Synergism between base excision repair, mediated by the DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae

Molecular Genetics and Genomics

Volumn 265, Issue 6, 2001, Pages 1087-1096

  Gellon, L ^a   Barbey, R ^b   Van der Kemp, P Auffret ^a   Thomas, D ^b   Boiteux, S ^a  

^a INSTITUT DE RADIOBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

^b CENTRE DE GÉNÉTIQUE MOLÉCULAIRE   (France)

Author keywords

DNA repair and mutagenesis; NTG1 NTG2 RAD1 RAD14; Oxidative damage; Saccharomyces cerevisiae

Indexed keywords

BUTYL HYDROPEROXIDE; DNA BASE; DNA GLYCOSYLTRANSFERASE; HYDROGEN PEROXIDE; LYSINE; MENADIONE; NUCLEOTIDE; PROTEIN NTG1; PROTEIN NTG2; PROTEIN RAD1; PROTEIN RAD14; PYRIMIDINE; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; DNA DAMAGE; DNA REPAIR; ENZYME INACTIVATION; EXCISION REPAIR; GENE MUTATION; IRRADIATION; MUTAGENESIS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STRAIN DIFFERENCE;

SACCHAROMYCES CEREVISIAE;

EID: 0034922788     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380100507     Document Type: Article

References (53)

1. The Saccharomyces cerevisiae homologs of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast
2. Purification, characterization, gene cloning, and expression of Saccharomyces cerevisiae redoxyendonuclease, a homolog of Escherichia coli endonuclease III
3. Genetic effects of thymine glycol: Site-specific mutagenesis and molecular modeling studies
4. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae
5. The Saccharomyces cerevisiae ETH1 gene, an inducible homolog of exonuclease III that provides resistance to DNA-damaging agents and limits spontaneous mutagenesis
6. Properties and biological functions of the NTH and FPG proteins of Escherichia coli: Two DNA glycosylases that repair oxidative damage in DNA
7. The human OGG1 gene: Structure, functions, and its implication in the process of carcinogenesis
8. Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): Excision of purine lesions in DNA produced by ionizing radiation or photosensitization
9. A family of low and high copy replicative, integrative and single-stranded S. cerevisiae/E. coli shuttle vectors
10. Oxidative damage to DNA: Formation, measurement, and biological significance
11. A similar defect in UV-induced mutagenesis conferred by the rad6 and rad18 mutations of Saccharomyces cerevisiae
12. Evidence for short-patch mismatch repair in Saccharomyces cerevisiae
13. Regulation of bacterial oxidative stress genes
14. Chemical determination of free radical-induced damage to DNA
15. Substrate specificity of the Escherichia coli endonuclease III: Excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals
16. Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli
17. Reactive oxygen species in tumorigenesis
18. Removal of nonhomologous DNA ends in double-strand break recombination: The role of the yeast ultraviolet repair gene RAD1
19. Hydrogen peroxide causes RAD9-dependent cell cycle arrest in G2 in Saccharomyces cerevisiae whereas menadione causes G1 arrest independent of RAD9 function
20. Improved method for high efficiency transformation of intact yeast cells
21. Repair of oxidized DNA bases in the yeast Saccharomyces cerevisiae
22. Catalytic and DNA binding properties of the Ogg1 protein of Saccharomyces cerevisiae: Comparison between the wild type and the K241R and K241Q active-site mutant proteins
23. Hybridization probe size control: Optimized 'oligolabelling'
24. A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli
25. Escherichia coli endonuclease VIII: Cloning, sequencing, and overexpression of the nei structural gene and characterization of nei and nei nth mutants
26. Characterization of Escherichia coli endonuclease VIII
27. Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites
28. Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: Excision of guanine lesions produced in DNA by ionizing radiation- or hydrogen peroxide/metal ion-generated free radicals
29. Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins
30. UvrABC nuclease complex repairs thymine glycol, an oxidative DNA base damage
31. DNA glycosylases in the base excision repair of DNA
32. The influence of formamidopyrimidine-DNA glycosylase on the spontaneous and gamma-radiation-induced mutation spectrum of the lacZ alpha gene
33. The distribution of the numbers of mutants in bacterial populations
34. Transcription-coupled repair of 8-oxoguanine: Requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome
35. A new mechanism for repairing oxidative damage to DNA: (A)BC excinuclease removes AP sites and thymine glycols from DNA
36. Quality control by DNA repair
37. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
38. Initiation of base excision repair: Glycosylase mechanisms and structures
39. Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe
40. Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily
41. The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage
42. Cellular role of yeast Apn1 apurinic endonuclease/3′-diesterase: Repair of oxidative and alkylation DNA damage and control of spontaneous mutation
43. Characterization of endonuclease III (nth) and endonuclease VIII (nei) mutants of Escherichia coli K-12
44. Spontaneous mutation, oxidative DNA damage, and the roles of base and nucleotide excision repair in the yeast Saccharomyces cerevisiae
45. Substrate specificities of the Ntg1 and Ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical
46. Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae
47. Inactivation of OGG1 increases the incidence of GC→TA transversions in Saccharomyces cerevisiae: Evidence for endogenous oxidative damage to DNA in eukaryotic cells
48. Evidence for the involvement of nucleotide excision repair in the removal of abasic sites in yeast
49. Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine
50. Synergism between yeast nucleotide and base excision repair pathways in the protection against DNA methylation damage
51. Saccharomyces cerevisiae possesses two functional homologues of Escherichia coli endonuclease III
52. Saccharomyces cerevisiae Ntg1p and Ntg2p: Broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria