Co-stimulatory effect of nitric oxide on endothelial NF-κB implies a physiological self-amplifying mechanism

European Journal of Immunology

Volumn 28, Issue 8, 1998, Pages 2276-2282

  Umansky, Victor ^a   Hehner, Steffen P ^a   Dumont, Andreas ^a   Hofmann, Thomas G ^a   Schirrmacher, Volker ^a   Dröge, Wulf ^a   Schmitz, M Lienhard ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Endothelial cell; Gene regulation; I B kinase; NF B; Nitric oxide

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; AUTOREGULATION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SECOND MESSENGER; TRANSACTIVATION;

ANIMALS; APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; ENDOTHELIUM; GENE EXPRESSION REGULATION; GENES, REPORTER; I-KAPPA B KINASE; INFLAMMATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUCIFERASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031927265     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199808)28:08<2276::AID-IMMU2276>3.0.CO;2-H     Document Type: Article

References (34)

1. Mantovani, A., Bussolino, F. and lntrona, M., Cytokine regulation of endothelial cell function: from molecular level to the bedside. Immunol. Today 1997. 18: 231-240.
2. Moncada, S., Palmer, R. J. and Higgs, E. A., Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 1991. 43: 109-142.
3. Suschek, C., Rothe, H., Fehsel, K., Enczmann, J. and Kolb-Bachofen, V., Induction of a macrophage-like nitric oxide synthase in cultured rat aortic endothelial cells. IL-1β-mediated induction regulated by TNF-α and IFN-γ. J. Immunol. 1993. 151: 3283-3291.
4. Rees, D., Palmer, R. and Moncada, S., Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl. Acad. Sci. USA 1989. 86: 3375-3378.
5. Fehsel, K., Krönke, K. D., Meyer, K. L., Huber, H., Wahn, V. and Kolb-Bachofen, V., Nitric oxide induces apoptosis in mouse thymocytes. J. Immunol. 1995. 155: 2858-2865.
6. Umansky, V., Bucur, M., Schirrmacher, V. and Rocha, M., Activated endothelial cells induce apoptosis in lymphoma cells: Role of nitric oxide. Int. J. Oncol. 1997. 10: 465-471.
7. Geng, Y.-J., Hellstrand, K., Wennmalm, A. and Hansson, G. K., Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to γ-interferon and TNF-α. Cancer Res. 1996. 56: 866-874.
8. Xie, Q.-W., Kashiwabara, Y. and Nathan, C., Role of transcription factor NF-(greek small letter script kappa)B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 1994. 269: 4705-4708.
9. Dong, Z., Qi, X., Xie, K. and Fidler, I. J., Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages. J. Immunol. 1993. 151: 2717-2724.
10. Umansky, V., Shatrov, V. A., Lehmann, V. and Schirrmacher, V., Induction of NO synthesis in macrophages by Newcastle disease virus is associated with activation of nuclear factor (greek small letter script kappa)B. Int. Immunol. 1996. 8: 491-498.
11. Grilli, M., Chiu, J. J. and Lenardo, M. J., NF-(greek small letter script kappa)B and relparticipants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 1993. 143: 1-62.
12. Schmitz, M. L. and Baeuerle, P. A., Multi-step activation of NF-(greek small letter script kappa)B/Rel transcription factors. Immunobiology 1995. 193: 116-127.
13. Baldwin, A. S., The NF-(greek small letter script kappa)B and I(greek small letter script kappa)B proteins: new discoveries and insights. Annu. Rev. Immunol. 1996. 14: 649-683.
14. Israël, A., A role for phosphorylation and degradation in the control of NF-(greek small letter script kappa)B activity. Trends Genet 1995. 11: 203-205.
15. Baeuerle, P. A., Last pieces in the NF-(greek small letter script kappa)B puzzle? Curr. Biol. 1998. 8: R19-R22.
