Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary

Development

Volumn 125, Issue 1, 1998, Pages 41-50

  Przyborski, Stefan A ^a   Knowles, Barbara B ^a   Ackerman, Susan L ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

Cerebellum; Granule cell; Migration; Mouse; Netrin1; Purkinje cell; Unc5h3

Indexed keywords

CHEMOREPELLENT; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN STEM; CELL MIGRATION; CELL PROLIFERATION; CEREBELLUM; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO DEVELOPMENT; GENE; GENE EXPRESSION; GRANULE CELL; INFERIOR COLLICULUS; MOUSE; MOUSE MUTANT; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PURKINJE CELL; RHOMBENCEPHALON; STEM CELL;

ANIMALS; BRAIN STEM; CELL MOVEMENT; CEREBELLUM; EMBRYONIC AND FETAL DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MESENCEPHALON; MICE; MICE, TRANSGENIC; MUTATION; NERVE GROWTH FACTORS; NEURONS; PHENOTYPE; PURKINJE CELLS; RECEPTORS, NERVE GROWTH FACTOR; SIGNAL TRANSDUCTION; STEM CELLS; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MAMMALIA;

EID: 0031964951     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Ackerman, S. L., Kozak, L. P., Przyborski, S. A., Rund, L. A., Boyer, B. B. and Knowles, B. B. (1997). The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature 386, 838-842.
2. Alder, J., Cho, N. K. and Hatten, M. E. (1996). Embryonic precursor cells from the rhombic lip are specified to a cerebellar granule neuron identity. Neuron 17, 389-399.
3. Altman, J. and Bayer, S. A. (1997). Development of the Cerebellar System in Relation to its Evolution, Structure and Functions. Boca Raton: CRC Press Inc.
4. Akazawa, C., Ishibashi, M., Shimizu, C., Nakanishi, S. and Kageyama, R. (1995). A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J. Biol. Chem. 270, 8730-8738.
5. Ben-Arie, N., McCall, A. E., Berkman, S., Eichele, G., Bellen, H. J. and Zoghbi, H. Y. (1996). Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Hum. Mol. Gen. 5, 1207-1216.
6. Boyer, B. B. and Kozak, L. P. (1991). The mitochondrial uncoupling protein gene in brown fat: correlation between DNase I hypersensitivity and expression in transgenic mice. Mol Cell. Biol. 11, 4147-4156.
7. Chan, S. S.-Y, Zheng, H., Su, M.-W., Wilk, Killeen, M. T., Hedgecock, E. M. and Culotti, J. G. (1996). UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87, 187-195.
8. Colamarino S. A. and Tessier-Lavigne M. (1995). The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81, 621-629.
9. Fazeli, A. et al., (1997). Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene. Nature 386, 796-804.
10. Haddara, M. A. and Nooreddin, M. A. (1966). A quantitative study on the postnatal development of the cerebellar vermis of the mouse. J. Comp. Neurol. 128, 245-254.
11. Hamelin, M., Zhou, Y., Su, M.-W., Scott I. M. and Culotti, J. G. (1993). Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature 364, 327-330.
12. Hamilton, B. A. et al., (1996). Disruption of the nuclear hormone receptor RORa in staggerer mice. Nature 379, 736-739.
13. Hamre, K. M. and Goldowitz, D. (1996). Analysis of gene action in the Meander Tail mutant mouse: Examination of cerebellar phenotype and mitotic activity of granule cell neuroblasts. J. Comp. Neurol. 368, 304-315.
14. Harris, R., Sabatelli, L. M. and Seeger, M. A. (1996). Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs. Neuron 17, 217-228.
15. Hatten, M. E. and Heintz, N. (1995). Mechanisms of neural patterning and specification in the developing cerebellum. Annu. Rev. Neurosci. 18, 385-408
16. Hedgecock, E. M., Culotti, J. G. and Hall, D. H. (1990). The unc-5, unc-6 and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 2, 61-85.
17. J mutation contains an intragenic deletion of the Gli3 gene. Nature Genet. 3, 241-246.
18. Inouye, M. and Murakami, U. (1980). Temporal and spatial patterns of Purkinje cell formation in the mouse cerebellum. J. Comp. Neurol. 194, 499-503.
19. Ishii, N., Wadsworth, W. G., Stern, B. D., Culotti, J. G. and Hedgecock, E. M. (1992). UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9, 873-881.
20. Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E. D., Chan, S. S.-Y, Culotti, J. G. and Tessier-Lavigne, M. (1996). Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell 87, 175-185.
21. Kennedy, T. E., Serafini, T., de la Torre, J. R. and Tessier-Lavigne, M. (1994). Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78, 425-435.
22. Lane, P. W., Bronson, R. T. and Spencer, C. A. (1992). Rostral Cerebellar Malformation (rcm): A new recessive mutation on chromosome 3 of the mouse. J. Hered. 83, 315-318.
23. Le Douarin, N. M. and Ziller, C. (1993). Plasticity in neural crest cell differentiation. Curr. Opin. Cell Biol. 5, 1036-43.
24. Leonardo, E. D., Hinck, L., Masu, M., Keino-Masu, K., Ackerman, S. L. and Tessier-Lavigne, M. (1997). Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386, 833-838.
25. Leung-Hagesteijn, C., Spence, A. M., Stern, B. D., Zhou, Y., Su, M.-W., Hedgecock, E. M. and Culotti, J. G. (1992). UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell 71, 289-299.
26. Mares, V. and Lodin, Z. (1970). The cellular kinetics of the developing mouse cerebellum. II. The function of the external granular layer in the process of gyrification. Brain Res. 23, 343-352.
27. Mitchell, K. J. et al. (1996). Genetic analysis of Netrin genes in Drosophila: netrins guide CNS commissural axons and peripheral motor axons. Neuron 17, 203-215.
28. Placzek, M., Tessier-Lavigne, M., Jessel, T. and Dodd, J. (1990). Orientation of commissural axons in vitro in response to a floor plate-derived chemoattractant. Development 110, 19-30
29. Rugh, R. (1990). The Mouse: its Reproduction and Development. Oxford: Oxford University Press.
30. Serafini, T., Colamarino, S. A., Leonardo, E. D., Wang, H., Beddington, R., Skarnes, W. C. and Tessier-Lavigne, M. (1996). Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87, 1001-1014.
31. Serafini, T., Kennedy, T. E., Galko, M. J., Mirzayan, C., Jessell, T. M. and Tessier-Lavigne, M. (1994). The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424.
32. Shirasaki, R., Mirzayan, C., Tessier-Lavigne, M. and Murakami, F. (1996). Guidance of circumferentially growing axons by netrin-dependent and -independent floor plate chemotropism in the vertebrate brain. Neuron 17, 1079-1088.
33. Shirasaki, R., Tamada, A., Katsumata, R. and Murakami, F. (1995). Guidance of cerebellofugal axons in the rat embryo: Directed growth toward the floor plate and subsequent elongation along the longitudinal axis. Neuron 14, 961-972.
34. Tessier-Lavigne, M., Placzek, M., Lumsden, A., Dodd, J. and Jessell, T. M. (1988). Chemotropic guidance of developing axons in the mammalian central nervous system. Nature 336, 775-778.
35. Tessier-Lavigne, M. and Goodman, C.S. (1996). The molelcular biology of axon guidance. Science 274, 1123-1133.
36. Wadsworth, W. G., Bhatt, H. and Hedgecock, E. M. (1996). Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron 16, 35-46.
37. Yang, X. W., Zhong, R. and Heintz, N. (1996). Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49. Development 122, 555-566.