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Volumn 12, Issue 6, 1999, Pages 544-551

Mammalian cells expressing Escherichia coli O6-alkylguanine-DNA alkyltransferases are hypersensitive to dibromoalkanes

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIBROMOETHANE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; DIBROMOALKANE DERIVATIVE; DIBROMOMETHANE; UNCLASSIFIED DRUG;

EID: 0032979605     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx980250h     Document Type: Article
Times cited : (23)

References (61)
  • 1
    • 0022850953 scopus 로고
    • Some halogenated hydrocarbons and pesticide exposure
    • International Agency for Research on Cancer (1986) Some halogenated hydrocarbons and pesticide exposure. IARC Monogr. Eval. Carcinog. Risk Chem. Man 41, 1-407.
    • (1986) IARC Monogr. Eval. Carcinog. Risk Chem. Man , vol.41 , pp. 1-407
  • 2
    • 0023493097 scopus 로고
    • Overall evaluations of carcinogenicity: An updating of IARC monographs volumes 1 to 42
    • International Agency for Research on Cancer (1987) Overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1 to 42. IARC Monogr. Eval. Carcinog. Risk Chem. Man 7 (Suppl.), 1-440.
    • (1987) IARC Monogr. Eval. Carcinog. Risk Chem. Man , vol.7 , Issue.SUPPL. , pp. 1-440
  • 4
    • 0030707567 scopus 로고    scopus 로고
    • An update of the National Toxicology Program database on nasal carcinogens
    • Haseman, J. K., and Hailey, J. R. (1997) An update of the National Toxicology Program database on nasal carcinogens. Mutat. Res. 380, 3-11.
    • (1997) Mutat. Res. , vol.380 , pp. 3-11
    • Haseman, J.K.1    Hailey, J.R.2
  • 5
    • 0030949982 scopus 로고    scopus 로고
    • Effect of decreased glutathione levels in hereditary glutathione synthetase deficiency on dibromoethaneinduced genotoxicity in human fibroblasts
    • DeLeve, L. D. (1997) Effect of decreased glutathione levels in hereditary glutathione synthetase deficiency on dibromoethaneinduced genotoxicity in human fibroblasts. Mutat. Res. 389, 291297.
    • (1997) Mutat. Res. , vol.389 , pp. 291297
    • DeLeve, L.D.1
  • 6
    • 0031951527 scopus 로고    scopus 로고
    • A rapid, sensitive method for the quantitation of iV-acetyl-S-(2-hydroxyethyl)-L-cysteine in human urine using isotope-dilution HPLC-MS-MS
    • Barr, D. B., and Ashley, D. L. (1998) A rapid, sensitive method for the quantitation of iV-acetyl-S-(2-hydroxyethyl)-L-cysteine in human urine using isotope-dilution HPLC-MS-MS. J. Anal. Toxicol. 2, 96-104.
    • (1998) J. Anal. Toxicol. , vol.2 , pp. 96-104
    • Barr, D.B.1    Ashley, D.L.2
  • 7
    • 0031925944 scopus 로고    scopus 로고
    • In vitro assessment of the effect of halogenated hydrocarbons: Chloroform, dichloromethane, and dibromoethane on embryonic development of the rat
    • Brown-Woodman, P. D., Hayes, L. C., Huq, F., Herlihy, C., Picker, K., and Webster, W. S. (1998) In vitro assessment of the effect of halogenated hydrocarbons: chloroform, dichloromethane, and dibromoethane on embryonic development of the rat. Teratology 57, 321-333.
    • (1998) Teratology , vol.57 , pp. 321-333
    • Brown-Woodman, P.D.1    Hayes, L.C.2    Huq, F.3    Herlihy, C.4    Picker, K.5    Webster, W.S.6
  • 8
    • 0001406666 scopus 로고
    • Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals
    • McCann, J. E., Choi, E., Yamasaki, E., and Ames, B. N. (1975) Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proc. Natl. Acad. Sei. U.S.A. 72, 5135-5139.
