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Volumn 380, Issue 2, 1999, Pages 117-128

The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins

Author keywords

BAP 1; BARD1; BRCA1; BRCT; Breast cancer; Cell cycle; DNA repair; Mutation; Ovarian cancer; Transcriptional transactivation

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; MYC PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN P53; RNA HELICASE; RNA POLYMERASE II;

EID: 0032982976     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.1999.019     Document Type: Review
Times cited : (57)

References (88)
  • 1
    • 0028848589 scopus 로고
    • Mouse brca1 localization, sequence analysis and identification of evolutionarily conserved domains
    • Abel, K.J., Xu, J., Yin, G-Y., Lyons, R.H., Meisler, M.H., and Weber, B.L. (1995). Mouse Brca1 localization, sequence analysis and identification of evolutionarily conserved domains. Hum. Mol. Genet. 4, 2265-2273.
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 2265-2273
    • Abel, K.J.1    Xu, J.2    Yin, G.-Y.3    Lyons, R.H.4    Meisler, M.H.5    Weber, B.L.6
  • 2
    • 0031830844 scopus 로고    scopus 로고
    • BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A
    • Anderson, S.F., Schlegel, B.P., Nakajima, T., Wolpin, E.S., and Parvin, J.D. (1998). BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat. Genet. 19, 254-256.
    • (1998) Nat. Genet. , vol.19 , pp. 254-256
    • Anderson, S.F.1    Schlegel, B.P.2    Nakajima, T.3    Wolpin, E.S.4    Parvin, J.D.5
  • 4
    • 0032558734 scopus 로고    scopus 로고
    • Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein
    • Ayi, T.-C., Tsan, J.T., Hwang L.-Y., Bowcock, A.M., and Baer, R. (1998). Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein. Oncogene 17, 2143-2148.
    • (1998) Oncogene , vol.17 , pp. 2143-2148
    • Ayi, T.-C.1    Tsan, J.T.2    Hwang, L.-Y.3    Bowcock, A.M.4    Baer, R.5
  • 5
    • 0031832736 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: From molecular genetics to clinical medicine
    • Blackwood, M.A., and Weber, B.L. (1998). BRCA1 and BRCA2: from molecular genetics to clinical medicine. J. Clin. Onc. 16, 1969-1977.
    • (1998) J. Clin. Onc. , vol.16 , pp. 1969-1977
    • Blackwood, M.A.1    Weber, B.L.2
  • 6
    • 0031046294 scopus 로고    scopus 로고
    • A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
    • Bork, P., Hofmann, K., Bucher, P., Neuwald, A.F., Altschul, S.F., and Koonin, E.V. (1997). A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11, 68-76.
    • (1997) FASEB J. , vol.11 , pp. 68-76
    • Bork, P.1    Hofmann, K.2    Bucher, P.3    Neuwald, A.F.4    Altschul, S.F.5    Koonin, E.V.6
  • 8
    • 0027509346 scopus 로고
    • A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis
    • Boyd, J.M., Subramanian, T., Schaeper, U., La Regina, M., Bayley, S., and Chinnadurai, G. (1993). A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. EMBO J. 12, 469-478.
    • (1993) EMBO J. , vol.12 , pp. 469-478
    • Boyd, J.M.1    Subramanian, T.2    Schaeper, U.3    La Regina, M.4    Bayley, S.5    Chinnadurai, G.6
  • 10
    • 0031031787 scopus 로고    scopus 로고
    • From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair
    • Callebaut, I., and Mornon, J-P. (1997). From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400, 25-30.
    • (1997) FEBS Lett. , vol.400 , pp. 25-30
    • Callebaut, I.1    Mornon, J.-P.2
  • 11
    • 0030970137 scopus 로고    scopus 로고
    • The BRCA1 and BRCA2 breast cancer genes
    • Casey, G. (1997). The BRCA1 and BRCA2 breast cancer genes. Curr. Opin. Oncol. 9, 88-93.
