Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine

Biochemical Journal

Volumn 347, Issue 2, 2000, Pages 527-534

  Xu Welliver, Meng ^a   Kanugula, Sreenivas ^a   Loktionova, Natalia A ^a   Crone, Tina M ^a   Pegg, Anthony E ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Alkylating agents; Chemotherapy; DNA repair; O6 methylguanine

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; ALKYLATING AGENT; ARGININE; LYSINE; MUTANT PROTEIN; 8 OXO O(6) BENZYLGUANINE; 8-OXO-O(6)-BENZYLGUANINE; ANTINEOPLASTIC AGENT; CARMUSTINE; DNA; DRUG DERIVATIVE; GUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLNITRONITROSOGUANIDINE; O(6) BENZYLGUANINE; O(6)-BENZYLGUANINE;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DNA BINDING; DNA METHYLATION; DNA REPAIR; ENZYME ACTIVITY; HUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; ESCHERICHIA COLI; GENETIC TRANSFECTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HAMSTER; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CARMUSTINE; CHO CELLS; CONSERVED SEQUENCE; CRICETINAE; DNA; DNA REPAIR; DRUG RESISTANCE; ESCHERICHIA COLI; GUANINE; HUMANS; LYSINE; METHYLNITRONITROSOGUANIDINE; MOLECULAR SEQUENCE DATA; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROTEIN BINDING; SEQUENCE ALIGNMENT; TRANSFECTION;

EID: 0034654658     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3470527     Document Type: Article

References (45)

