Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A3 adenosine receptor antagonists: Influence of the chain at the N8 pyrazole nitrogen

Journal of Medicinal Chemistry

Volumn 43, Issue 25, 2000, Pages 4768-4780

  Baraldi, P G ^a   Cacciari, B ^a   Romagnoli, R ^a   Spalluto, G ^b   Moro, S ^c   Klotz, K N ^d   Leung, E ^e   Varani, K ^a   Gessi, S ^a   Merighi, S ^a   Borea, P A ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e Medco Research Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR BLOCKING AGENT; CYCLIC AMP; METHYL GROUP; NITROGEN; PYRAZOLE; PYRAZOLO[4,3 E]1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; HUMAN; NONHUMAN; PHARMACOPHORE; RADIOASSAY; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; PYRIMIDINES; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034649648     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001047y     Document Type: Article

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