    • (1997) Curr. Opin. Oncol. , vol.9 , pp. 88-93
    • Casey, G.1
  • 12
    • 0028148889 scopus 로고
    • Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer
    • Castilla, L.H., Couch, F.J., Erdos, M.R., Koskins, K.F., Calzone, K., Garber et al. (1994). Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. Nat. Genet. 8, 387-391.
    • (1994) Nat. Genet. , vol.8 , pp. 387-391
    • Castilla, L.H.1    Couch, F.J.2    Erdos, M.R.3    Koskins, K.F.4    Calzone, K.5    Garber6
  • 13
    • 0029830051 scopus 로고    scopus 로고
    • Transcriptional activation by BRCA1
    • Chapman, M.S., and Verma, I.M. (1996). Transcriptional activation by BRCA1. Nature 382, 678-679.
    • (1996) Nature , vol.382 , pp. 678-679
    • Chapman, M.S.1    Verma, I.M.2
  • 14
    • 0032159062 scopus 로고    scopus 로고
    • Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
    • Chen, J., Silver, D.P., Walpita, D., Cantor, S.B., Gazdar, A.F., Tomlinson et al. (1998). Stable Interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2, 317-328.
    • (1998) Mol. Cell , vol.2 , pp. 317-328
    • Chen, J.1    Silver, D.P.2    Walpita, D.3    Cantor, S.B.4    Gazdar, A.F.5    Tomlinson6
  • 15
    • 0029987651 scopus 로고    scopus 로고
    • BRCA1 is a 220 kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner
    • Chen, Y., Farmer, A.A., Chen, C.-F., Jones, D.C., Chen, P-L. and W.-H. Lee (1996). BRCA1 is a 220 kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res. 56, 3168-3172.
    • (1996) Cancer Res. , vol.56 , pp. 3168-3172
    • Chen, Y.1    Farmer, A.A.2    Chen, C.-F.3    Jones, D.C.4    Chen, P.-L.5    Lee, W.-H.6
  • 17
    • 0032580696 scopus 로고    scopus 로고
    • Low frequency of lymph-node metastasis in BRCA1-associated breast cancer
    • Eisinger, F., Nogues, C., Birnbaum, D., Jacquemier, J., and Sobol, H. (1998). Low frequency of lymph-node metastasis in BRCA1-associated breast cancer. Lancet 351, 1633-1634.
    • (1998) Lancet , vol.351 , pp. 1633-1634
    • Eisinger, F.1    Nogues, C.2    Birnbaum, D.3    Jacquemier, J.4    Sobol, H.5
  • 18
    • 0030013201 scopus 로고    scopus 로고
    • Relationships between DNA repair and transcription
    • Friedberg, E.C. (1996). Relationships between DNA repair and transcription. Ann. Rev. Biochem. 65, 15-42.
    • (1996) Ann. Rev. Biochem. , vol.65 , pp. 15-42
    • Friedberg, E.C.1
  • 19
    • 0028034348 scopus 로고
    • Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families
    • Friedman, L.S., Ostermeyer, E.A., Szabo, S., Dowd, P., Lynch, E.D., Rowell, S.E., and King, M.-C. (1994). Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families. Nat. Genet. 8, 399-404.
    • (1994) Nat. Genet. , vol.8 , pp. 399-404
    • Friedman, L.S.1    Ostermeyer, E.A.2    Szabo, S.3    Dowd, P.4    Lynch, E.D.5    Rowell, S.E.6    King, M.-C.7
  • 20
    • 0031803226 scopus 로고    scopus 로고
    • Response to radiation therapy and prognosis in breast cancer patients with BRCA1 and BRCA2 mutations
    • Gaffney, D.K., Brohet, R.M., Lewis, C.M., Holden, J.A., Buy, S.S., Neuhausen, S.L., et al. (1998). Response to radiation therapy and prognosis in breast cancer patients with BRCA1 and BRCA2 mutations. Radiother. Oncol. 47, 129-136.
