion of olfactory bulb axons by different secreted semaphorins
65. Mouse semaphorin H inhibits neurite outgrowth from sensory neurons
66. Squeezing axons out of the gray matter: A role for slit and semaphorin proteins from midline and ventral spinal cord
67. Transmembrane grasshopper semaphorin I promotes axon outgrowth in vivo
68. Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections
69. Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors
70. Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides
71. Slits proteins: Key regulators of axon guidance, axonal branching, and cell migration
72. Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse
73. Developmental localization of semaphorin H messenger RNA acting as a collapsing factor on sensory axons in the mouse brain
74. Semaphorin III can repulse and inhibit adult sensory afferents in vivo
75. 2+ influx
76. Semaphorin III can induce death in sensory neurons
77. Semaphorins as mediators of neuronal apoptosis
78. Ectopic semaphorin-1A functions as an attractive guidance cue for developing peripheral neurons
79. The transmembrane protein semaphorin 6A repels embryonic sympathetic axons
80. Cloning and characterization of a novel class VI semaphorin, semaphorin
81. Cloning and expression of semaphorin W, a new member of semaphorin family
82. Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors
83. Divergent properties of mouse netrins
84. Axon guidance: Netrin receptors are revealed
85. Deleted in colorectal cancer (DCC) encodes a Netrin receptor
86. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors
87. The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein
88. Expression of the netrin-1 receptor, deleted in colorectal cancer (DCC), is largely confined to projecting neurons in the developing forebrain
89. Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor
90. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts Netrin-induced growth cone attraction to repulsion
91. cAMP-induced switching in turning direction of nerve growth cones
92. cAMP-dependent growth cone guidance by netron-1
93. Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1
94. Attraction versus repulsion: Modular receptors make the difference in axon guidance
95. Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons
96. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
97. Guidance of circumferentially growing axons by netrin-dependent and -independent floor plate chemotropism in the vertebrate brain
98. A role for netrin-1 in the guidance of cortical efferents
99. Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection
100. Guidance of cerebellofugal axons in the rat embryo: Directed growth toward the floor plate and subsequent elongation along the longitudinal axis
101. Netrin-1 acts as an attractive and as a repulsive cue for distinct neuronal populations during the development of the cerebellar system
102. Extension of long leading processes and neuronal migration in the mammalian brain directed by the chemoattractant netrin-1
103. Netrin-1 and DCC mediate axon guidance locally at the optic disk: Loss of function leads to optic nerve hypoplasia
104. Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC
105. Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1-and DCC-deficient mice
106. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons
107. Axon guidance: Starting and stopping with slit
108. New roundabouts send axons into the Fas lane
109. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
110. Slit is the midline repellent for the robo receptor in Drosophila
111. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
112. Slit2-Mediated chemorepulsion and collapse of developing forebrain axons
113. Slit repulsion influences thalamocortical and retinal axon pathfinding in the diencephalon
114. Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons
115. Hepatocyte growth factor, a versatile signal for developing neurons
116. The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons
117. Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons
118. Cajal-Retzius cells, Reelin, and the formation of layers
119. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
120. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
121. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
122. The reeler mouse as a model of brain development
123. A role for Cajal-Retzius cells and reelin in the development of hippocampal connections
124. Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections
125. Development of commissural connections in the hippocampus of reeler mice: Evidence of an inhibitory influence of Cajal-Retzius cells
126. BMPs as mediators of roof plate repulsion of commissural neurons
127. Retinoic acid as a chemotactic molecule in neuronal development
128. Alteration of the retinotectal projection map by the graft of mesencephalic floor plate or Sonic hedgehog
129. Riding the glial monorail: A common mechanism for glial-guided neuronal migration in different regions of the developing mammalian brain
130. Migratory pathways and neuritic differentiation of inferior olivary neurons in the rat embryo: Axonal tracing study using the in vitro slab technique
131. Migration of immature neurons along tangentially oriented fibers in the subpial part of the fetal mouse medulla oblongata
132. Dynamics of cell migration from the lateral ganglionic eminence in the rat
133. Subventricular zone-olfactory bulb migratory pathway in the adult mouse: Cellular composition and specificity as determined by heterochronic and heterotopic transplantation
134. Chain migration of neuronal precursors
135. Interneuron migration from basal forebrain to neocortex: Dependence on DLX genes
136. Origin and route of tangentially migrating neurons in the developing neocortical intermediate zone
137. Direct evidence for homotypic, glia-independent neuronal migration
138. Functional properties of tangentially and radially migrating cortical neurons
139. Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex
140. Chemorepulsion of neuronal migration by Slit2 in the developing mammalian forebrain
141. Directional guidance of neuronal migration in the olfactory system by the protein Slit
142. A septum-derived chemorepulsive factor for migrating olfactory interneuron precursors
143. Evidence for collapsin-1 functioning in the control of neural crest migration in both trunk and hindbrain regions
144. Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons
145. The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina
146. Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration
147. Identification of semaphorin E gene expression in metastatic human lung adenocarcinoma cells by mRNA differential display
148. Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines
149. Potential mechanisms of mutations that affect neuronal migration in man and mouse
150. Reelin controls position of autonomic neurons in the spinal cord
151. Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalon
152. Cerebral cortical dysplasia associated with pediatric epilepsy. Review of neuropathologic features and proposal for a grading system
153. Molecular genetic classification of central nervous system malformations
154. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene
155. Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary
156. Role of L1 in neural development: What the knockouts tell us
157. Adhesion molecules and inherited diseases of the human nervous system
158. Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1
159. Disruption of the mouse L1 gene leads to malformations of the nervous system
160. L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns
161. Abnormalities in neuronal process extension, hippocampal development, and the ventricular system of L1 knockout mice
162. L1-associated diseases: Clinical geneticist divide, molecular biologists unite
163. Neural cell recognition molecule L1: From cell biology to human hereditary brain malformations
164. Two missense mutations in human L1 associated with CRASH syndrome reduce L1 interaction with ankyrin
165. The L1 family of neural cell adhesion molecules: Old molecules performing new tricks
166. Optic nerve hypoplasia in children. Association with anomalies of the endocrine and CNS
167. Netrin 1 is required for semicircular canal formation in the mouse inner ear
168. Reelin gene alleles and halotypes are associated with autistic disorder
169. Preselenin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
170. Genetics of neuronal migration in the cerebral cortex
171. Parallel regulation of Sema 3C and Sema 3C receptor expression in CA1 pyramidal cell layer of rat hippocampus after kainic acid induced status epilepticus
172. Inhibitors of neurite growth
173. Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS
174. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
175. Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment
176. Role for semaphorin III and its receptor neuropilin-1 in neuronal regeneration and scar formation?
177. Retinal axon guidance by region-specific cues in diencephalon
178. Guidance of regenerating motor axons in vivo by gradients of diffusible peripheral nerve-derived factors
179. Netrin-1 and peripheral nerve regeneration in the adult rat
180. Genetic analysis of the mechanisms controlling target selection: Complementary and combinatorial functions of Netrins, semaphorins, and IgCAMs
181. Chimeric axon guidance receptors: The cytoplasmic domains of slits and netrin receptors specify attraction versus repulsion
182. Stimulus strory alters behavioural responses of neuronal growth cones
183. Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain