A new model for how O6-methylguanine-DNA methyltransferase binds DNA

Proteins: Structure, Function and Genetics

Volumn 32, Issue 1, 1998, Pages 3-6

  Vora, Roben A ^a   Pegg, Anthony E ^b   Ealick, Steven E ^a  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Chemotherapy; DNA binding protein; DNA repair; Extra helical nucleotide; Methyltransferase; Nucleotide flipping

Indexed keywords

DNA; DNA BINDING PROTEIN; GUANINE DERIVATIVE; HELIX LOOP HELIX PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLTRANSFERASE; NUCLEOTIDE; TRANSPOSASE; ADA C PROTEIN, E COLI; ADA-C PROTEIN, E COLI; BACTERIAL PROTEIN; ESCHERICHIA COLI PROTEIN; PEPTIDE FRAGMENT; VIRUS DNA;

ARTICLE; COMPUTER MODEL; CONFORMATIONAL TRANSITION; DNA BINDING; DNA REPAIR; DNA SEQUENCE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BACTERIOPHAGE MU; CHEMICAL STRUCTURE; COMPUTER SIMULATION; CONFORMATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; BACTERIOPHAGE MU; COMPUTER SIMULATION; DNA, VIRAL; ESCHERICHIA COLI PROTEINS; HELIX-TURN-HELIX MOTIFS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; TRANSPOSASES;

EID: 0032118965     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19980701)32:1<3::AID-PROT2>3.0.CO;2-O     Document Type: Article

References (35)

1. Lindahl, T., Sedgwick, B., Sekiguchi, M., Nakabeppu Y. Regulation and expression of the adaptive response to alkylating agents. Annu. Rev. Biochem. 57:133-157, 1988.
2. Samson, L. The suicidal DNA repair methyltransferases of microbes. Mol. Microbiol. 6:825-831, 1992.
3. 6-alkylguanine-DNA alkyltransferase. Prog. Nucleic Acid Res. Mol. Biol. 51:167-223, 1995.
4. 6-alkylguanine-DNA alkyltransferase. J. Biol. Chem. 272:8332-8339, 1997.
5. Saffhill, R., Margison, G.P., O'Connor, P.J. Mechanisms of carcinogenesis induced by alkylating agents. BBA 823:111-146, 1985.
6. Singer, B., Essigmann, J.M. Site-specific mutagenesis retrospective and prospective. Carcinogenesis 12:949-956, 1991.
7. 6-alkylguanine DNA alkyltransferase regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res. 50:6119-6129, 1990.
8. 6 methylguanine residues at codon 12. Chem. Res. Toxicol. 4:647-657, 1991.
9. 6-methylguanine-DNA methyltransferase from E. Coli. EMBO J. 13:1495-1501, 1994.
10. 6-methylguanine-DNA methyltransferase. In: "Novel Approaches in Anticancer Drug Design Molecular Modeling -New Treatment Strategies, Vol. 49." Zeller, W.J., D'Incalci, M., Newell D.R. (eds.). Basel: Karger, 1995:16-24.
11. Rost, B., Sander, C. Jury returns on structural prediction. Nature 360:540, 1992.
12. 6-alkylguanine-DNA alkyltransferase based on the C-terminal domain of the Ada protein from Eseherichia coli. Anti-Cancer Drug Des. 10:75-95, 1995.
13. 6-alkylguanine-DNA alkyltransferase. Prog. Nucleic Acid Res. Mol. Biol. 51:167-223, 1995.
14. Demple, B. In: "Protein Methylation." Pailk, W.K., Kim, K. (eds.). Boca Raton, FL: CRC Press, 1990.
15. Roberts, R. On base flipping. Cell 82:9-12, 1995.
16. Murzin, A.G., Brenner, S.E., Hubbard, T., Chothia, C. Scop: A structural classification of proteins database for the investigation of sequences and structures. J. Mol. Biol. 247:536-540, 1995.
17. Clubb, R.T., Omichinski, J.G., Savilahti, H. et al. A novel class of winged helix-turn-helix protein: The DNA-binding domain of Mu transposase. Structure 2:1041-1048, 1994.
18. 6-benzylguanine. Biochemistry 34:7113-7119, 1995.
19. 6-alkylguanine-DNA alkyltransferase activity. Proc. Am. Assoc. Cancer Res. 37:A2484, 1996.
20. Verdine, G.L. The flip side of DNA methylation. Cell 28:197-200, 1994.
21. Demple, B. DNA repair flips out. Curr. Biol. 5:719-721, 1995.
22. Cheng, X. DNA modification by methyltransferases. Curr. Opin. Struct. Biol. 5:4-10, 1995.
23. Cheng, X., Blumenthal, R. Finding a basis for flipping bases. Structure 4:639-645, 1996.
24. Klimasauskas, S., Kumar, S., Roberts, R., Cheng, X. HhaI methyltransferase flips its target base out of the DNA helix. Cell 76:357-369, 1994.
25. Cal, S., Connolly, B.A. DNA distortion and base flipping by the EcoRV DNA methyltransferase. J. Biol. Chem. 272:490-496, 1997.
26. Park, H., Kim, S., Sancar, A., Deisenhofer, J. Crystal structure of DNA photolyase from Escherichia coli. Science 268:1866-1872, 1995.
27. Vassylyev, D.G., Kashiwagi, T., Mikami, Y. et al. Atomic model of a pyrimidine dimer exchange excision repair enzyme complexed with a DNA substrate: Structural basis for damaged DNA recognition. Cell 83:773-782, 1995.
28. Labahn J., Schärer O.D., Long A. et al. Structural basis for the excision repair of alkylation-damaged DNA. Cell 86: 321-329, 1996.
29. Yamagata, Y., Kato, M., Odawara, K., Tokuno, Y., Nakashima, Y., Matsushima, N., Yasamura, K. Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli. Cell 86:311-319, 1996.
30. Thayer, M.M., Ahern, H., Xing, D., Cunningham, R.P., Tainer, J.A. Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure. EMBO J. 16:4108-4120, 1995.
31. Slupphaug, G., Moi, C., Kavli, B., Arvai, A., Krokan, H., Tainer, J. A nueleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature 384:87-92, 1996.
32. Takahashi, M., Sakumi, K., Sekiguchi, M. Interaction of Ada protein with DNA examined by fluorescence anisotropy of the protein. Biochemistry 29:3431-3436, 1990.
33. 6-methylguanine-DNA methyltransferase. Arch. Biochem. Biophys. 300:193-200, 1993.
34. 6meG-C-G) duplex. Biochemistry 25:1027-1036, 1986.
35. Altschul, S.F., Gish, W., Miller, W., Myers, E., Lipman D. Basic local alignment search tool. J. Mol. Biol 215:403-410, 1990.