    • (1998) Radiother. Oncol. , vol.47 , pp. 129-136
    • Gaffney, D.K.1    Brohet, R.M.2    Lewis, C.M.3    Holden, J.A.4    Buy, S.S.5    Neuhausen, S.L.6
  • 21
    • 0028844202 scopus 로고
    • Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation
    • Gayther, S.A., Warren, W., Mazoyer, S., Russell, P.A., Harrington, P.A., Chiano, M., et al. (1995). Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation. Nat. Genet. 11, 428-433.
    • (1995) Nat. Genet. , vol.11 , pp. 428-433
    • Gayther, S.A.1    Warren, W.2    Mazoyer, S.3    Russell, P.A.4    Harrington, P.A.5    Chiano, M.6
  • 22
    • 0030051903 scopus 로고    scopus 로고
    • Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
    • Gowen, L.C., Johnson, B.L., Latour, A.M., Sulik, K.K., and Koller, B.H. (1996). Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat. Genet. 12, 191-194.
    • (1996) Nat. Genet. , vol.12 , pp. 191-194
    • Gowen, L.C.1    Johnson, B.L.2    Latour, A.M.3    Sulik, K.K.4    Koller, B.H.5
  • 23
    • 0032516654 scopus 로고    scopus 로고
    • BRCA1 required for transcription-coupled repair of oxidative DNA damage
    • Gowen, L.C., Avrutskaya, A.V., Latour, A.M., Koller, B.H., and Leadon, S.A. (1998). BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science 281, 1009-1012.
    • (1998) Science , vol.281 , pp. 1009-1012
    • Gowen, L.C.1    Avrutskaya, A.V.2    Latour, A.M.3    Koller, B.H.4    Leadon, S.A.5
  • 25
    • 15844371372 scopus 로고    scopus 로고
    • The tumor suppressor gene BRCA1 is required for embryonic cellular proliferation in the mouse
    • Hakem, R., de la Pompa, J.L., Sirard, C., Mo, R., Woo, M., Hakem, A. et al. (1996). The tumor suppressor gene BRCA1 is required for embryonic cellular proliferation in the mouse. Cell 85, 1009-1023.
    • (1996) Cell , vol.85 , pp. 1009-1023
    • Hakem, R.1    De La Pompa, J.L.2    Sirard, C.3    Mo, R.4    Woo, M.5    Hakem, A.6
  • 27
    • 2142721332 scopus 로고    scopus 로고
    • Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers
    • Hao Thai, T.H., Du, F., Tsan, J.T., Jin, Y., Phung, A., Spillman, M.A., et al. (1998). Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers. Hum. Mol. Genet. 7, 195-202.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 195-202
    • Hao Thai, T.H.1    Du, F.2    Tsan, J.T.3    Jin, Y.4    Phung, A.5    Spillman, M.A.6
  • 30
    • 0032573068 scopus 로고    scopus 로고
    • BRCA1 is associated with the centrosome during mitosis
    • Hsu, L.-C., and White, R.L. (1998). BRCA1 is associated with the centrosome during mitosis. Proc. Natl. Acad. Sci. 95, 12983-12988.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 12983-12988
    • Hsu, L.-C.1    White, R.L.2
  • 32
    • 0024673303 scopus 로고
    • CpG methylation of the cAMP-responsive enhancer/promoter sequence TGAC-GTCA abolishes specific factor binding as well as transcriptional activation
    • Iguchi-Ariga, S.M.M., and Schaffner, W. (1989). CpG methylation of the cAMP-responsive enhancer/promoter sequence TGAC-GTCA abolishes specific factor binding as well as transcriptional activation. Genes & Dev. 3, 612-619.
    • (1989) Genes & Dev. , vol.3 , pp. 612-619
    • Iguchi-Ariga, S.M.M.1    Schaffner, W.2
  • 33
    • 0032583174 scopus 로고    scopus 로고
    • In vitro repression of Brca1-associated RING domain gene 1 (Bard1) induces phenotypic changes in mammary epithelial cells
    • Irminger-Finger, I., Soriano, J.V., Vaudan, G., Montesano, R., and Sappino, A.-P. (1998). In vitro repression of Brca1-associated RING domain gene 1 (Bard1) induces phenotypic changes in mammary epithelial cells. J. Cell Biol. 143, 1329-1339.
