Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4- dihydropyridines as highly selective A3 adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 40, Issue 16, 1997, Pages 2596-2608

  Jiang, Ji Long ^a   Van Rhee, A Michiel ^a   Chang, Louis ^a   Patchornik, Abraham ^a,c   Ji, Xiao Duo ^a   Evans, Patricia ^a   Melman, Neli ^a   Jacobson, Kenneth A ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Molecular Recognition Section   (United States)

^c Box 271   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

(4 AMINO 3 IODOBENZYL) 5' (N METHYLCARBAMOYL)ADENOSINE; 4 (PHENYLETHYNYL) 6 PHENYL 1,4 DIHYDROPYRIDINE; 5 [2 (TRIMETHYLSILYL)ETHYL] ESTER; ADENOSINE RECEPTOR BLOCKING AGENT; ADENYLATE CYCLASE; DIHYDROPYRIDINE DERIVATIVE; PHOSPHOLIPASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL DEATH; CELL STRAIN HL 60; ENZYME ACTIVITY; LIGAND BINDING; MOLECULAR CLONING; NONHUMAN; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ADENOSINE; AFFINITY LABELS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; DIHYDROPYRIDINES; HUMANS; IODINE RADIOISOTOPES; KINETICS; MODELS, CHEMICAL; RATS; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030796012     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970091j     Document Type: Article

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