Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 12, 1996, Pages 2293-2301

  Karton, Yishai ^a   Jiang, Ji Long ^a   Ji, Xiao Duo ^a   Melman, Neli ^a   Olah, Mark E ^b   Stiles, Gary L ^b   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2',4',3,7 TETRAETHOXY 5 HYDROXYFLAVONE; 3 HYDROXY 6 METHOXY 2 STYRYLFLAVANONE; 3,5,7 TRIPROPOXYFLAVONE; 3,6 DICHLORO 2' ISOPROPOXY 4' METHYLFLAVONE; 4 ETHOXY 7 STYRYLVISNAGIN; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; FLAVANOID; FLAVANOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTHMA; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; INFLAMMATION; NONHUMAN; RECEPTOR AFFINITY; STROKE;

ANIMALS; BRAIN CHEMISTRY; CHO CELLS; CRICETINAE; DRUG DESIGN; FLAVONOIDS; HUMANS; KINETICS; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029893998     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950923i     Document Type: Article

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