O6-Benzylguanine: A clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair

Cancer Research

Volumn 59, Issue 10, 1999, Pages 2402-2410

  Spiro, Timothy P ^a,b,c,f   Gerson, Stanton L ^a,c   Liu, Lili ^a   Majka, Susan ^c   Haaga, John ^a,c,d   Hoppel, Charles L ^b,c,f   Ingalls, Stephen T ^b,c,f   Pluda, James M ^e   Willson, James K V ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c Ireland Cancer Center   (United States)

^d UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f Louis Stokes Cleveland DVAMC Psychiatry Service   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O BENZYLGUANINE; ANTINEOPLASTIC AGENT; CARMUSTINE; NITROSOUREA DERIVATIVE; TRANSFERASE; 8 OXO O(6) BENZYLGUANINE; 8-OXO-O(6)-BENZYLGUANINE; ALKYLATING AGENT; DNA; DRUG DERIVATIVE; GUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; O(6) BENZYLGUANINE; O(6)-BENZYLGUANINE; PRODRUG; TUMOR PROTEIN;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA REPAIR; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MALE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; TUMOR BIOPSY; BIOPSY; BIOSYNTHESIS; BIOTRANSFORMATION; BLOOD; BREAST TUMOR; COMPUTER ASSISTED TOMOGRAPHY; DIGESTIVE SYSTEM TUMOR; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; LUNG TUMOR; METABOLISM; MIDDLE AGED; NEOPLASM; PATHOLOGY; SAFETY;

ADULT; AGED; ANTINEOPLASTIC AGENTS, ALKYLATING; BIOPSY; BIOTRANSFORMATION; BREAST NEOPLASMS; CARMUSTINE; DIGESTIVE SYSTEM NEOPLASMS; DNA REPAIR; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; FEMALE; GUANINE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASMS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PRODRUGS; SAFETY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0033561807     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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