    • (1998) J. Cell Biol. , vol.143 , pp. 1329-1339
    • Irminger-Finger, I.1    Soriano, J.V.2    Vaudan, G.3    Montesano, R.4    Sappino, A.-P.5
  • 35
    • 15144342687 scopus 로고    scopus 로고
    • BAP1: A novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
    • Jensen, D.E., Proctor, M., Marquis, S.T., Gardner, H.P., Ha, S.I., Chodosh, L.A. et al. (1998). BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene 16, 1097-1112.
    • (1998) Oncogene , vol.16 , pp. 1097-1112
    • Jensen, D.E.1    Proctor, M.2    Marquis, S.T.3    Gardner, H.P.4    Ha, S.I.5    Chodosh, L.A.6
  • 36
    • 0032007141 scopus 로고    scopus 로고
    • BRCA1-positive patients are small for gestational age compared with their unaffected relatives
    • Jernstrom, H., Johannsson, O., Borg, A., Ivarsson, H., and Olsson, H. (1998). BRCA1-positive patients are small for gestational age compared with their unaffected relatives. Eur. J. Cancer 34, 368-371.
    • (1998) Eur. J. Cancer , vol.34 , pp. 368-371
    • Jernstrom, H.1    Johannsson, O.2    Borg, A.3    Ivarsson, H.4    Olsson, H.5
  • 37
    • 0030667684 scopus 로고    scopus 로고
    • Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in descrete nuclear domains
    • Jin, Y., Xu, X.L., Yang, M-C.W., Wei, F., Ayi, T.-C., Bowcock, A.M., and Baer, R. (1997). Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in descrete nuclear domains. Proc. Natl. Acad. Sci. USA 94, 12075-12080.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 12075-12080
    • Jin, Y.1    Xu, X.L.2    Yang, M.-C.W.3    Wei, F.4    Ayi, T.-C.5    Bowcock, A.M.6    Baer, R.7
  • 39
    • 0030932869 scopus 로고    scopus 로고
    • Cancer-susceptibility genes. Gate keepers and caretakers
    • Kinzler, K.W., and Vogelstein, B. (1997). Cancer-susceptibility genes. Gate keepers and caretakers. Nature 386, 761-763.
    • (1997) Nature , vol.386 , pp. 761-763
    • Kinzler, K.W.1    Vogelstein, B.2
  • 41
    • 0029909565 scopus 로고    scopus 로고
    • A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
    • Lim, D.S., and Hasty, P. (1996). A Mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell. Biol. 16, 7133-7143.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 7133-7143
    • Lim, D.S.1    Hasty, P.2
  • 42
    • 0029784528 scopus 로고    scopus 로고
    • Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
    • Liu, C.-Y., Flesken-Nikitin, A, Li, S., Zeng, Y., and Lee, W.-H. (1996). Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes & Dev. 10, 1835-1843.
    • (1996) Genes & Dev. , vol.10 , pp. 1835-1843
    • Liu, C.-Y.1    Flesken-Nikitin, A.2    Li, S.3    Zeng, Y.4    Lee, W.-H.5
  • 43
    • 0030924656 scopus 로고    scopus 로고
    • Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
    • Ludwig, T., Chapman, D.L., Papaioannou, V.E., and Efstratiadis, A. (1997). Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes and Development 11, 1226-1241.
    • (1997) Genes and Development , vol.11 , pp. 1226-1241
    • Ludwig, T.1    Chapman, D.L.2    Papaioannou, V.E.3    Efstratiadis, A.4
  • 45
    • 0032485196 scopus 로고    scopus 로고
    • CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site
    • Mancini, D.N., Rodenhiser, D.I., Ainsworth, P.J., O'Malley, F.P., Singh, S.M., Xing, W., and Archer, T.K. (1998). CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site. Oncogene 16, 1161-1169.