    • (1975) Proc. Natl. Acad. Sei. U.S.A. , vol.72 , pp. 5135-5139
    • McCann, J.E.1    Choi, E.2    Yamasaki, E.3    Ames, B.N.4
  • 9
    • 0028987529 scopus 로고
    • Ogt Alkyltransferase enhances' dibromaolkane mutagenicity in excision repair-deficient Escherichia coli K-12
    • Abril, N., Luque-Romero, F. L., Prieto-Alamo, M. J., Margison, G. P., and Pueyo, C. (1995) Ogt Alkyltransferase enhances' dibromaolkane mutagenicity in excision repair-deficient Escherichia coli K-12. Mol. Carcinog. 12, 110-117.
    • (1995) Mol. Carcinog. , vol.12 , pp. 110-117
    • Abril, N.1    Luque-Romero, F.L.2    Prieto-Alamo, M.J.3    Margison, G.P.4    Pueyo, C.5
  • 10
    • 0029760025 scopus 로고    scopus 로고
    • Contribution of ogt-encoded alkyltransferase to resistance to chloroethylnitrosoureas in nucleotide excision repair-deficient Escherichia coli
    • Abril, N., Ferrezuelo, F., Prieto-Alamo, M. J., Rafferty, J. A., Margison, G. P., and Pueyo, C. (1996) Contribution of ogt-encoded alkyltransferase to resistance to chloroethylnitrosoureas in nucleotide excision repair-deficient Escherichia coli. Carcinogenesis 17, 1609-1614.
    • (1996) Carcinogenesis , vol.17 , pp. 1609-1614
    • Abril, N.1    Ferrezuelo, F.2    Prieto-Alamo, M.J.3    Rafferty, J.A.4    Margison, G.P.5    Pueyo, C.6
  • 11
    • 0031408141 scopus 로고    scopus 로고
    • Bacterial and mammalian DNA-alkyltransferases sensitise Escherichia coli to the lethal and mutagenic effects of dibromoalkanes
    • Abril, N., Luque-Romero, F. L., Prieto-Alamo, M. J., Margison, G. P., Rafferty, J. A., and Pueyo, C. (1997) Bacterial and mammalian DNA-alkyltransferases sensitise Escherichia coli to the lethal and mutagenic effects of dibromoalkanes. Carcinogenesis 10, 1883-1888.
    • (1997) Carcinogenesis , vol.10 , pp. 1883-1888
    • Abril, N.1    Luque-Romero, F.L.2    Prieto-Alamo, M.J.3    Margison, G.P.4    Rafferty, J.A.5    Pueyo, C.6
  • 13
    • 0030070661 scopus 로고    scopus 로고
    • Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004
    • Shimada, T., Yamazaki, H., Oda, Y., Hiratsuka, A., Watabe, T., and Guengerich, F. P. (1996) Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004. Chem. Res. Toxicol. 9, 333-340.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 333-340
    • Shimada, T.1    Yamazaki, H.2    Oda, Y.3    Hiratsuka, A.4    Watabe, T.5    Guengerich, F.P.6
  • 14
    • 0029947171 scopus 로고    scopus 로고
    • Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium
    • Their, R., Pemble, S. E., Kramer, H., Taylor, J. B., Guengerich, F. P., and Ketterer, B. (1996) Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium. Carcinogenesis 17, 163-166.
    • (1996) Carcinogenesis , vol.17 , pp. 163-166
    • Their, R.1    Pemble, S.E.2    Kramer, H.3    Taylor, J.B.4    Guengerich, F.P.5    Ketterer, B.6
  • 15
    • 0028003312 scopus 로고
    • Mutation spectra of 1,2-dibromoethane, 1,2-dichloroethane and 1-bromo-2-chloroethane in excision repair proficient and repair deficient strains ofDrosophila melanogaster
    • Ballering, L. A., Nivard, M. J. M., and Vogel, E. W. (1994) Mutation spectra of 1,2-dibromoethane, 1,2-dichloroethane and 1-bromo-2-chloroethane in excision repair proficient and repair deficient strains ofDrosophila melanogaster. Carcinogenesis 15, 869-875.
    • (1994) Carcinogenesis , vol.15 , pp. 869-875
    • Ballering, L.A.1    Nivard, M.J.M.2    Vogel, E.W.3
  • 16
    • 0031982686 scopus 로고    scopus 로고
    • Strand-specific mutation induction by 1,2-dibromomethane at the hypoxanthine-guanine phosphoribosyltransferase locus of Chinese hamster ovary cells
    • Ballering, L. A., Vogel, E. W., Vrieling, H., and Nivard, M. J. (1998) Strand-specific mutation induction by 1,2-dibromomethane at the hypoxanthine-guanine phosphoribosyltransferase locus of Chinese hamster ovary cells. Mutagenesis 13, 61-65.
    • (1998) Mutagenesis , vol.13 , pp. 61-65
    • Ballering, L.A.1    Vogel, E.W.2    Vrieling, H.3    Nivard, M.J.4
  • 17
    • 0027397660 scopus 로고
    • Molecular mechanisms of dibromoalkane cytotoxicity in isolated rat hepatocytes
    • Khan, S., Sood, C., and O'Brien, P. J. (1993) Molecular mechanisms of dibromoalkane cytotoxicity in isolated rat hepatocytes. Blochem. Pharmacol. 45, 439-447.
    • (1993) Blochem. Pharmacol. , vol.45 , pp. 439-447
    • Khan, S.1    Sood, C.2    O'Brien, P.J.3
  • 18
    • 0029964511 scopus 로고    scopus 로고
    • DNA sequence analysis of methylene chloride-induced HPRT mutations in Chinese hamster ovary cells: Comparison with the mutation spectrum obtained for 1,2-dibromoethane and formaldehyde
    • Graves, R. J., Trueman, P., and Jones, S. (1996) DNA sequence analysis of methylene chloride-induced HPRT mutations in Chinese hamster ovary cells: comparison with the mutation spectrum obtained for 1,2-dibromoethane and formaldehyde. Mutagenesis 11, 229-233.
    • (1996) Mutagenesis , vol.11 , pp. 229-233
    • Graves, R.J.1    Trueman, P.2    Jones, S.3
  • 19
    • 0030010272 scopus 로고    scopus 로고
    • Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay
    • Graves, R. J., and Green, T. (1996) Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay. Mutat. Res. 367, 143-150.
    • (1996) Mutat. Res. , vol.367 , pp. 143-150
    • Graves, R.J.1    Green, T.2
  • 20
    • 0019411274 scopus 로고
    • Metabolic activation of 1,2dibromoethane by glutathione transferase and by microsomal mixed function oxidase: Further evidence for formation of two reactive metabolites
    • Shih, T. W., and Hill, D. L. (1981) Metabolic activation of 1,2dibromoethane by glutathione transferase and by microsomal mixed function oxidase: further evidence for formation of two reactive metabolites. Res. Commun. Chem. Pathol. Pharmacol. 33, 449-461.
    • (1981) Res. Commun. Chem. Pathol. Pharmacol. , vol.33 , pp. 449-461
    • Shih, T.W.1    Hill, D.L.2
  • 21
    • 0019404603 scopus 로고
    • The metabolic formation of JV-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-l,2-dibromoethane. Relative importance of oxidation and glutathione conjugation in vivo
    • van Bladeren, P. J., Breimer, D. D., van Huijgenvoort, J. A. T. C. M., Vermeulen, N. P. E., and van der Gen, A. (1981) The metabolic formation of JV-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-l,2-dibromoethane. Relative importance of oxidation and glutathione conjugation in vivo. Biochem. Pharmacol. 30,24992502.
    • (1981) Biochem. Pharmacol. , vol.30 , pp. 24992502
    • Van Bladeren, P.J.1    Breimer, D.D.2    Van Huijgenvoort, J.A.T.C.M.3    Vermeulen, N.P.E.4    Van Der Gen, A.5
  • 25
    • 0028710726 scopus 로고
    • Dihaloalkanes and polyhaloalkenes
    • Hemminki, K., Dipple, A., Shuker, D. E. G., Kadlubar, F. F., Segerback, D., and Bartsch, H., Eds. IARC Scientific Publication 125, IARC, Lyon, France
    • Guengerich, F. P., Min, K.-S., Persmark, M., Kim, M. S., Humphreys, W. G., Cmarik, J. M., and Thier, R. (1994) Dihaloalkanes and polyhaloalkenes. In DNA Adducts, Identification and Biological Significance (Hemminki, K., Dipple, A., Shuker, D. E. G., Kadlubar, F. F., Segerback, D., and Bartsch, H., Eds.) pp 57-72, IARC Scientific Publication 125, IARC, Lyon, France.
