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of outstanding interest. This paper is the first to demonstrate that Reelin is a secreted glycoprotein. The authors show that a highly charged carboxy-terminal region is essential for secretion. The data presented in this paper suggest that Reelin is secreted by Cajal - Retzius cells and that it is a component of the extracellular matrix in the marginal zone, where Cajal - Retzius cells are located. Moreover, this paper proves that the CR-50 monoclonal antibody recognizes Reelin, in particular an epitope near the amino terminus.
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of outstanding interest D'Arcangelo G, Nakajima K, Miyata T, Ogawa M, Mikoshiba K, Curran T. Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J Neurosci. 17:1997;23-31 This paper is the first to demonstrate that Reelin is a secreted glycoprotein. The authors show that a highly charged carboxy-terminal region is essential for secretion. The data presented in this paper suggest that Reelin is secreted by Cajal - Retzius cells and that it is a component of the extracellular matrix in the marginal zone, where Cajal - Retzius cells are located. Moreover, this paper proves that the CR-50 monoclonal antibody recognizes Reelin, in particular an epitope near the amino terminus.
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D'Arcangelo, G.1
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of outstanding interest. This paper not only summarizes the author's comprehensive studies on the ontogenetic and phylogenetic development of the cortex, including his studies on Cajal - Retzius cells, but also proposes a new neomenclature of cortical layers. He suggests that the layers of the neocortex derived from the cortical plate and sandwiched between the marginal zone and subplate be numbered in an inside-out sequence according to their appearance during phylogenetic (and ontogenetic) development, rather than the outside in system used currently.
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of outstanding interest Marin-Padilla M. Cajal - Retzius cells and the development of the neocortex. Trends Neurosci. 21:1998;64-71 This paper not only summarizes the author's comprehensive studies on the ontogenetic and phylogenetic development of the cortex, including his studies on Cajal - Retzius cells, but also proposes a new neomenclature of cortical layers. He suggests that the layers of the neocortex derived from the cortical plate and sandwiched between the marginal zone and subplate be numbered in an inside-out sequence according to their appearance during phylogenetic (and ontogenetic) development, rather than the outside in system used currently.
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of special interest. Previous studies showed that the ablation of meningeal cells by 6-hydroxy-dopamine (6-OHDA) results in characteristic migration defects. The authors of this paper suggest that the effect of meningeal cell destruction on migration may be an indirect one, because ablation of meningeal cells by the treatment with 6-OHDA results in the rapid degeneration of Cajal - Retzius cells. The authors suggest a trophic dependence of Cajal - Retzius cells upon meningeal cells.
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of special interest Supér H, Martinez A, Soriano E. Degeneration of Cajal - Retzius cells in the developing cerebral cortex of the mouse after ablation of meningeal cells by 6-hydroxydopamine. Dev Brain Res. 98:1997;15-20 Previous studies showed that the ablation of meningeal cells by 6-hydroxy-dopamine (6-OHDA) results in characteristic migration defects. The authors of this paper suggest that the effect of meningeal cell destruction on migration may be an indirect one, because ablation of meningeal cells by the treatment with 6-OHDA results in the rapid degeneration of Cajal - Retzius cells. The authors suggest a trophic dependence of Cajal - Retzius cells upon meningeal cells.
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of outstanding interest. In co-cultures of entorhinal cortex and hippocampus from neonatal animals, synapses were found between biocytin-labeled entorhinal axons and calretinin-immunostained Cajal - Retzius cells. Selective elimination of Cajal - Retzius cells by excitotoxic lesions prevented the ingrowth of entorhinal fibers into their target layers in these co-cultures. Reelin does not appear to be involved in pathfinding, as entorhinal axons found their target layers in co-cultures blocked with the CR-50 antibody against an epitope of Reelin. Similarly, anterograde fiber tracing in reeler mice revealed an essentially normal entorhino-hippocampal projection. However, Reelin was found to affect the branching pattern of entorhinal axons.
