O6-Benzylguanine in humans: Metabolic, pharmacokinetic, and pharmacodynamic findings

Journal of Clinical Oncology

Volumn 16, Issue 5, 1998, Pages 1803-1810

  Dolan, M Eileen ^a   Roy, Sandip K ^a   Fasanmade, Adedigbo A ^a   Paras, Phillip R ^a   Schilsky, Richard L ^a   Ratain, Mark J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O BENZYLGUANINE; ALKYLATING AGENT; CARMUSTINE; O6 BENZYL 8 OXOGUANINE; PROCARBAZINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; GUANINE; O(6) BENZYL 8 OXOGUANINE; O(6) BENZYLGUANINE; O(6)-BENZYL-8-OXOGUANINE; O(6)-BENZYLGUANINE; TRANSFERASE;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFICACY; DRUG ELIMINATION; DRUG MECHANISM; DRUG METABOLISM; DRUG SAFETY; DRUG STRUCTURE; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; SOLID TUMOR; BLOOD; ENZYMOLOGY; HALF LIFE TIME; METABOLISM; MONONUCLEAR CELL; NEOPLASM;

ALKYL AND ARYL TRANSFERASES; ANTINEOPLASTIC AGENTS; GUANINE; HALF-LIFE; HUMANS; INFUSIONS, INTRAVENOUS; LEUKOCYTES, MONONUCLEAR; NEOPLASMS;

EID: 0031596929     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1998.16.5.1803     Document Type: Article

References (27)

1. Colvin M, Chabner BA: Alkylating agents, in Chabner BA, Collms JM (eds): Cancer Chemotherapy Principles and Practice. Philadelphia, PA, Lippincott, 1990, pp 276-313
2. Chang CH, Horton J, Schoenfield D, et al: Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. Cancer 52:997-1007, 1985
3. 6-alkylguanine-DNA alkyltransferase. Prog Nucleic Acid Res Mol Biol 51:167-223, 1995
4. 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci USA 87:5368-5372, 1990
5. 6-alkylguanine-DNA alkyltransferase. J Med Chem 35:4486-4491, 1992
6. 6-benzylguanine analogs on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. Cancer Res, 51:3367-3372, 1991
7. 6-alkylguanine-DNA alkyltransferase. J Cancer Res Clin Oncol 121:225-229, 1995
8. 6-alkylguanine-DNA transferase correlates with potentiation of temozolomide and CCNU toxicity in human tumor cells. Br J Cancer 67:1299-1302, 1993
9. 6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation. Cancer Res 52:1171-1175, 1992
10. Friedman HS, Dolan ME, Moschel RC, et al: Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. J Natl Cancer Inst 84:1926-1931, 1992
11. 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Chem Pharmacol 32:471-476, 1993
12. 6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Biochem Pharmacol 46: 285-290, 1993
13. 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone. Biochem Pharmacol 45:483-491, 1993
14. 6-benzylguanine. Biochemistry 32:11998-12006, 1993
15. Kohn KW: Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl )-1-nitrosoureas. Cancer Res 37:1450-1454, 1977
16. Ludlum DB: DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal. Mutat Res 233:117-126, 1990
17. Lemoine A, Lucas C, Ings RM: Metabolism of the chloroethylnitrosoureas. Xenobiotica 21:775-791, 1991
18. 6-benzylguanine (BG) in patients with advanced cancer. Proc Am Soc Clin Oncol 15:176, 1996 (abstr)
19. 6-alkylguanine DNA alkyltransferase directed DNA repair. Proc Am Soc Clin Oncol 15:177, 1996 (abstr)
20. 6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents. Cancer Res 46:4500-4504, 1986
21. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal Biochem 72:248-254, 1976
22. 6-alkylguanine-DNA alkyltransferase. Cancer Res 54:5123-5130, 1994
23. 6-methylguanine-DNA methyltranserase inhibition in the nonhuman primate. Cancer Res 55:4606-4610, 1995
24. 6-benzylguanine in rats and its metabolism by rat liver microsomes. Drug Metab Dispos 23:1394-1399, 1995
25. 6-benzylguanine. Biochem Pharmacol 50: 1385-1389, 1995
26. Wrighton SA, Stevens JC: The human hepatic cytochromes P450 involved in drug metabolism. Crit Rev Toxicol 22:1-21, 1992
27. 6-alkylguanine alkyltransferase directed DNA repair in metastatic colon cancers. J Clin Oncol 13:2301-2308, 1995