    • (1994) DNA Adducts, Identification and Biological Significance , pp. 57-72
    • Guengerich, F.P.1    Min, K.-S.2    Persmark, M.3    Kim, M.S.4    Humphreys, W.G.5    Cmarik, J.M.6    Thier, R.7
  • 26
    • 0008252723 scopus 로고
    • Evidence for the formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA
    • Ozawa, N., and Guengerich, F. P. (1983) Evidence for the formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA. Proc. Natl. Acad. Sei. U.S.A. 80, 5266-5270.
    • (1983) Proc. Natl. Acad. Sei. U.S.A. , vol.80 , pp. 5266-5270
    • Ozawa, N.1    Guengerich, F.P.2
  • 27
    • 0022559064 scopus 로고
    • S-[2-(N7-Guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane
    • Koga, N., Inskeep, P. B., Harris, T. H., and Guengerieh, F. P. (1986) S-[2-(N7-Guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane. Biochemistry 25, 2192-2198.
    • (1986) Biochemistry , vol.25 , pp. 2192-2198
    • Koga, N.1    Inskeep, P.B.2    Harris, T.H.3    Guengerieh, F.P.4
  • 28
    • 0026657542 scopus 로고
    • Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mpl8 DNA with S-(2-chlorethyl)glutathione. Evidence for a role of S-[2-N7-guanyl(ethyl)]glutathione as a mutagenic lesion formed from ethylene dibromide
    • Cmarik, J. L., Humphreys, W. G., Brunner, K. L., Lloyds, R. S., Tibbetts, C., and Guengerich, F. P. (1992) Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mpl8 DNA with S-(2-chlorethyl)glutathione. Evidence for a role of S-[2-N7-guanyl(ethyl)]glutathione as a mutagenic lesion formed from ethylene dibromide. J. Biol. Chem. 267, 6672-6679.
    • (1992) J. Biol. Chem. , vol.267 , pp. 6672-6679
    • Cmarik, J.L.1    Humphreys, W.G.2    Brunner, K.L.3    Lloyds, R.S.4    Tibbetts, C.5    Guengerich, F.P.6
  • 29
    • 0030770458 scopus 로고    scopus 로고
    • 2-guanyl)ethyl]glutathione, and S-[2-(O5-guanyl)ethyl]glutathione at a single site
    • 2-guanyl)ethyl]glutathione, and S-[2-(O5-guanyl)ethyl]glutathione at a single site. Chem. Res. Toxicol. 10, 1133-1143.
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 1133-1143
    • Kim, M.S.1    Guengerich, F.P.2
  • 31
    • 0022960054 scopus 로고
    • Neutral reactions of haloacetaldehydes with polynucleotides: Mechanisms, monomer and polymer products
    • Singer, B., Holbrook, S. R., Fraenkel-Conrat, H., and Kusmierek, J. T. (1986) Neutral reactions of haloacetaldehydes with polynucleotides: mechanisms, monomer and polymer products. IARC Sei. Publ. 70, 45-56.
    • (1986) IARC Sei. Publ. , vol.70 , pp. 45-56
    • Singer, B.1    Holbrook, S.R.2    Fraenkel-Conrat, H.3    Kusmierek, J.T.4
  • 32
    • 0026616794 scopus 로고
    • 1,N2-ethenodeoxyguanosine: Properties and formation in chloroacetaldehyde-treated polynucleotides and DNA
    • Kusmierek, J. T., and Singer, B. (1992) 1,N2-ethenodeoxyguanosine: properties and formation in chloroacetaldehyde-treated polynucleotides and DNA. Chem. Res. Toxicol. 5, 634-638.
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 634-638
    • Kusmierek, J.T.1    Singer, B.2
  • 33
    • 0016796470 scopus 로고
    • Metabolism of dihalomethanes to carbon monoxide. II. in vitro studies
    • Kubic, V. L., and Anders, M. W. (1975) Metabolism of dihalomethanes to carbon monoxide. II. In vitro studies. Drug Metab. Dispos. 3, 104-112.
    • (1975) Drug Metab. Dispos. , vol.3 , pp. 104-112
    • Kubic, V.L.1    Anders, M.W.2
  • 35
    • 0019563951 scopus 로고
    • Some antineoplastic and Immunosupressive Agents
    • International Agency for Research on Cancer (1981) Some antineoplastic and Immunosupressive Agents. IARC Monogr. Eval. Carcinog. Risk Chem. Man 26, 79-95.
