Stimulation by the nucleotides, ATP and UTP of mitogen-activated protein kinase in EAhy 926 endothelial cells

British Journal of Pharmacology

Volumn 117, Issue 6, 1996, Pages 1341-1347

  Graham, A ^a   McLees, A ^a   Kennedy, C ^a   Gould, G W ^b   Plevin, R ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

ATP; EAhy 926 endothelial cells; MAP kinase; Protein kinase C; UTP

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ADENOSINE TRIPHOSPHATE; EGTAZIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PURINE P2 RECEPTOR; URIDINE TRIPHOSPHATE;

ARTICLE; CATTLE; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 0029983268     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb16734.x     Document Type: Article

References (34)

1. 2-purinergic receptors of aortic endothelial cells with those of adrenal medulla: evidence for heterogeneity of receptor subtype and of inositol phosphate response. Mol. Pharmacol., 38, 84-91.
2. ANDERSON, N.G., MALLER, J.L., TONKS, N.K. & STURGILL, T.W. (1990). Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature, 343, 651-653.
3. 2-purinoceptors on vascular endothelial cells: physiological significance and transduction mechanisms. Trends Pharmacol. Sci., 11, 34-37.
4. BOUTHERIN-FALSON, O., REUSE, S., DUMONT, J.E. & BOEUNAEMS, J.M. (1990). Increased levels of c-fos and c-myc mRNA in ATP-stimulated endothelial cells. Biochem. Biophys. Res. Commun., 172, 306-312.
5. 2+ mobilization by a nucleotide receptor in glomerular endothelial cells. Am. J. Physiol., 266, F210-F217.
6. BURNSTOCK, G. & KENNEDY, C. (1985). Is there a basis for distinguishing two types of P2-purinoceptor? Gen. Pharmacol., 16, 433-440.
7. DAVIS, P.D., HILL, C.H., KEECH, E., LAWTON, G., NIXON, J.S., SEDGWICK, A.D., WADSWORTH, J., WESTMACOTT, D. & WILKINSON, S.E. (1989). Potent selective inhibitors of protein kinase C. FEBS. Lett., 259, 61-63.
8. DAVIS, R.J. (1993). The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem., 268, 14553-14556.
9. DE LEAN, A., MUNSON, P.J. & RODBARD, D. (1980). Simultaneous analysis of a family of sigmoidal curves application to bioassay and physiological dose response curves. Am. J. Physiol., 235, E97-E102.
10. DEMOLLE, D., LECOMTE, M. & BOWYNAEMS, J.M. (1988). Pattern of protein phosphorylation in aortic endothelial cells: modulation by adenine nucleotides and bradykinin. J. Biol. Chem., 263, 18459-18465.
11. EDGELL, C.-J.S., MCDONALD, C.C. & GRAHAM, J.B. (1983). Permanent cell line expressing human factor VIII-related antigen established by hybridisation. Proc. Natl. Acad. Sci. U.S.A., 80, 3734-3737.
12. FLEMING, I., FISSLTHALER, B. & BUSSE, R. (1995). Calcium signalling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases. Circ. Res., 76, 522-529.
13. GORDON, J.L. (1986). Extracellular ATP: effects, sources and fate. Biochem. J., 233, 309-319.
14. GRAHAM, A., MCLEES, A., KENNEDY, C. & PLEVIN, R. (1995). Uridine 5′ triphosphate stimulates mitogen-activated protein kinase in EAhy 926 endothelial cells. Br. J. Pharmacol., 115, 6P.
15. HUWILER, A. & PFEILSCHIFTER, J. (1994). Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells. Br. J. Pharmacol., 113, 1455-1463.
