Selectivity and activity of adenine dinucleotides at recombinant P2x2 and P2Y1 purinoceptors

British Journal of Pharmacology

Volumn 119, Issue 5, 1996, Pages 1006-1012

  Pintor, Jesus ^a,b   King, B F ^a   Miras Portugal, M T ^a,b   Burnstock, G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Adenine dinucleotide; ATP; Diadenosine polyphosphate; P2 purinoceptors; Purine; Recombinant receptor; Xenopus oocytes

Indexed keywords

ADENINE; ADENOSINE TRIPHOSPHATE; DINUCLEOTIDE; PURINE P2X RECEPTOR; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; RECOMBINANT PROTEIN; SURAMIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; XENOPUS;

EID: 0029966778     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15771.x     Document Type: Article

References (53)

1. ABBRACCHIO, M.P. & BURNSTOCK, G. (1995). Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol. Ther., 64, 445-475.
2. 2 purinoceptor from human erythroleukaemic cells. J. Biol. Chem., 271, 18363-18367.
3. BARISH, M.E. (1983). A transient calcium-dependent chloride current in immature Xenopus oocyte. J. Physiol., 342, 309-325.
4. BO, X., ZHANG, Y., NASSAR, M., BURNSTOCK, G. & SCHÖEPFER, R. (1995). A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Lett., 375, 129-133.
5. BRAKE, A.J., WAGENBACH, M.J. & JULIUS, D. (1994). New Structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature, 371, 519-523.
6. CASTRO, E., TORRES, M., MIRAS-PORTUGAL, M.T. & GONZALEZ, M.P (1990). Effect of diadenosine polyphosphates on catecholamine secretion from isolated chromaffin cells. Br. J. Pharmacol., 100, 360-364.
7. 2 nucleotide receptor. J. Biol. Chem., 271, 26152-26158.
8. CHEN, C., AKOPIAN, A.N., SIVILOTTI, L., COLQUHOUN, D., BURNSTOCK, G. & WOOD, J.N. (1995). A P2X purinoceptor expressed by a subset of sensory neurons. Nature, 377, 428-431.
9. 6 receptors, and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci., 16, 2495-2507.
10. COMMUNI, D., PIROTTON, S., PARMENTIER, M. & BOEYNAEMS, J.-M. (1995). Cloning and functional expression of a human uridine nucleotide receptor. J. Biol. Chem., 270, 30849-30852.
11. 3-triphosphate in yeast at heat shock. FEBS Lett., 178, 149-152.
12. FEDAN, J.S. & GRANT, L.J.R. (1995). Potentiating and inhibitory effects of periodate-oxydized ATP analogs on contractions of vas deferens to ATP. Eur. J. Pharmacol., 281, 213-217.
13. FEDAN, J.S. & LAMPORT, S.J. (1990). Two dissociable phases in the contractile response of the guinea-pig vas deferens to adenosine triphosphate. J. Pharmacol. Exp. Ther., 253, 993-998.
14. 4-tetraphosphate in single rat hepatocytes are indistinguishable from those induced by ADP and ATP respectively. Biochem. J., 310, 629-635.
15. 4-tetraphosphate triggers initiation of in vitro DNA replication in baby hamster kidney cells. Proc. Natl. Acad. Sci. U.S.A., 75, 371-377.
16. HOYLE, C.H.V. (1990). Pharmacological activity of adenine dinucleotides in the periphery: possible receptor classes and transmitter function. Gen. Pharmacol., 21, 827-831.
17. HOYLE, C.H.V. & BURNSTOCK, G. (1992). Actions of purine nucleotides on isolated circular muscle from the human sigmoid colon: evidence for a novel class of purinoceptor. Int. J. Purine Pyrimidine Res., 3, 13.
18. + current in follicular oocytes of Xenopus laevis. J. Pharmacol. Exp. Ther., 276, 93-100.
19. 2 purinoceptor subtypes activate inward current in folliculated oocytes of Xenopus laevis. Br. J. Pharmacol., 116, 50P.
20. 2 purinoceptor-activated inward currents in follicular oocytes of Xenopus laevis. J. Physiol., 494, 17-28.
21. 2 purinoceptor revealed by changing extracellular pH. Br. J. Pharmacol., 117, 1371-1373.
22. KLISHIN, A., LOZOVAYA, N., PINTOR, J., MIRAS-PORTUGAL, M.T. & KRISHTAL, O.A. (1994). Possible functional role of diadenosine polyphosphates: negative feedback for excitation in hippocampus. Neuroscience, 58, 235-236.
23. KRISHTAL, O.A., MARCHENKO, S.M., OBUKHOV, A.G. & VOLKOVA, T.M.(1988). Receptors for ATP in rat sensory neurones: the structure-function relationship for ligands. Br. J. Pharmacol., 95, 1057-1067.
24. LANDAU, E.M. & BLITZER, R.D. (1994). Chloride current assay for phospholipase C in Xenopus oocytes. Methods Enzymol., 238, 140-154.
25. 2U purinoceptor: potent activation by diadenosine tetraphosphate. Br. J. Pharmacol., 116, 1619-1627.