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of outstanding interest Del Rio JA, Heimrich B, Borrell V, Förster E, Drakew A, Alcántara S, Nakajima K, Miyata T, Ogawa M, Mikoshiba K, et al. A role for Cajal - Retzius cells and reelin in the development of hippocampal connections. Nature. 385:1997;70-74 In co-cultures of entorhinal cortex and hippocampus from neonatal animals, synapses were found between biocytin-labeled entorhinal axons and calretinin-immunostained Cajal - Retzius cells. Selective elimination of Cajal - Retzius cells by excitotoxic lesions prevented the ingrowth of entorhinal fibers into their target layers in these co-cultures. Reelin does not appear to be involved in pathfinding, as entorhinal axons found their target layers in co-cultures blocked with the CR-50 antibody against an epitope of Reelin. Similarly, anterograde fiber tracing in reeler mice revealed an essentially normal entorhino-hippocampal projection. However, Reelin was found to affect the branching pattern of entorhinal axons.
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Nature
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Del Rio, J.A.1
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of outstanding interest. Intraventricular injection of CR-50 antibody against Reelin during embryonic development in mice results in a reeler-like malformation of the pyramidal layer in hippocampal region CA1. This indicates that Reelin is involved in the formation of the pyramidal layer and that the CR-50 antibody recognizes and blocks a functionally important epitope of Reelin.
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of outstanding interest Nakajima K, Mikoshiba K, Miyata T, Kudo C, Ogawa M. Disruption of hippocampal development in vivo by CR-50 mAb against Reelin. Proc Natl Acad Sci USA. 94:1997;8196-8201 Intraventricular injection of CR-50 antibody against Reelin during embryonic development in mice results in a reeler-like malformation of the pyramidal layer in hippocampal region CA1. This indicates that Reelin is involved in the formation of the pyramidal layer and that the CR-50 antibody recognizes and blocks a functionally important epitope of Reelin.
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Proc Natl Acad Sci USA
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Deller T, Martinez A, Nitsch R, Frotscher M. A novel entorhinal projection to the rat dentate gyrus: direct innervation of proximal dendrites and cell bodies of granule cells and GABAergic neurons. J Neurosci. 16:1996;3322-3333.
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Deller, T.1
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Frotscher, M.4
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0345627992
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Involvement of distinct pioneer neurons in the formation of layer-specific connections in the hippocampus
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of outstanding interest. This paper shows that different types of primary target neurons are involved in the formation of layer-specific connections in the hippocampus. The paper confirms an important role for Cajal - Retzius cells in the layer-specific termination of entorhinal afferents. In addition, GABAergic cells in the termination zones of commissural afferents to the hippocampus were identified as primary targets for commissural fibers.
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of outstanding interest Supér H, Martinez A, Del Rio JA, Soriano E. Involvement of distinct pioneer neurons in the formation of layer-specific connections in the hippocampus. J Neurosci. 18:1998;4616-4626 This paper shows that different types of primary target neurons are involved in the formation of layer-specific connections in the hippocampus. The paper confirms an important role for Cajal - Retzius cells in the layer-specific termination of entorhinal afferents. In addition, GABAergic cells in the termination zones of commissural afferents to the hippocampus were identified as primary targets for commissural fibers.
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J Neurosci
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Supér, H.1
Martinez, A.2
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of special interest. This study suggests that scrambler, whose phenotype includes perturbed cortical migration and abnormal outside-in formation of layers, results from a mutation downstream of the reelin gene as Reelin immunoreactivity is present in the scrambler cortex in a normal pattern.
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of special interest González JL, Russo CJ, Goldowitz D, Sweet HO, Davisson MT, Walsh CA. Birthdate and cell marker analysis of scrambler: a novel mutation affecting cortical development with a reeler-like phenotype. J Neurosci. 17:1997;9204-9211 This study suggests that scrambler, whose phenotype includes perturbed cortical migration and abnormal outside-in formation of layers, results from a mutation downstream of the reelin gene as Reelin immunoreactivity is present in the scrambler cortex in a normal pattern.
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Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration
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Sweet HO, Bronson RT, Johnson KR, Cook SA, Davisson MT. Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mammalian Genome. 7:1996;798-802.
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Sweet, H.O.1
Bronson, R.T.2
Johnson, K.R.3
Cook, S.A.4
Davisson, M.T.5
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43
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0030704354
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Neuronal position in the developing brain is regulated by mouse disabled-1
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of outstanding interest. This and the paper by Sheldon et al. [44] show that mutations in mdab-1, a mouse gene related to the Drosophila gene disabled (dab), result in a reeler- like phenotype. mDab-1 appears to function as an intracellular adaptor protein.