1. 1 Lindahl, T., Sedgwick, B., Sekiguchi, M. and Nakabeppu, Y. (1988) Annu. Rev. Biochem. 57, 133-157
2. 2 Samson, L. (1992) Mol. Microbiol. 6, 825-831
3. 3 Pegg, A. E. and Byers, T. L. (1992) FASEB J. 6, 2302-2310
4. 4 Pegg, A. E., Dolan, M. E. and Moschel, R. C. (1995) Progr. Nucleic Acid Res. Mol. Biol. 51, 167-223
5. 5 Mitra, S. and Kaina, B. (1993) Progr. Nucleic Acid Res. Mol. Biol. 44, 109-142
6. 6 Moody, P. C. E. and Moore, M. E. (1995) in Novel Approaches in Anticancer Drug Design Molecular Modelling-New Treatment Strategies, vol. 49 (Zeller, W. J., D'Incalci, M. and Newell, D. R., eds.), pp. 16-24, Karger, Basel
7. 7 Goodtzova, K., Kanugula, S., Edara, S. and Pegg, A. E. (1998) Biochemistry 37, 12489-12495
8. 8 Demple, B. (1990) in Protein Methylation (Paik, W. K. and Kim, S., eds.), pp. 285-304, CRC Press, Boca Raton, Florida
9. 9 Spratt, T. E. and Campbell, C. R. (1994) Biochemistry 33, 11364-11371
10. 10 Harris, L. C., Potter, P. M. and Margison, G. P. (1992) Biochem. Biophys. Res. Comm. 187, 425-431
11. 11 Crone, T. M. and Pegg, A. E. (1993) Cancer Res. 53, 4750-4753
12. 12 Hazra, T. K., Roy, R., Biswas, T., Grabowski, D. T., Pegg, A. E. and Mitra, S. (1997) Biochemistry 36, 5769-5776
13. 13 Ihara, K., Kawate, H., Chueh, L. L., Hayakawa, H. and Sekiguchi, M. (1994) Mol. Gen. Genet. 243, 379-389
14. 14 Crone, T. M., Goodtzova, K. and Pegg, A. E. (1996) Mutation Res. 363, 15-25
15. 15 Pieper, R. O., Morgan, S. E. and Kelley, M. R. (1994) Carcinogenesis 15, 1895-1902
16. 16 Kanugula, S., Goodtzova, K., Edara, S. and Pegg, A. E. (1995) Biochemistry 34, 7113-7119
17. 17 Xu-Welliver, M. and Pegg, A. E. (2000) Biochem. J. 347, 519-526
18. 18 Moore, M. H., Gulbus, J. M., Dodson, E. J., Demple, B. and Moody, P. C. E. (1994) EMBO J. 13, 1495-1501
19. 19 Hashimoto, H., Inoue, T., Nishioka, M., Fujiwara, S., Takagi, M., Imanaka, T. and Kai, Y. (1999) J. Mol. Biol. 292, 707-716
20. 20 Wibley, J. E. A., Pegg, A. E. and Moody, P. C. E. (2000) Nucleic Acids Res. 28, 393-401
21. 21 Demple, B. (1995) Curr. Biol. 5, 719-721
22. 22 Roberts, R. J. and Cheng, X. (1998) Annu. Rev. Biochem. 67, 181-198
23. 23 Vora, R., Pegg, A. E. and Ealick, S. E. (1998) Proteins 32, 3-6
24. 24 Parikh, S. S. Mol, C. D. and Tainer, J. A. (1997) Structure 5, 1543-1550
25. 25 Parikh, S. S., Mol, C. D., Slupphaug, G., Bharati, S., Krokan, H. E. and Tainer, J. A. (1998) EMBO J. 17, 5214-5226
26. 26 Yamagata, Y., Kato, M., Odawara, K., Tokuno, Y., Nakashima, Y., Matsushima, N. and Yasamura, K. (1996) Cell 86, 311-319
27. 27 Labahn, J., Schärer, O. D., Long, A., Ezaz-Nikpay, K., Verdine, G. L. and Ellenberger, T. E. (1996) Cell 86, 321-329
28. 28 Rebeck, G. W. and Samson, L. (1991) J. Bacteriol. 173, 2068-2076
29. 29 Dolan, M. E., Moschel, R. C. and Pegg, A. E. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 5368-5372
30. 30 Xu-Welliver, M., Kanugula, S. and Pegg, A. E. (1998) Cancer Res 59, 1936-1945
31. 31 Pegg, A. E., Boosalis, M., Samson, L., Moschel, R. C., Byers, T. L., Swenn, K. and Dolan, M. E. (1993) Biochemistry 32, 11998-12006
32. 32 Edara, S., Kanugula, S., Goodtzova, K. and Pegg, A. E. (1996) Cancer Res. 56, 5571-5575
33. 33 Loktionova, N. A. and Pegg, A. E. (1996) Cancer Res. 56, 1578-1583
34. 34 Kanugula, S., Goodtzova, K. and Pegg, A. E. (1998) Biochem. J. 329, 545-550
35. 35 Xu-Welliver, M., Leitao, J., Kanugula, S. and Pegg, A. E. (1999) Cancer Res. 59, 1514-1519
36. 36 Trimmer, E. E., Zamble, D. B., Lippard, S. J. and Essigmann, J. M. (1998) Biochemistry 37, 352-362
37. 37 Loktionova, N. A., Xu-Welliver, M., Crone, T., Kanugula, S. and Pegg, A. E. (1999) Biochem. Pharmacol. 58, 237-244
38. 38 Lindahl, T. (1993) Nature (London) 362, 709-715
39. 39 Lindahl, T. (1996) Philos. Trans. R. Soc. London Ser. B 351, 1529-1538
40. 40 Taverna, P. and Sedgwick, B. (1996) J. Bacteriol. 178, 5105-5111
41. 41 Goodtzova, K., Kanugula, S., Edara, S., Pauly, G. T., Moschel, R. C. and Pegg, A. E. (1997) J. Biol. Chem. 272, 8332-8339
42. 42 Wang, L., Spratt, T. E., Liu, X.-L., Hecht, S. S., Pegg, A. E. and Peterson, L. A. (1997) Chem. Res. Toxicol. 10, 562-567
43. 43 Ciocco, G. M., Pegg, A. E., Moschel, R. C., Chae, M.-Y., McLaughlin, P. J., Zagon, I. S. and Pegg, A. E. (1995) Cancer Res. 55, 4085-4091
44. 44 Dolan, M. E. and Pegg, A. E. (1997) Clin. Cancer Res. 3, 837-847
45. 45 Dolan, M. E. (1997) Adv. Drug Delivery Rev. 26, 105-118