Sustained activation of phospholipase D via adenosine A3 receptors is associated with enhancement of antigen- and Ca2+-ionophore-induced secretion in a rat mast cell line

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 2, 1996, Pages 837-845

  Ali, Hydar ^a,b   Choi, Oksoon H ^a   Fraundorfer, Paul F ^a   Yamada, Koji ^a,c   Gonzaga, Heloisa M S ^a,d   Beaven, Michael A ^a,e  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c EISAI CO LTD   (Japan)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR; ANTIGEN; CALCIMYCIN; CALCIUM; DIACYLGLYCEROL; DRUG DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; IONOPHORE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN KINASE C;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; DOSE RESPONSE; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYMOLOGY; IMMUNOLOGY; MAST CELL; METABOLISM; PHYSIOLOGY; RAT; SECRETION;

ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMALS; ANTIGENS; CALCIMYCIN; CALCIUM; CELLS, CULTURED; DIGLYCERIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GTP-BINDING PROTEINS; IONOPHORES; MAST CELLS; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN KINASE C; RATS; RECEPTORS, PURINERGIC P1;

EID: 0030088087     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. ALI, H., CUNHA-MELO, J. R., SAUL, W. F. AND BEAVEN, M. A., The activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen stimulated RBL-2H3 cells: Evidence for a novel adenosine receptor. J. Biol. Chem. 265: 745-753, 1990.
2. 2+ stores. Biochem. J. 304: 431-440, 1994.
3. ALI, H., MULLER, C. E., DALY, J. W. AND BEAVEN, M. A.: Methylxanthines block antigen-induced responses in RBL-2H3 cells independently of adenosine receptors or cyclic AMP: Evidence for inhibition of antigen binding to IgE. J. Pharm Exp. Ther. 258: 954-962, 1991.
4. BEAVEN, M. A. AND CUNHA-MELO, J. R.: Membrane phosphoinositide-activated signals in mast cells and basophils Progr. Allergy 42: 123-184, 1988.
5. BEAVEN, M. A., GUTHRIE, D. F., MOORE, J. P., SMITH, G. A., HESKETH, T. R. AND METCALFE, J. C : Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: Evidence for an unidentified signal required for histamine release. J. Cell Biol. 105: 1129-1136, 1987.
6. 3 receptors in mast cells. Trends Pharmacol. Sci. 15: 13-14, 1994.
7. BEAVEN, M. A., ROGERS, J , MOORE, J. P., HESKETH, T. R., SMITH, G. A. AND METCALFE, J. C.: The mechanism of the calcium signal and correlation with histamine release in 2H3 cells. J. Biol. Chem. 259: 7129-7136, 1984.
8. BENHAMOU, M., GUTKIND, J. S., ROBBINS, K. C. AND SIRAGANIAN, R. P.: Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. Proc. Natl. Acad. Sci. U.S.A. 87: 5327-5330, 1990.
9. BENHAMOU, M. AND SIRAGANIAN, R P.: Protein-tyrosine phosphorylation: An essential component of FcεRI signaling. Immunol. Today 13: 195-197, 1992
10. BENHAMOU, M., STEPHAN, V., ROBBINS, K. C. AND SIRAGANIAN, R. P.: High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations. J. Biol. Chem. 267: 7310-7314, 1992.
11. BILLAH, M. M.: Phospholipase D and cell signaling. Curr. Opin. Immunol. 5: 114-123, 1993.
12. BILLAH, M. M. AND ANTHES, J. C.: The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem. J. 269: 281-291, 1990.
13. BLIGH, E. G. AND DYER, W. J.: A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37: 911-917, 1959
