Oxidative stress and signal transduction in Saccharomyces cerevisiae: Insights into ageing, apoptosis and diseases

Molecular Aspects of Medicine

Volumn 22, Issue 4-5, 2001, Pages 217-246

  Costa, Vitor ^a,b   Moradas Ferreira, Pedro ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Ageing; Amyotrophic lateral sclerosis; Apoptosis; Friedreich's ataxia; Gene regulation; Oxidative stress; Saccharomyces cerevisiae; Signal transduction

Indexed keywords

ALCOHOL; METAL ION; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR;

AGING; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; CELL METABOLISM; DEFENSE MECHANISM; DNA DAMAGE; FRIEDREICH ATAXIA; GENE CONTROL; GENE EXPRESSION; HEAT SHOCK; HUMAN; LIPID PEROXIDATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; REGULATORY MECHANISM; REVIEW; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; YEAST CELL;

AGING; ANIMALS; APOPTOSIS; DISEASE; HUMANS; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EID: 0034777854     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0098-2997(01)00012-7     Document Type: Review

References (133)

1. Iron-dependent self-assembly of recombinant yeast frataxin: Implications for Friedreich ataxia
2. 0 cells of Saccaromyces cerevisiae depends on the state rather than rate of respiration and is enhanced in pos9 but not yap1 mutants
3. Global gene expression during short term ethanol stress in Saccharomyces cerevisiae
4. 1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide
5. The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast
6. Changes of telomere lenght cause reciprocal changes in the lifespan of Saccharomyces cerevisiae
7. Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin
8. Effect of Cu, Zn superoxide dismutase disruption mutation on replicative senescence in Saccharomyces cerevisiae
9. Trehalose accumulation during cellular stress protects cells and cellular proteins from damage by oxygen radicals
10. Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast
11. Msn2p and Msn4p control a large number of genes induced at the diauxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae
12. Yeast and human frataxin are processed to mature form in two sequential steps by the mitochondrial processing peptidase
13. Oxidative mutagens induce intrachromosomal recombination in yeast
14. Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae
15. Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae
16. Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces cerevisiae
17. The mitochondrial cytochrome c peroxidase Ccp1 of Saccharomyces cerevisiae is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7)
18. CCC1 suppresses mitochondrial damage in the yeast model of Friedreich's ataxia by limiting mitochondrial iron accumulation
19. Yap1p activates gene transcription in an oxidant-specific fashion
20. Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae
21. Oxidative stress and iron are implicated in fragmenting vacuoles of Saccharomyces cerevisiae lacking Cu,Zn-superoxide dismutase
22. Acquisition of ethanol tolerance in Saccharomyces cerevisiae: The key role of the mitochondrial superoxide dismutase
23. Mitochondrial superoxide dismutase is essential for ethanol tolerance of Saccharomyces cerevisiae in the post-diauxic phase
24. Effects of anoxia and the mitochondrion on the expression of aerobic nuclear COX genes in yeast-evidence for a signaling pathway from the mitochondrial genome to the nucleus
25. Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae
26. Cytotoxic and genotoxic consequences of heat stress are dependent on the presence of oxygen in Saccharomyces cerevisiae
27. Yeast lacking Cu-Zn superoxide dismutase show altered iron homeostasis. Role of oxidative stress in iron metabolism
28. Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids
29. 2-stress conditions: The role of yap1p in cell proliferation control in yeast
30. Stress-controlled transcription factors, stress-induced genes and stress tolerance in budding yeast
31. Regulation of longevity and stress resistance by sch9 in yeast
32. Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions
33. 1 arrest independent of RAD9 function
34. Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain
35. Mechanisms of oxygen radiosensitization in irradiated yeast. I. DNA double-strand breakage
36. Apoptosis in yeast - A monocellular organism exhibits altruistic behaviour
37. Carbon catabolite repression in yeast
38. Hyperphosphorylation of Msn2p and Msn4p in response to heat shock and the diauxic shift is inhibited by cAMP in Saccharomyces cerevisiae
39. Genomic expression programs in the response of yeast cells to environmental changes
40. Synergism between base excision repair, mediated by the DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae
41. Repair of oxidized DNA bases in the yeast Saccharomyces cerevisiae
42. 2 stimulon in Saccharomyces cerevisiae
43. 2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity
44. Loss in vitro metal ion binding secificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis
45. Differential protein S-thiolation of glyceraldehyde-3-phosphate dehydrogenase isoenzymes influences sensitivity to oxidative stress
46. Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae
47. BCL-2 family members and the mitochondria in apoptosis
48. Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL-XL
49. Nuclear import of the yeast AP-1-like transcription factor Yap1p is mediated by transport receptor Pse1p, and this import step is not affected by oxidative stress
50. Oxidative stress response in yeast: Effect of glutathione on adaptation to hydrogen peroxide stress in Saccharomyces cerevisiae
51. Thioredoxin deficiency causes the constitutive activation of yap1, an AP-1-like transcription factor in Saccharomyces cerevisiae
52. Oxidative stress responses of the yeast Saccharomyces cerevisiae
53. Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress
54. The essential protein fap7 is involved in the oxidative stress response of Saccharomyces cerevisiae
55. A novel plant glutathione S-transferase/peroxidase suppresses Bax lethality in yeast
56. Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: Excision of guanine lesions produced in DNA by ionizing radiation- or hydrogen peroxide/metal ion-generated free radicals
57. Mitochondrial permeability transition and oxidative stress
58. Mt-Hsp70 homolog, Ssc2p, required for maturation of yeast frataxin and mitochondrial iron homeostasis
59. The response regulator-like protein Pos9/Skn7 of Saccharomyces cerevisiae is involved in oxidative stress resistance
60. YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides
61. Regulation of yAP-1 nuclear localization in response to oxidative stress
62. Crm1p (Xpo1) dependent nuclear localisation in response to oxidative stress
63. Regulation of the yeast Yap1p nuclear export signal is mediated by redox signal-induced reversible disulfide bond formation
64. Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast
65. Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis
66. Yap1 and skn7 control two specialized oxidative stress response regulons in yeast
67. A yeast mutant lacking thiol-dependent protector protein is hypersensitive to menadione
68. The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain
69. Carbonyl assays for determination of oxidatively modified proteins
70. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
71. Enhanced gluconeogenesis and increased energy storage as hallmarks of aging in Saccharomyces cerevisiae
72. Genome-wide transcriptional analysis of aerobic and anaerobic chemostat cultures of Saccharomyces cerevisiae
73. Transcript analysis of 203 novel genes from Saccharomyces cerevisiae in hap1 and rox1 mutant backgrounds
74. Mitochondrial superoxide decreases yeast survival in stationary phase
75. Chronological lifespan of stationary phase yeast cells; a model for investigating the factors that might influence the ageing of postmitotic tissues in higher organisms
76. A yeast mutant showing diagnostic markers of early and late apoptosis in yeast
77. Oxygen stress: A regulator of apoptosis in yeast
78. Release of cytochrome c and decrease of cytochrome c oxidase in Bax-expressing yeast cells, and prevention of these effects by coexpression of Bcl-XL
79. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
80. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress-response element (STRE)
81. Mitochondrial F0F1-ATPase proton-pump is required for function of pro-apoptotic protein Bax in yeast and mammalian cells
82. Yeast as a tool for apoptosis research
83. Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA
84. Bcl-XL regulates apoptosis by heterodimerization-dependent and independent mechanisms
85. Adaptive response of the yeast Saccharomyces cerevisiae to reactive oxygen species: Defences, damage and death
86. The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae
87. The yeast peptide methionine sulfoxide reductase functions as an antioxidant in vivo
88. The influence of oxygen toxicity on yeast mother cell-specific aging
89. Characterization of three copper-zinc superoxide dismutase mutants analogous to those coded for in familial amyotrophiclateral sclerosis
90. Saccharomyces cerevisiae cultured under aerobic and anaerobic conditions: Air-level oxygen stress and protection against stress
91. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
92. Friedreich ataxia: From GAA triplet-repeat expansion to frataxin deficiency
93. Heme regulates SOD2 transcription by activation and repression in Saccharomyces cerevisiae
94. Comparison of the effects of bax-expression in yeast under fermentative and respiratory conditions: Investigation of the role of adenine nucleotides carrier and cytochrome c
95. Investigation of bax-induced release of cytochrome c from yeast mitochondria. Permeability of mitochondrial membranes, role of VDAC and ATP requirement
96. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from antiapoptotic gene to proapoptotic gene: Studies in yeast and neural cells
97. The yeast frataxin homologue mediates mitochondrial iron efflux. Evidence for a mitochondrial iron cycle
98. The Skn7 response regulator of Saccharomyces cerevisiae interacts with Hsf1 in vivo and is required for the induction of heat shock genes by oxidative stress
99. Mutations in Cu/zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
100. Thioredoxin peroxidase is required for the transcriptional response to oxidative stress in budding yeast
101. A cytochrome c-GFP fusion is not released from the mitochondria into the cytoplasm upon expression of Bax in yeast cells
102. Regulation of yeast catalase genes
103. Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae
104. The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of Saccharomyces cerevisiae CTT1 gene
105. A mutation in a mitochondrial ABC transporter results in mitochondrial dysfunction through oxidative damage of mitochondrial DNA
106. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
107. Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator
108. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis
109. Aging in Saccharomyces cerevisiae
110. Mitochondria in the programmed death phenomena; a principle of biology: It is better to die than to be wrong
111. Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation
112. Yeast lacking superoxide dismutase(s) show elevated levels of free iron as measured by whole cell electron paramagnetic resonance
113. Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions
114. Mechanisms and genes of cellular suicide
115. A fraction of yeast Cu/Zn superoxide dismutase and its mettalochaperone, CCS, localize to the intermembrane space of mitochondria: A physiological role for SOD1 in guarding against mitochondrial oxidative stress
116. The Yap1p-dependent induction of glutathione synthesis in heat shock response of Saccharomyces cerevisiae
117. Role of glutathione in heat-shock-induced cell death of Saccharomyces cerevisiae
118. Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae
119. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae
120. AP-1transcription factors in yeast
121. Redox control of AP-1-like factors in yeast and beyond
122. Saccharomyces cerevisiae exhibits a yAP-1-mediated adaptive response to malondialdehyde
123. ′ exonuclease activities of yeast Apn2 protein and requirement of these activities for repair of oxidative DNA damage
124. Bcl-xl prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exhange
125. Accumulation of single-strand breaks is the major cause of telomere shortening
126. Deficiency in superoxide dismutases shortens life span of yeast cells
127. 2 and diamide
128. Increased stress parameter synthesis in the yeast Saccharomyces cerevisiae after treatment with 4-hydroxy-2-nonenal
129. Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor
130. Saccharomyces cerevisiae Ntg1p and Ntg2p: Broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria
131. Molecular mechanism of heme signaling in yeast: The transcriptional activator Hap1 serves as the key mediator