    • (1998) Oncogene , vol.16 , pp. 1161-1169
    • Mancini, D.N.1    Rodenhiser, D.I.2    Ainsworth, P.J.3    O'Malley, F.P.4    Singh, S.M.5    Xing, W.6    Archer, T.K.7
  • 46
    • 13344262707 scopus 로고    scopus 로고
    • Hereditary breast cancer: Pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage
    • Marcus, J., Watson, P., Page, D.L., Narod, S.A., Lenoir, G.M., Tonin, P. et al. (1996). Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage. Cancer 77, 697-709.
    • (1996) Cancer , vol.77 , pp. 697-709
    • Marcus, J.1    Watson, P.2    Page, D.L.3    Narod, S.A.4    Lenoir, G.M.5    Tonin, P.6
  • 48
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo, A., Herman, J.G., Mao, L., Lee, D.J., Gabrielson, E., Burger, P.C., Baylin, S.B., and Sidransky, O. (1995). 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1, 686-692.
    • (1995) Nat. Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, O.8
  • 50
    • 0030474170 scopus 로고    scopus 로고
    • Evidence for a transcriptional activation function of BRCA1 C-terminal region
    • Monteiro, A.N.A., August, A., and Hanafusa, H. (1996). Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl. Acad. Sci. USA 93, 13595-13599.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13595-13599
    • Monteiro, A.N.A.1    August, A.2    Hanafusa, H.3
  • 51
    • 0032478737 scopus 로고    scopus 로고
    • Interaction of short-range repressors with Drosophila CtBP in the embryo
    • Nibu, Y., Zhang., H., and Levine, M. (1998). Interaction of short-range repressors with Drosophila CtBP in the embryo. Science 280, 101-104.
    • (1998) Science , vol.280 , pp. 101-104
    • Nibu, Y.1    Zhang, H.2    Levine, M.3
  • 52
    • 0027537296 scopus 로고
    • CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene
    • Ohtani-Fujita, N., Fujita, T., Aoike, A., Osifchin, N.E., Robbins, P.D., and Sakai, T. (1992). CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 8, 1063-1067.
    • (1992) Oncogene , vol.8 , pp. 1063-1067
    • Ohtani-Fujita, N.1    Fujita, T.2    Aoike, A.3    Osifchin, N.E.4    Robbins, P.D.5    Sakai, T.6
  • 54
    • 2642611983 scopus 로고    scopus 로고
    • Preferential allelic expression can lead to reduced expression of BRCA1 in sporadic breast cancers
    • Ozcelik, H., To, M.D., Couture, J., Bull, S.B., and Andrulis, I.L. (1998). Preferential allelic expression can lead to reduced expression of BRCA1 in sporadic breast cancers. Int. J. Cancer. 77, 1-6.
    • (1998) Int. J. Cancer. , vol.77 , pp. 1-6
    • Ozcelik, H.1    To, M.D.2    Couture, J.3    Bull, S.B.4    Andrulis, I.L.5
  • 55
    • 0032055490 scopus 로고    scopus 로고
    • Drosophila CtBP: A hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression
    • Poortinga, G., Watanabe, M., and Parkhurst, S.M. (1998). Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and Hairy-mediated transcriptional repression. EMBO J. 17, 2067-2078.
    • (1998) EMBO J. , vol.17 , pp. 2067-2078
    • Poortinga, G.1    Watanabe, M.2    Parkhurst, S.M.3
  • 56
    • 0029822055 scopus 로고    scopus 로고
    • Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells
    • Rajan, J.V., Wang, M., Marquis, S.T., and Chodosh, L.A. (1996). Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. Proc. Natl. Acad. Sci. 93, 13078-13083.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 13078-13083
    • Rajan, J.V.1    Wang, M.2    Marquis, S.T.3    Chodosh, L.A.4
  • 57
    • 0030059385 scopus 로고    scopus 로고
    • Antisense RNA to the putative tumor suppressor BRCA1 transforms mouse fibroblasts
    • Rao, V.N., Shao, N., Ahmad, M., Shyam, E., and Reddy, P. (1996). Antisense RNA to the putative tumor suppressor BRCA1 transforms mouse fibroblasts. Oncogene 12, 523-528.
