Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C

British Journal of Pharmacology

Volumn 122, Issue 6, 1997, Pages 1021-1024

  Schachter, Joel B ^a   Boyer, José L ^a   Li, Qing ^a   Nicholas, Robert A ^a   Harden, T Kendall ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclic AMP; Inositol lipid signalling; P2Y1 receptor; Purine nucleotide; Signalling

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; PHOSPHOLIPASE C; PURINE P2Y RECEPTOR;

ANIMAL CELL; ARTICLE; ASTROCYTOMA CELL; GLIOMA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ANIMALS; CYCLIC AMP; ENZYME ACTIVATION; FORSKOLIN; HUMANS; PHOSPHOLIPASE C; PYRIDOXAL PHOSPHATE; RATS; RECEPTORS, PURINERGIC P2; THIONUCLEOTIDES; TUMOR CELLS, CULTURED; TURKEYS;

EID: 0030784636     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701479     Document Type: Article

References (23)

1. BERRIDGE, M.J., DAWSON, R.M.C., DOWNES, C.P., HESLOP, J.P. & IRVINE, R.F. (1983). Changes in the level of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem. J., 212, 473-482.
2. 2Y-purinergic receptor that inhibits adenylyl cyclase but does not activate phospholipase. C. J. Pharmacol. Exp. Ther., 267, 1140-1146.
3. 2Y-purinergic receptors. Br. J. Pharmacol., 113, 614-620.
4. BOYER, J.L., O'TUEL, J.W., FISCHER, B., JACOBSON, K.A. & HARDEN, T.K. (1995). Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2Y-purinoceptors. Br. J. Pharmacol., 116, 2611-2616.
5. 1-purinergic receptor. Mol. Pharmacol., 50, 1323-1329.
6. 2 nucleotide receptor. J. Biol. Chem., 270, 26152-26158.
7. COMMUNI, D., PIROTTON, S., PARMENTIER, M. & BOEYNAEMS, J.M. (1995). Cloning and functional expression of a human uridine nucleotide receptor. J. Biol. Chem., 270, 30849-30852.
8. 6 receptor. Biochem. Biophys. Res. Commun., 222, 303-308.
9. COMSTOCK, K.E., WATSON, N.F. & OLSEN, J.C. (1997), Design of retroviral expression vectors. Methods Mol. Biol., 62, 207-222.
10. 2-purinergic receptors for extracellular ATP and other nucleotides. Am. J. Physiol., 265, C557-C606.
11. 2Y purinoceptors in rat brain microvascular endothelial cells. Br. J. Pharmacol., 115, 1199-1203.
12. 2Y-purinergic receptor that couples to phospholipase C. Mol. Pharmacol., 46, 8-14.
13. FREDHOLM, B.B., ABBRACHIO, M.P., BURNSTOCK, G., DUBYAK, G.R., HARDEN, T.K., JACOBSON, K.A., SCHWABE, U. & WILLIAMS, M. (1997). Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol. Sci., 18, 79-82.
14. HOURANI, S.M.O. & HALL, D.A. (1994). Receptors for ADP on human blood platelets. Trends Pharmacol. Sci., 15, 103-108.
15. 1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. FEBS Lett., 403, 26-30.
16. NGUYEN, T., ERB, L., WEISMANN, G.A., MARCHESE, A., HENG, H.H.Q., GARRAD, R.C., GEORGE, S.R., TURNER, J.T. & O'DOWD, B.F. (1995). Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. J. Biol. Chem., 270, 30845-30848.
17. 2U nucleotide receptor, a target for cystic fibrosis pharmacology. Proc. Natl. Acad. Sci. U.S.A., 91, 3275-3279.
18. PIANET, I., MERLE, M. & LABOUESSE, J. (1989). ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells. Biochem. Biophys. Res. Commun., 163, 1150-1157.
19. SALOMON, Y., LONDOS, C. & RODBELL, M. (1974). A highly sensitive adenylate cyclase assay. Anal. Biochem., 58, 541-548.
20. 2Y1 receptor. Br. J. Pharmacol., 118, 167-173.
21. 1 receptor. Br. J. Pharmacol., 121, 338-344.
22. VIGNE, P., FEOLDE, E., BREITTMAYER, J.P. & FRELIN, C. (1994). Characterization of the effects of 2-methylthio-ATP and 2-chloro-ATP on brain capillary endothelial cells. Similarities to ADP and differences from ATP. Br. J. Pharmacol., 112, 775-780.
23. WEBB, T.E., FEOLDE, E., NEARY, J.T., RUNBERG, A., FRELIN, C. & BARNARD, E.A (1996). The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase. Br. J. Pharmacol., 119, 1385-1392.