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of outstanding interest Howell BW, Hawkes R, Soriano P, Cooper JA. Neuronal position in the developing brain is regulated by mouse disabled-1. Nature. 388:1997;733-737 This and the paper by Sheldon et al. [44] show that mutations in mdab-1, a mouse gene related to the Drosophila gene disabled (dab), result in a reeler- like phenotype. mDab-1 appears to function as an intracellular adaptor protein.
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(1997)
Nature
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Howell, B.W.1
Hawkes, R.2
Soriano, P.3
Cooper, J.A.4
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44
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0030717493
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Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice
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of outstanding interest. The authors report that the autosomal-recessive mouse mutations, scrambler and yotari, arise from mutations in mdab-1 (see [43]).
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of outstanding interest Sheldon M, Rice DS, D'Arcangelo G, Yoneshima H, Nakajima K, Mikoshiba K, Howel BW, Cooper JA, Goldowitz D, Currant T. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature. 389:1997;730-733 The authors report that the autosomal-recessive mouse mutations, scrambler and yotari, arise from mutations in mdab-1 (see [43]).
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(1997)
Nature
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, pp. 730-733
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Sheldon, M.1
Rice, D.S.2
D'Arcangelo, G.3
Yoneshima, H.4
Nakajima, K.5
Mikoshiba, K.6
Howel, B.W.7
Cooper, J.A.8
Goldowitz, D.9
Currant, T.10
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45
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0029881805
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Distribution of mesencephalic trigeminal nucleus neurons in the reeler mutant mouse
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Terashima T. Distribution of mesencephalic trigeminal nucleus neurons in the reeler mutant mouse. Anal Rec. 244:1996;563-571.
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Terashima, T.1
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46
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0030908070
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Regulation of Purkinje cell alignment by Reelin as revealed with CR-50 antibody
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Miyata T, Nakajima K, Mikoshiba K, Ogawa M. Regulation of Purkinje cell alignment by Reelin as revealed with CR-50 antibody. J Neurosci. 17:1997;3599-3609.
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Miyata, T.1
Nakajima, K.2
Mikoshiba, K.3
Ogawa, M.4
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48
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0030902291
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Cajal - Retzius cells regulate the radial glia phenotype in the adult and developing cerebellum and alter granule cell migration
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of special interest. This study shows that transplantation of embryonic Cajal - Retzius cells into the adult cerebellum induces a rejuvenation of host Bergmann glial cells into a radial glia phenotype. Evidence is provided that these effects are mediated by diffusible molecules.
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of special interest Soriano E, Alvarado-Mallart RM, Dumesnil N, Del Rio JA, Sotelo C. Cajal - Retzius cells regulate the radial glia phenotype in the adult and developing cerebellum and alter granule cell migration. Neuron. 18:1997;563-577 This study shows that transplantation of embryonic Cajal - Retzius cells into the adult cerebellum induces a rejuvenation of host Bergmann glial cells into a radial glia phenotype. Evidence is provided that these effects are mediated by diffusible molecules.
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(1997)
Neuron
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Soriano, E.1
Alvarado-Mallart, R.M.2
Dumesnil, N.3
Del Rio, J.A.4
Sotelo, C.5
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49
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0030848528
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Expression of reelin, the gene responsible for the reeler mutation, in embryonic development and adulthood in the mouse
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of special interest. The authors analyzed reelin expression in various organs during development and adulthood. In adult animals, reelin is expressed in brain, spinal cord, liver, kidney, testis, and ovary, suggesting yet unknown functions of reelin in the mature organism.
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of special interest Ikeda Y, Terashima T. Expression of reelin, the gene responsible for the reeler mutation, in embryonic development and adulthood in the mouse. Dev Dyn. 210:1997;157-172 The authors analyzed reelin expression in various organs during development and adulthood. In adult animals, reelin is expressed in brain, spinal cord, liver, kidney, testis, and ovary, suggesting yet unknown functions of reelin in the mature organism.
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(1997)
Dev Dyn
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, pp. 157-172
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Ikeda, Y.1
Terashima, T.2
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