3′-phosphodiesterase and 3′ → 5′ exonuclease activities of yeast Apn2 protein and requirement of these activities for repair of oxidative DNA damage

Molecular and Cellular Biology

Volumn 21, Issue 5, 2001, Pages 1656-1661

  Unk, I ^a   Haracska, L ^a   Prakash, S ^a   Prakash, L ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; EXONUCLEASE; PHOSPHODIESTERASE; 3' NUCLEOTIDASE; 3'-NUCLEOTIDASE; ALANINE; APN2 PROTEIN, S CEREVISIAE; DEOXYRIBONUCLEASE IV; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; EXODEOXYRIBONUCLEASE; EXODEOXYRIBONUCLEASE V; GLUTAMIC ACID; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; LYASE; NUCLEOTIDASE; OXYGEN; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; BINDING SITE; CHEMISTRY; DNA DAMAGE; DOSE RESPONSE; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PH; PHYSIOLOGY; TIME;

SACCHAROMYCES CEREVISIAE;

ALANINE; BASE SEQUENCE; BINDING SITES; CARBON-OXYGEN LYASES; DEOXYRIBONUCLEASE IV (PHAGE T4-INDUCED); DNA DAMAGE; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXODEOXYRIBONUCLEASE V; EXODEOXYRIBONUCLEASES; GLUTAMIC ACID; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEOTIDASES; OXYGEN; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 0034746231     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.5.1656-1661.2001     Document Type: Article

References (15)

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2. 2-damaged Escherichia coli
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4. DNA damage and oxygen radical toxicity
5. Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites
6. Rate of depurination of native deoxyribonucleic acid
7. DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination
8. Structure and function of the multifunctional DNA-repair enzyme exonuclease III
9. The base excision repair pathway
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11. Apurinic endonuclease activity of yeast Apn2 protein
12. A convenient synthesis of oligonucleotides with a 3′-phosphoglycolate and 3′-phosphoglycaldehyde terminus
13. Oxidative damage to DNA and its repair
14. Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA
15. Removal of 3′-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1