Polymerase blockage and misincorporation of dNTPs opposite the ethylene dibromide-derived DNA adducts S-[2-(N7-Guanyl)ethyl]glutathione, S-[2-(N2- Guanyl)ethyl]glutathione, and S-[2-(O6-Guanyl)ethyl]glutathione

Chemical Research in Toxicology

Volumn 11, Issue 4, 1998, Pages 311-316

  Kim, Mi Sook ^a,b   Peter Guengerich, F ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIBROMOETHANE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; DNA POLYMERASE; GLUTATHIONE DERIVATIVE; NUCLEOSIDE TRIPHOSPHATE; PRIMER DNA; RNA DIRECTED DNA POLYMERASE; THYMIDINE TRIPHOSPHATE;

ARTICLE; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; DNA ADDUCT; DNA REPLICATION; GENE INSERTION; MUTAGENICITY; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; STEADY STATE; TOXIN ANALYSIS;

DNA; DNA ADDUCTS; DNA-DIRECTED DNA POLYMERASE; ETHYLENE DIBROMIDE; GLUTATHIONE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 2642611090     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx970206m     Document Type: Article

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