Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E. coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine

Carcinogenesis

Volumn 20, Issue 1, 1999, Pages 103-108

  Edara, Suvarchala ^a   Kanugula, Sreenivas ^a   Pegg, Anthony E ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ADENINE; CYSTEINE; GUANINE; METHYLNITRONITROSOGUANIDINE; NUCLEOTIDE BINDING PROTEIN; THYMINE;

ARTICLE; CELL KILLING; CONTROLLED STUDY; DNA BINDING; ESCHERICHIA COLI; EXCISION REPAIR; GENE EXPRESSION; GENE MUTATION; METHYLATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; TOXICITY;

AMINO ACID SUBSTITUTION; CODON; DNA DAMAGE; DNA REPAIR; ESCHERICHIA COLI; GUANINE; HUMANS; METHYLNITRONITROSOGUANIDINE; MUTAGENESIS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POINT MUTATION; RECOMBINANT FUSION PROTEINS; THYMIDINE;

EID: 0032922238     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.1.103     Document Type: Article

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