    • (1996) Oncogene , vol.12 , pp. 523-528
    • Rao, V.N.1    Shao, N.2    Ahmad, M.3    Shyam, E.4    Reddy, P.5
  • 59
    • 0029666432 scopus 로고    scopus 로고
    • Heterogeneous point mutations in the BRCA1 breast cancer susceptibility gene occur in high frequency at the site of homonuclotide tracts, short repeats and methylatable CpG/CpNpG motifs
    • Rodenhiser, D.I., Chakraborty, P., Andrews, J., Ainsworth, P., Mancini, D., Lopes, E., and Singh, S. (1996). Heterogeneous point mutations in the BRCA1 breast cancer susceptibility gene occur in high frequency at the site of homonuclotide tracts, short repeats and methylatable CpG/CpNpG motifs. Oncogene 12, 2623-2629.
    • (1996) Oncogene , vol.12 , pp. 2623-2629
    • Rodenhiser, D.I.1    Chakraborty, P.2    Andrews, J.3    Ainsworth, P.4    Mancini, D.5    Lopes, E.6    Singh, S.7
  • 62
    • 0030850047 scopus 로고    scopus 로고
    • Dynamic changes of BRCA1 subnuclear location and phosphorylation state are inititated by DNA damage
    • Scully, R., Chen, J., Ochs, R.L., Keegan, K., Hoekstra, M., Feunteun, J., and Livingston, D.M. (1997b). Dynamic changes of BRCA1 subnuclear location and phosphorylation state are inititated by DNA damage. Cell 90, 425-235.
    • (1997) Cell , vol.90 , pp. 425-1235
    • Scully, R.1    Chen, J.2    Ochs, R.L.3    Keegan, K.4    Hoekstra, M.5    Feunteun, J.6    Livingston, D.M.7
  • 64
    • 0029948779 scopus 로고    scopus 로고
    • Induction of apoptosis by the tumor suppressor protein BRCA1
    • Shao, N., Chai, Y.L., Shyam, E., Reddy, P., and Rao, V.N. (1996). Induction of apoptosis by the tumor suppressor protein BRCA1. Oncogene 13, 1-7.
    • (1996) Oncogene , vol.13 , pp. 1-7
    • Shao, N.1    Chai, Y.L.2    Shyam, E.3    Reddy, P.4    Rao, V.N.5
  • 66
    • 0031105256 scopus 로고    scopus 로고
    • The role of DNA repair in development
    • Snow, E.T. (1997). The role of DNA repair in development. Reprod. Toxicol. 11, 353-365.
    • (1997) Reprod. Toxicol. , vol.11 , pp. 353-365
    • Snow, E.T.1
  • 67
    • 8944260900 scopus 로고    scopus 로고
    • Truncation at conserved terminal regions of BRCA1 protein is associated with highly proliferating hereditary breast cancers
    • Sobol, H., Stoppa-Lyonnet, D., Bressac-de-Paillerets, B., Peyrat, J.-P., Keranguseven, F., Janin, N. et al. (1996). Truncation at conserved terminal regions of BRCA1 protein is associated with highly proliferating hereditary breast cancers. Can. Res. 56, 3216-3219.
    • (1996) Can. Res. , vol.56 , pp. 3216-3219
    • Sobol, H.1    Stoppa-Lyonnet, D.2    Bressac-De-Paillerets, B.3    Peyrat, J.-P.4    Keranguseven, F.5    Janin, N.6
  • 69
    • 0028919917 scopus 로고
    • Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells
    • Soriano, J.V., Pepper, M.S., Nakamura, T., Orci, L., and Montesano, R. (1995). Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. J. Cell. Sci. 108, 413-30.