26. 3 receptor subunits can account for ATP-gated currents in sensory nuerons. Nature, 377, 432-435.
27. LUSTIG, K.D., SHIAU, A.K., BRAKE, A.J. & JULIUS, D. (1993). Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc. Natl. Acad. Sci. U.S.A., 90, 5113-5117.
28. 3A) mediates human platelet aggregation by liberation of ADP. Biochem. Biophys. Res. Commun., 115, 253-260.
29. 5A and α,β-methylene ATP on non-adrenergic, non-cholinergic neurogenic excitation in the guinea pig vas deferens. Br. J. Pharmacol., 94, 699-706.
30. MARCHENKO, S.M., OBUKHOV, A.G., VOLKOVA, T.M. & TARUSOVA, N.B. (1988). Bis (5′adenosyl) tetraphosphate a partial agonist of the ATP receptors on sensory neurons of the rat. Neurofiziologia, 20, 427-431.
31. 4A and other Dinucleoside Polyphosphates. McLennan, A.G. pp. 1-7. Florida: CRC Press.
32. 2 purinoceptors present on rat brain synaptic terminals. Br. J. Pharmacol., 108, 1094-1099.
33. 2+ dependent release evoked by 4-aminopyridine and veratridine. Neurosci. Lett., 136, 141-144.
34. PINTOR, J., KOWALEWSKI, H.J., TORRES, M., MIRAS-PORTUGAL, M.T. & ZIMMERMANN, H. (1992b). Synaptic vesicle storage of diadenosine polyphosphates in the Torpedo electric organ. Neurosci. Res. Commun., 10, 9-14.
35. PINTOR, J. & MIRAS-PORTUGAL, M.T. (1993). Diadenosine polyphosphates -ApnA- as new neurotransmitters. Drug. Devel. Res., 28, 259-262.
36. 2+ increase in rat brain synaptosomes. Br. J. Pharmacol., 115, 895-902.
37. 2 purinoceptors for diadenosine polyphosphates in the nervous system. Gen. Pharmacol., 26, 229-235.
38. PINTOR, J., ROTLLÁN, P., TORRES, M. & MIRAS-PORTUGAL, M.T. (1992c). Characterization and quantification of diadenosine hexaphosphate in chromaffin cells: granular storage and secretagogue-induced release. Anal. Biochem., 200, 296-300.
39. 2Y site. Br. J. Pharmacol., 103, 1980-1984.
40. RALEVIC, V., HOYLE, C.H.V. & BURNSTOCK, G. (1995). Pivotal role of phosphate chain length in vasoconstrictor versus vasodilator actions of adenine dinucleotides in rat mesenteric arteries. J. Physiol., 483, 703-713.
41. 5A- in bovine adrenal medulla: presence in chromaffin granules. J. Neurochem., 51, 1696-1703.
42. SCHLÜTER, H., OFFERS, E., BRUGGEMANN, G., VAN DER GLET, M., TEPEL, M., NORDHOFF, E., KARAS, M., SPIEKER, C., WITZEL, H. & ZIDEK, W. (1994). Diadenosine polyphosphate and the physiological control of blood pressure. Nature, 367, 186-188.
43. SCHUBERT, P., PINTOR, J. & MIRAS-PORTUGAL, M.T. (1995). Inhibitor actions of adenosine and adenine dinucleotides in the central nervous system. In Adenosine and Adenine Nucleotides: from Molecular Biology to Integrative Physiology. ed. Belardinelli, L. & Pelleg, A. pp. 181-288. Boston, Mass.: Kluwer Academic Publishers.
44. SIMON, J., WEBB, T.E., KING, B.F., BURNSTOCK, G. & BARNARD, E.A. (1995). Characterisation of a recombinant P2Y purinoceptor. Eur. J. Pharmacol. (Mol. Pharmacol. Sect.), 291, 281-289.
45. STONE, T.W. & PERKINS, M.N. (1981). Adenine dinucleotide effect on rat cortical neurones. Brain Res., 229, 241-245.
46. 2X7). Science, 272, 735-738.
47. TEPEL, M., BACHMANN, J., SCHLÜTER, H. & ZIDEK, W. (1996). Diadenosine polyphosphates increase cytosolic calcium and attenuate angiotensin-II-induced changes in calcium in vascular smooth muscle. J. Vasc. Res., 33, 132-138.
48. VALERA, S., HUSSY, N., EVANS, R.J., ADAMI, N., NORTH, R.A., SURPRENANT, A. & BUELL, G. (1994). A new class of ligandgated ion channel defined by P2X receptor for extracellular ATP. Nature, 371, 516-519.
49. 3) activated preferentially by nucleoside diphosphates. Mol. Pharmacol., (in press).
50. 5. Biochem. Biophys. Res. Commun., 219, 105-110.
51. WEBB, T.E., SIMON, J., KRISHEK, B.J., BATESON, A.N., SMART, T.G., KING, B.F., BURNSTOCK, G. & BARNARD, E.A. (1993). Cloning and functional expression of a brain G-protein coupled ATP receptor. FEBS Lett., 324, 219-225.
52. WILLIAMS, M. (1994). Purinoceptors nomenclature: challenges for the future. In Adenosine and Adenine Nucleotides: from Molecular Biology to Integrative Physiology. ed. Belardinelli, L. & Pelleg, A. pp. 39-48. Boston, Mass.: Kluwer Academic Publishers.
53. ZIGANSHIN, A.U., ZIGANSHINA, L.E., KING, B.F. & BURNSTOCK, G. (1995). Characteristics of ecto-ATPase of Xenopus oocytes and the inhibitory actions of suramin on ATP breakdown. Pflügers Arch., 429, 412-418.