16. KATZ, A., WU, D. & SIMON, M.I. (1992). Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C. Nature, 360, 686-689.
17. KELM, M., FEELISCH, M., SPAHR, R., PIPER, H.M., NOACK, E. & SCHRADER, J. (1988). Quantitative and kinetic characterization of nitric oxide and EDRF released from endothelial cells. Biochem. Biophys. Res. Commun., 154, 236-244.
18. 2-Purinoceptor subtypes-an update. Arch. Pharmacol. Ther., 303, 30-50.
19. KITAZONO, T., TAKESHIGE, K., CRAGOE Jr. E.J. & MINAKAMI, S. (1988). Intracellular pH changes of cultured bovine aortic endothelial cells in response to ATP addition. Biochem. Biophys. Res. Commun., 152, 1304-1309.
20. KOLCH, W., HEIDECKER, G., KOCHS, G., HUMMEL, R., VAHIDI, H., MISCHAK, H., FINKENZELLER, G., MARME, D. & RAPP, U. (1993). Protein kinase Cα activates RAF-1 by direct phosphorylation. Nature, 364, 249-252.
21. MALARKEY, K., BELHAM, C.M., PAUL, A., GRAHAM, A., MCLEES, A., SCOTT, P.H. & PLEVIN, R. (1995). The regulation of tyrosine kinase signalling pathways in response to growth factor and G-protein coupled receptors. Biochem. J., 309, 361-375.
22. MANNIX, R.J., MOATTER, T., KELLEY, K.A. & GERRITSEN, M.E. (1993). Cellular signalling responses mediated by a novel nucleotide receptor in rabbit microvessel endothelium. Am. J. Physiol., 265, H675-H680.
23. MARTIN, W., CUSACK, N.J., CARLETON, J.S. & GORDON, J.L. (1985). Specificity of P2-purinoceptor that mediates endothelium dependent relaxation of the pig aorta. Eur. J. Pharmacol., 108, 295-299.
24. MOTTE, S., PIROTTON, S. & BOEYNAEM, J.M. (1993). Heterogeneity of ATP receptors in aortic endothelial cells. Circ. Res., 72, 504-510.
25. MCLEES, A., GRAHAM, A., MALARKEY, K., GOULD, G.W. & PLEVIN, R. (1995). The regulation of pp42 MAP kinase by protein kinase C-dependent and pertussis toxin sensitive mechanisms in the EAhy 926 endothelial cell line. Biochem. J., 307, 743-748.
26. NEARY, J.T., ZHU, Q. & NORENBERG, M.D. (1994). ATP signalling in astrocytes: activation of MAP kinase. Drug Dev. Res., 31, 302.
27. NEEDHAM, L., CUSACK, N.J., PEARSON, J.D. & GORDON, J.L. (1987). Characteristics of the P2 purinoceptor that mediates prostacyclin production by pig aortic endothelial cells. Eur. J. Pharmacol., 134, 199-209.
28. O'CONNOR, S.E., DAINTY, I.A. & LEFF. (1991). Further subclassification of ATP receptors based on agonist studies. Trends Pharmacol. Sci., 12, 137-141.
29. PEARSON, J.D., SLAKEY, L.L. & GORDON, J.L. (1983). Stimulation of prostaglandin production through purinoceptors on cultured porcine endothelial cells. Biochem, J., 214, 273-276.
30. PFEILSCHIFTER, J. & MERRIWEATHER, C. (1993). Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C-ε in rat renal mesangial cells. Br. J. Pharmacol., 110, 847-853.
31. PURKISS, J.R., WILKINSON, G.F. & BOARDER, M.R. (1993). Evidence for a nucelotide receptor on adrenal medullary endothelial cells linked to phospholipase C and phospholipase D. Br. J. Pharmacol., 108, 1031-1037.
32. fak) in rat-1 fibroblasts. Biochem. J., 301, 407-414.
33. THOMAS, G. (1992). MAP kinase by any other name smells just as sweet. Cell, 68, 3-6.
34. VAN DAELE, P., VAN COEVORDEN, A., ROGER, P.P. & BOEYNAEMS, J.-M. (1992). Effects of adenine nucleotides on the proliferation of aortic endothelial cells. Circ. Res., 70, 82-90.