    • (1995) J. Cell. Sci. , vol.108 , pp. 413-430
    • Soriano, J.V.1    Pepper, M.S.2    Nakamura, T.3    Orci, L.4    Montesano, R.5
  • 70
    • 0032492549 scopus 로고    scopus 로고
    • Decreased BRCA1 expression levels may arrest the cell cycle through activation of p53 checkpoint in human sporadic breast tumors
    • Sourvinos, G., and Spandidos, D.A. (1998). Decreased BRCA1 expression levels may arrest the cell cycle through activation of p53 checkpoint in human sporadic breast tumors. Biochem. Biophys. Res. Com. 245, 75-80.
    • (1998) Biochem. Biophys. Res. Com. , vol.245 , pp. 75-80
    • Sourvinos, G.1    Spandidos, D.A.2
  • 72
    • 0029083814 scopus 로고
    • The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percentin Ashkenazi Jewish individuals
    • Struewing, J.P., Abeliovich, D., Peretz, T., Avishar, N., Kaback, M.M., Collins, F., and Brody, L.C. (1995). The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percentin Ashkenazi Jewish individuals. Nature Genet. 11, 198-200.
    • (1995) Nature Genet. , vol.11 , pp. 198-200
    • Struewing, J.P.1    Abeliovich, D.2    Peretz, T.3    Avishar, N.4    Kaback, M.M.5    Collins, F.6    Brody, L.C.7
  • 73
    • 14444277477 scopus 로고    scopus 로고
    • Brca2 is required for embryonic cellular proliferation in the mouse
    • Suzuki, A., de la Pompa, J.L., Hakem, R., Elia, A., Yoshida, R., Mo, R., et al. (1997). Brca2 is required for embryonic cellular proliferation in the mouse. Genes & Dev. 11, 1242-1252.
    • (1997) Genes & Dev. , vol.11 , pp. 1242-1252
    • Suzuki, A.1    De La Pompa, J.L.2    Hakem, R.3    Elia, A.4    Yoshida, R.5    Mo, R.6
  • 74
    • 0032557650 scopus 로고    scopus 로고
    • Staurosporine-sensitive protein phosphorylation is required for postreplication DNA repair in human cells
    • Svetlova, M.P., Solovjeva, L.V., Nikiforov, A.A., Chagin, V.A., Lehmann, A.R., and Tomilin, N.V. (1998). Staurosporine-sensitive protein phosphorylation is required for postreplication DNA repair in human cells. FEBS Letters 428, 23-26.
    • (1998) FEBS Letters , vol.428 , pp. 23-26
    • Svetlova, M.P.1    Solovjeva, L.V.2    Nikiforov, A.A.3    Chagin, V.A.4    Lehmann, A.R.5    Tomilin, N.V.6
  • 75
    • 0028950999 scopus 로고
    • Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
    • Thompson, M.E., Jensen, R.A., Obermiller, P.S., Page, D.L., and Holt, J.T. (1995). Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat. Genet. 9, 444-450.
    • (1995) Nat. Genet. , vol.9 , pp. 444-450
    • Thompson, M.E.1    Jensen, R.A.2    Obermiller, P.S.3    Page, D.L.4    Holt, J.T.5
  • 76
    • 0030894785 scopus 로고    scopus 로고
    • Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germline mutations
    • Tirkkonen, M., Johannsson, O., Agnarsson, B.A., Olsson, H., Ingvarsson, S., Karhuy, R. et al. (1997). Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germline mutations. Cancer Res. 57, 1222-1227.
    • (1997) Cancer Res. , vol.57 , pp. 1222-1227
    • Tirkkonen, M.1    Johannsson, O.2    Agnarsson, B.A.3    Olsson, H.4    Ingvarsson, S.5    Karhuy, R.6
  • 77
    • 0029821929 scopus 로고    scopus 로고
    • Requirement of proliferating cell nuclear antigen in RAD6-dependent postreplicational DNA repair
    • Torres-Ramos, C.A., Yoder, B.L., Burgers, P.M.J., Prakash, S., and Prakash, L. (1996). Requirement of proliferating cell nuclear antigen in RAD6-dependent postreplicational DNA repair. Proc. Natl. Acad. Sci. USA 93, 9676-9681.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9676-9681
    • Torres-Ramos, C.A.1    Yoder, B.L.2    Burgers, P.M.J.3    Prakash, S.4    Prakash, L.5
  • 79
    • 10244246652 scopus 로고    scopus 로고
    • BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells
    • Vaughn, J.P., Davis, P.L., Jarboe, M.D., Huper, G., Evans, A.C., Wiseman, R. W. et al. (1996). BRCA1 Expression is induced before DNA synthesis in both normal and tumor-derived breast cells. Cell Growth Diff. 7, 711-715.
