Pharmacological and second messenger signalling selectivities of cloned P2Y receptors

Journal of Autonomic Pharmacology

Volumn 16, Issue 6, 1996, Pages 319-324

  Nicholas, R A ^a   Lazarowski, E R ^a   Watt, W C ^a   Li, Q ^a   Boyer, J ^a   Harden, T K ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLTHIOADENOSINE DIPHOSPHATE; 2 METHYLTHIOADENOSINE TRIPHOSPHATE; ADENINE NUCLEOTIDE; ADENOSINE 5' O (2 THIODIPHOSPHATE); ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; INOSITOL PHOSPHATE; NUCLEOTIDE DERIVATIVE; PHOSPHOLIPASE C; PURINE P2Y RECEPTOR; PURINE P2Y1 RECEPTOR; PURINE P2Y4 RECEPTOR; PURINE P2Y6 RECEPTOR; PURINERGIC RECEPTOR AFFECTING AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ASTROCYTOMA CELL; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG SPECIFICITY; GENE EXPRESSION; GLIOMA CELL; HUMAN; HUMAN CELL; MOLECULAR CLONING; RAT; SECOND MESSENGER; SIGNAL TRANSDUCTION;

EID: 0030431414     PISSN: 01441795     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1474-8673.1996.tb00044.x     Document Type: Conference Paper

References (24)

1. BOYER, J.L., LAZAROWSKI, E.R., CHEN, X.H. & HARDEN, T.K. (1993). Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase. J. Pharmacol. Exp. Ther., 267, 1140-1146.
2. 2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y purinoceptors. Br. J. Pharmacol., 113, 614-620.
3. 1 receptor. Mol. Pharmacol., 50, 1323-1329.
4. BRAKE, A.J., WAGENBACH, M.J. & JULIUS, D. (1994). New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature, 371, 519-523.
5. BURNSTOCK, G. & KENNEDY, C. (1985). Is there a basis for distinguishing two types of P2-purinoceptor? Gen. Pharmacol., 16, 433-440.
6. 2 nucleotide receptor. J. Biol. Chem., 270, 26152-26158.
7. COMMUNI, D., PIROTION, S., PARMENTIER, M. & BOLYNAEMS, J.M. (1995). Cloning and functional expression of a human uridine nucleotide receptor. J. Biol. Chem., 270, 30849-30852.
8. 2+ concentration induced by mechanical stimulation is propagated via release of pyrophosphorylated nucleotides in mammary epithelial cells. Pflügers Arch., 427, 533-542.
9. FILIZ, T.A., LI, Q., BOYER, J.L., NICHOLAS, R.A. & HARDEN, T.K. (1994). Expression of a cloned P2Y-purinergic receptor that couples to phospholipase C. Mol. Pharmacol., 46, 8-14.
10. FISCHER, B., BOYER, J.L., HOYLE, C.B., ZIGANSHIN, A.U., BRIZZOHARA, A.L., KNIGHT, G.E., ZIMMET, J., BURNSTOCK, G., HARDEN, T.K. & JACOBSON, K.A. (1993). Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5′-triphosphate. J. Med. Chem., 36, 3937-3946.
11. GOFTZ, U., DA PRADA, M. & PLETSCHER, A. (1971). Adenine-, guanine- and uridine-5′-phosphonucleotides in blood platelets and storage organelles of various species. J. Pharmacol. Exp. Ther., 178, 210-215.
12. LAMBRECHT, G., FRIEBE, T., GRIMM, U., WINDSCHEIF, U., BUNGARDT, E., HILDEBRANDT, C., BAUMERT, H.G., SPATZ KUMBEL, G. & MUTSCHLER, F. (1992). PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur. J. Pharmacol., 217, 217-219.
13. LAZAROWSKI, E.R. & HARDEN, T.K. (1994). Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C. J. Biol. Chem., 269, 11830-11836.
14. LAZAROWSKI, E.R., WATT, W.C., STUTTS, M.L., BOUCHER, R.C. & HARDEN, T.K. (1995). Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br. J. Pharmacol., 116, 1619-1627.
15. LUSTIG, K.D., SHIAU, A.K., BRAKE, A.J. & JULIUS, D. (1993). Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc. Natl. Acad. Sci. USA, 90, 5113-5117.
16. NGUYEN, T., ERB, L., WEISMAN, G.A., MARCHESE, A., HENG, HIL., GARRAD, R.C., GEORGE, S.R., TURNER, J.L. & O'DOWD, B.F. (1995). Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. J. Biol. Chem., 270, 30845-30848.
17. NICHOLAS, R.A., WATT, W.C., LAZAROWSKI, E.R., LI, Q. & HARDEN, T.K. (1996). Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: Identification of a UDP-selective, a UTP-selective, and an ATP- and UTP specific receptor. Mol. Pharmacol., 50, 224-229.
18. 2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc. Natl. Acad. Sci. USA, 91, 13067.
19. RICHARDS, S.M., DORA, K.A., RATLIGAN, S., COIQUHOUN, I.Q. & CLARK, M.G. (1993). Role of extracellular UTP in the release of uracil from vasoconstricted hindlimb. Am. J. Physiol., 264, H233-H237.
20. SALAG, B., BODIN, P., SHACOORI, V., CAIHELINE, M., RUIT, B. & BURNSTOCK, G. (1995). Uptake and flow-induced release of uridine nucleotides from isolated vascular endothelial cells. Endothelium, 2, 279-285.
21. 1-purinergic receptor. Br. J. Pharmacol., 118, 167-173.
22. VALFRA, S., HUSSY, N., EVANS, R.J., ADAMI, N., NORTH, R.A., SURPRENANT, A. & BUHI, G. (1994). A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP. Nature, 371, 516-519.
23. WEBB, L.F., SIMON, J., KRISHER, B.J., BAIESON, A.N., SMART, L.G., KING, B.F., BURNSTOCK, G. & BARNARD, E.A. (1993). Cloning and functional expression of a brain G-protein-coupled ATP receptor. FEBS Lett., 324, 219-225.
24. ZIGANSHIN, A.U., HOYLE, C.H., BO, N., LAMBRECHT, G., MUTSCHLER, F., BAUMERT, H.G. & BURNSTOCK, G. (1993). PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder. Br. J. Pharmacol., 110, 1491-1495.