    • (1981) IARC Monogr. Eval. Carcinog. Risk Chem. Man , vol.26 , pp. 79-95
  • 37
    • 0000017747 scopus 로고
    • Biological consequences of reactions with DNA; role of specific lesions
    • Grover, P. L., and Phillips, D. H., Eds. Springer, Heidelberg, Germany
    • Margison, G. P., and O'Connor, P. J. (1990) Biological consequences of reactions with DNA; role of specific lesions. In Chemical Carcinogenesis and Mutagenesis. Handbook of Experimental Pharmacology (Grover, P. L., and Phillips, D. H., Eds.) Vol 94/1, pp 547-571, Springer, Heidelberg, Germany.
    • (1990) Chemical Carcinogenesis and Mutagenesis. Handbook of Experimental Pharmacology , vol.94 , Issue.1 , pp. 547-571
    • Margison, G.P.1    O'Connor, P.J.2
  • 38
    • 0025195404 scopus 로고
    • 6-alkylguanine-DNA-aIkyltransferase; regulation and importance in response to alkylating carcinogenic and therapeutic agents
    • 6-alkylguanine-DNA-aIkyltransferase; regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res. 50, 6119-6129.
    • (1990) Cancer Res. , vol.50 , pp. 6119-6129
    • Pegg, A.E.1
  • 40
    • 0026584519 scopus 로고
    • Leukemias and myeloplastic syndromes secondary to drug, radiation and environmental exposure
    • Levine, E. G., and Bloomfield, C. D. (1992) Leukemias and myeloplastic syndromes secondary to drug, radiation and environmental exposure. Semin. Oncol. 19, 47-84.
    • (1992) Semin. Oncol. , vol.19 , pp. 47-84
    • Levine, E.G.1    Bloomfield, C.D.2
  • 41
    • 0027395616 scopus 로고
    • Molecular epidemiology of therapy-related leukemias
    • Gerson, S. L. (1993) Molecular epidemiology of therapy-related leukemias. Curr. Opin. Oncol. 5, 136-144.
    • (1993) Curr. Opin. Oncol. , vol.5 , pp. 136-144
    • Gerson, S.L.1
  • 42
    • 0025155274 scopus 로고
    • Leukaemia complicating treatment for Hodgkin's disease: The experience of the British National Lymphoma Investigation
    • Devereux, S., Selassie, T. G., Vaughan-Hudson, G., VaughanHudson, B., and Linch, D. C. (1990) Leukaemia complicating treatment for Hodgkin's disease: the experience of the British National Lymphoma Investigation. Br. Med. J. 301, 1077-1080.
    • (1990) Br. Med. J. , vol.301 , pp. 1077-1080
    • Devereux, S.1    Selassie, T.G.2    Vaughan-Hudson, G.3    Vaughanhudson, B.4    Linch, D.C.5
  • 43
    • 0022431993 scopus 로고
    • 6-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay
    • 6-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay. Nucleic Acids Res. 13, 1939-1952.
    • (1985) Nucleic Acids Res. , vol.13 , pp. 1939-1952
    • Margison, G.P.1    Cooper, D.P.2    Brennand, J.3
  • 44
    • 0020565479 scopus 로고
    • Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli
    • Sedgwick, B. (1983) Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli. Mol. Gen. Genet. 191, 466-472.
    • (1983) Mol. Gen. Genet. , vol.191 , pp. 466-472
    • Sedgwick, B.1
  • 46
    • 0028533694 scopus 로고
    • DNA damage tolerance, mismatch repair and genome instability
    • Karran, P., and Bignami, M. (1994) DNA damage tolerance, mismatch repair and genome instability. BioEssays 16,833-839.
    • (1994) BioEssays , vol.16 , pp. 833-839
    • Karran, P.1    Bignami, M.2
  • 47
    • 0019126210 scopus 로고
    • DNA-crosslinking and monoadduct repair in nitrosourea treated tumor cells
    • Erickson, L. C., Laurent, G., Sharkey, N. A., and Kohn, K W. (1980) DNA-crosslinking and monoadduct repair in nitrosourea treated tumor cells. Nature 288, 727-729.
    • (1980) Nature , vol.288 , pp. 727-729
    • Erickson, L.C.1    Laurent, G.2    Sharkey, N.A.3    Kohn, K.W.4
  • 49
    • 0025116511 scopus 로고
    • DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal
    • Ludlum, D. B. (1990) DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal. Mutat. Res. 233, 117-126.