16. Stancovski, I. and Baltimore, D., NF-(greek small letter script kappa)B activation: The I(greek small letter script kappa)B kinase revealed? Cell 1997. 91: 299-302.
17. Schmidt, K. N., Amstad, P., Cerutti, P. and Baeuerle, P. A., Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-(greek small letter script kappa)B. Adv. Exp. Med. Biol. 1996. 387: 63-68.
18. Cahill, M. A., Janknecht, R. and Nordheim, A., Signalling pathways: Jack of all cascades. Curr. Biol. 1996. 6: R16-R19.
19. ras. J. Biol. Chem. 1995. 270: 7017-7020.
20. Matthews, J. R., Botting, C. H., Panico, M., Morris, H. R. and Hay, R. T., Inhibition of NF-(greek small letter script kappa)B DNA binding by nitric oxide. Nucleic Acids Res. 1996. 24: 2236-2242.
21. Peng, H.-B., Libby, P. and Liao, J. K., Induction and stabilization of I(greek small letter script kappa)B-α by nitric oxide mediates inhibition of NF-(greek small letter script kappa)B. J. Biol. Chem. 1995. 270: 14214-14219.
22. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E. and Karin, M., A cytokine-responsive kinase that activates the transcription factor NF-(greek small letter script kappa)B. Nature 1997. 388: 548-554.
23. Minden, A., Lin, A., Claret, F.-X., Abo, A. and Karin, M., Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 1995. 81: 1147-1157.
24. Park, D. S., Stefanis, L., Van, C. Y. I., Farinelli, S. E. and Greene., L. A., Ordering the cell death pathway. Differential effects of Bcl-2, an interleukin-1 converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells. J. Biol. Chem. 1996. 271: 21898-21905.
25. Lo, Y. Y. C., Wong, J. M. S. and Cruz, T. F., Reactive oxygen species mediate cytokine activation of c-Jun terminal kinases. J. Biol. Chem. 1996. 271: 15703-15707.
26. Krönke, K. D., Brenner, H. H., Rodriguez, M. L., Etzkorn, K., Noack, E. A., Kolb, H. and Kolb-Bachofen, V., Pancreatic islet cells are highly susceptible towards the cytototoxic effects of chemically generated nitric oxide. Biochim. Biophys. Acta 1993. 1182: 221-229.
27. Sano, H., Hirai, M., Saito, H., Nakashima, I. and Isobe, K., Nitric oxide releasing agent, S-nitroso-N-acetylpenicillamine, enhances the expression of manganese Superoxide dismutase mRNA in rat vascular smooth muscle cells. J. Cell. Biochem. 1996. 62: 50-55.
28. Pfeilschifter, J. and Huwiler, A., Nitric oxide stimulates stress-activated protein kinases in glomerular endothelial and mesangial cells. FEBS Lett. 1996. 396: 67-70.
29. al Moustafa, A. E. and Chalifour, L. E., Immortal cell lines isolated from heart differentiate to an endothelial cell lineage in the presence of retinoic acid. Cell Growth Differ. 1993. 4: 841-847.
30. De Bosscher, K., Schmitz, M. L., Vanden Berghe, W., Plaisance, S., Fiers, W. and Haegeman, G., Glucocorticoid-mediated repression of nuclear factor-(greek small letter script kappa)B-dependent transcription involves direct interference with transactivation. Proc. Natl. Acad. Sci. USA 1997. 94: 13504-13509.
31. Hehner, S. P., Heinrich, M., Bork, P. M., Vogt, M., Ratter, F., Lehmann, V., Schulze-Osthoff, K., Dröge, W. and Schmitz, M. L., Sequiterpene lactones specifically inhibit activation of NF-(greek small letter script kappa)B by preventing the degradation of I(greek small letter script kappa)B-α and I(greek small letter script kappa)-β. J. Biol. Chem. 1998. 273: 1288-1297.
32. Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Man, J., Ulevitch, R. J. and Davis, R. J., Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 1995. 267: 682-685.
33. 15N) nitrate in biological fluids. Anal. Biochem. 1982. 126: 131-138.
34. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. and Riccardi, C., A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 1991. 139: 271-279.