    • (1996) Cell Growth Diff. , vol.7 , pp. 711-715
    • Vaughn, J.P.1    Davis, P.L.2    Jarboe, M.D.3    Huper, G.4    Evans, A.C.5    Wiseman, R.W.6
  • 80
    • 0031840528 scopus 로고    scopus 로고
    • Pathology of sporadic breast tumors with LOH at the BRCA1 locus: Correlation with histopathological features specific to familial BRCA1 tumors and absence of microsatellite instability
    • Vaurs-Barriere, C., Vidal, V., Penault-Llorca, F., Kwiatkowski, F., Maugard, C., and Bignon, Y. (1998). Pathology of sporadic breast tumors with LOH at the BRCA1 locus: correlation with histopathological features specific to familial BRCA1 tumors and absence of microsatellite instability. Int. J. Oncol. 12, 1373-1378.
    • (1998) Int. J. Oncol. , vol.12 , pp. 1373-1378
    • Vaurs-Barriere, C.1    Vidal, V.2    Penault-Llorca, F.3    Kwiatkowski, F.4    Maugard, C.5    Bignon, Y.6
  • 81
    • 0030838793 scopus 로고    scopus 로고
    • BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases
    • Wang, H., Shao, N., Ding, Q.M., Cui, J-q., Reddy, E.S.P., and Rao, V.N. (1997). BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. Oncogene 15, 143-157.
    • (1997) Oncogene , vol.15 , pp. 143-157
    • Wang, H.1    Shao, N.2    Ding, Q.M.3    Cui, J.-Q.4    Reddy, E.S.P.5    Rao, V.N.6
  • 82
    • 0032532543 scopus 로고    scopus 로고
    • BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells
    • Wang, Q., Zhang, H., Kajino, K., and Greene, M.I. (1998). BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene 17, 1939-1948.
    • (1998) Oncogene , vol.17 , pp. 1939-1948
    • Wang, Q.1    Zhang, H.2    Kajino, K.3    Greene, M.I.4
  • 85
    • 0030761231 scopus 로고    scopus 로고
    • Complex regulation of the BRCA1 gene
    • Xu, C-F., Chambers, J.A., and Solomon, E. (1997). Complex regulation of the BRCA1 gene. J. Biol. Chem. 272, 20994-20997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 20994-20997
    • Xu, C.-F.1    Chambers, J.A.2    Solomon, E.3
  • 86
    • 0032566753 scopus 로고    scopus 로고
    • The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
    • Yu, X., Wu, L.C., Bowcock, A.M., Aronheim, A., and Baer, R. (1998). The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. J. Biol. Chem. 273, 25388-25392.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25388-25392
    • Yu, X.1    Wu, L.C.2    Bowcock, A.M.3    Aronheim, A.4    Baer, R.5
  • 88
    • 0032476599 scopus 로고    scopus 로고
    • Structure of an XRCC1 BRCT domain: A new protein-protein interaction molecule
    • Zhang, X., Morera, S., Bates, P.A., Whitehead, P.C., Coffer, A.I., Hainbucher, K. et al. (1998). Structure of an XRCC1 BRCT domain: a new protein-protein interaction molecule. EMBO J. 17, 6404-6411.
    • (1998) EMBO J. , vol.17 , pp. 6404-6411
    • Zhang, X.1    Morera, S.2    Bates, P.A.3    Whitehead, P.C.4    Coffer, A.I.5    Hainbucher, K.6


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