    • (1990) Mutat. Res. , vol.233 , pp. 117-126
    • Ludlum, D.B.1
  • 50
    • 0022989218 scopus 로고
    • 6 alkylguanine-DNA alkyltransferase reduces the toxic effects of alkylating agents
    • 6 alkylguanine-DNA alkyltransferase reduces the toxic effects of alkylating agents. Carcinogenesis 7, 2081-2084.
    • (1986) Carcinogenesis , vol.7 , pp. 2081-2084
    • Brennand, J.1    Margison, G.P.2
  • 51
    • 0023001905 scopus 로고
    • Reduction of the toxicity and mutagenicicty of alkylating agents in mammalian cells harbouring the Escherichia coli alkyltransferase gene
    • Brennand, J., and Margison, G. P. (1986) Reduction of the toxicity and mutagenicicty of alkylating agents in mammalian cells harbouring the Escherichia coli alkyltransferase gene. Proc. Natl. Acad. Sci. U.S.A. 83, 6292-6296.
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 6292-6296
    • Brennand, J.1    Margison, G.P.2
  • 52
    • 0023087676 scopus 로고
    • Functional expression of the E. coli alkyltransferase gene in mammalian cells
    • Margison, G. P., and Brennand, J. (1987) Functional expression of the E. coli alkyltransferase gene in mammalian cells. J. Cell Sei. 6 (Suppl., 83-96.
    • (1987) J. Cell Sei. , vol.6 , Issue.SUPPL. , pp. 83-96
    • Margison, G.P.1    Brennand, J.2
  • 53
    • 0027194117 scopus 로고
    • 6-alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas
    • 6-alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas. Br. J. Cancer 67, 1196-1202.
    • (1993) Br. J. Cancer , vol.67 , pp. 1196-1202
    • Harris, L.C.1    Margison, G.P.2
  • 56
    • 0025190253 scopus 로고
    • Formation of the DNA adduct S-[2-(N7-guanyl)ethyl]glutathione from ethylene dibromide: Effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation
    • Kim, D.-H., and Guengerich, F. P. (1990) Formation of the DNA adduct S-[2-(N7-guanyl)ethyl]glutathione from ethylene dibromide: effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation. Carcinogenesis 11, 419-424.
    • (1990) Carcinogenesis , vol.11 , pp. 419-424
    • Kim, D.-H.1    Guengerich, F.P.2
  • 57
    • 0027191832 scopus 로고
    • Mutagenesis in Escherichia coll K-12 mutants defective in Superoxide dismutase or catalase
    • Prieto-Alamo, M. J., Abril, N., and Pueyo, C. (1993) Mutagenesis in Escherichia coll K-12 mutants defective in Superoxide dismutase or catalase. Carcinogenesis 14 237-244.
    • (1993) Carcinogenesis , vol.14 , pp. 237-244
    • Prieto-Alamo, M.J.1    Abril, N.2    Pueyo, C.3
  • 58
    • 0023750826 scopus 로고
    • 6alkylguanine-DNA-alkyltransferase activity in Chinese hamster V79 cells following selection with chloroethylating agents
    • 6alkylguanine-DNA-alkyltransferase activity in Chinese hamster V79 cells following selection with chloroethylating agents. Carcinogenesis 9, 45-49.
    • (1988) Carcinogenesis , vol.9 , pp. 45-49
    • Morten, J.E.N.1    Margison, G.P.2
  • 59
    • 0023130372 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colorimetric assay; assessment of chemosensitivity testing
    • Carmichael, J., De Giagg, W. G., Gazdav, A. F., Mina, J. D., and Mitchell, J. B. (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay; assessment of chemosensitivity testing. Cancer Res. 47, 936-942.
    • (1987) Cancer Res. , vol.47 , pp. 936-942
    • Carmichael, J.1    De Giagg, W.G.2    Gazdav, A.F.3    Mina, J.D.4    Mitchell, J.B.5
  • 60
    • 0029759506 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase are both required for its nuclear localization: The possible implications
    • 6-methylguanine-DNA methyltransferase are both required for its nuclear localization: the possible implications. EMBO J. 15, 4050-4060.
    • (1996) EMBO J. , vol.15 , pp. 4050-4060
    • Lim, A.1    Li, B.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.