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Chemotropic guidance of developing axons in the mammalian central nervous system
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The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
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Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M: The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 1994, 78:409-424.
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Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
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The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells of the epidermis in C. elegans
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UNC-6, a laminin-related protein,guides cell and pioneer axon migrations in C. elegans
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Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
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The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons
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Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
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Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
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Guidance cues at the Drosophila CNS midline: Identification and characterization of two Drosophila netrin/UNC-6 homologs
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UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans
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Leung-Hagesteijn C, Spence AM, Stern BD, Zhou Y, Su M-W, Hedgecock EM, Culotti JG: UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell 1992, 71:289-299.
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UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer) is required in motile cells responding to UNC-6 netrin cues
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Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule Deleted in Colorectal Cancer
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Deleted in Colorectal Cancer encodes a netrin receptor
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Frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance
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Kolodziej PA, Timpe LC, Mitchell KJ, Fried SR, Goodman CS, Jan LY, Jan YN: frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 1996, 87:197-204.
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Jan, Y.N.7
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Guidance of circumferentially-growing axons by netrin-dependent and independent floor plate chemotropism in the vertebrate brain
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Shirasaki R, Mirzayan C, Tessier-Lavigne M, Murakami F: Guidance of circumferentially-growing axons by netrin-dependent and independent floor plate chemotropism in the vertebrate brain. Neuron 1997, in press.
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