14. BOWMAN, E. P., UHILINGER, D. J. AND LAMBETH, J. D.: Neutrophil phospholipase D is activated by a membrane-associated Rho family of small molecular weight GTP-binding protein. J. Biol. Chem. 268: 21509-21512, 1993.
15. BOYER, J. L., GRABER, S. G., WALDO, G. L., HARDEN, T. K. AND GARRISON, J. C.: Selective activation of phospholipase C by recombinant G-protein α- and βγ-subunits. J. Biol. Chem. 269: 2814-2819, 1994
16. 2b adenosine receptor in NIH 3T3 fibroblasts. Biochem. Pharmacol. 47: 801-814, 1994.
17. BROWN, A. H., GUTOWSKI, S., MOOMAW, C. R., SLAUGHTER, C. AND STERNWEISS, P. C.: ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity. Cell 75: 1137-1144, 1993
18. 3H]NECA in rat striatal membranes. Mol. Pharmacol. 29: 331-346, 1986.
19. CHOI, O. H., ADELSTEIN, R. S. AND BEAVEN, M. A.: Secretion from rat basophilic RBL-2H3 cells is associated with phosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by protein kinase C. J. Biol Chem. 269: 536-541, 1994.
20. CHURCH, M. K. AND HOLGATE, S. T.: Adenosine-induced bronchoconstriction and its inhibition by nedocromil sodium. J. Allergy Clin. Immunol. 92: 190-194, 1993.
21. CHURCH, M. K., HUGHES, P. J. AND VARDEY, C. J.: Studies on the receptor mediating cyclic AMP-independent enhancement by adenosine of IgE-dependent mediator release from rat mast cells. Br. J. Pharmacol. 87: 233-242, 1986.
22. COCKCROFT, S., THOMAS, G. M., FENSOME, A., GENY, B., CUNNINGHAM, E., GOUT, I., HILES, I., TOTTY, N. F., TRUONG, O. AND HSUAN, J. J.: Phospholipase D: A downstream effector of ARF in granulocytes. Science 263: 523-526, 1994.
23. COLLADO-ESCOBAR, D., ALI, H. AND BEAVEN, M. A.: On the mechanism of action of dexamethasone in a rat mast cell line (RBL-2H3 cells): Evidence for altered coupling of receptors and G-proteins. J. Immunol. 144: 3449-3457, 1990a.
24. COLLADO-ESCOBAR, D , CUNHA-MELO, J. R. AND BEAVEN, M. A.: Treatment with dexamethasone down-regulates IgE-receptor mediated signals and upregulates adenosine-receptor mediated signals in a rat mast cell (RBL-2H3) line. J. Immunol 144: 244-250, 1990b.
25. EISEMAN, E. AND BOLEN, J. B.: Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 355: 78-80, 1992.
26. GALLI, S. J.: New concepts about the mast cell. N. Engl. J. Med. 328: 257-265, 1993.
27. GRUCHALLA, R. S., DINH, T. T. AND KENNERLY, D. A.: An indirect pathway of receptor-mediated 1,2-diacylglycerol formation in mast cells. I. IgE receptor-mediated activation of phospholipase D. J. Immunol. 144: 2334-2342, 1990.
28. αz: Its down regulation by dexamethasone and its credentials as a mediator of antigen-induced responses in RBL-2H3 cells. Mol. Pharm. 40: 473-479, 1991.
29. HUTCHCROFT, J. E., GEAHLEN, R. L., DEANIN, G. G AND OLIVER, J. M.: FcεRI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc. Natl. Acad. Sci. U.S.A. 89: 9107-9111, 1992.
30. JONES, S. V. P., CHOI, O. H. AND BEAVEN, M. A.: Carbachol induces secretion in a mast cell line (RBL-2H3) transfected with the m1 muscarinic receptor gene. FEBS Lett. 289: 47-50, 1991.
31. JOUVIN, M.-H. E., ADAMCZEWSKI, M., NUMEROF, R., LETOURNEUR, O., VALLE, A. AND KINET, J.-P.: Differential control of the tyrosine kinases lyn and syk by the two signaling chains of the high affinity immunoglobulin E receptor. J. Biol. Chem 269: 5918-5925, 1994.
32. KENNERLY, D. A.: Diacylglycerol metabolism in mast cells. Analysis of lipid metabolic pathways using molecular species analysis of intermediates. J. Biol. Chem. 262: 16305-16313, 1987.
33. KIKKAWA, U., MINAKUCHI, R., TAKAI, Y. AND NISHIZUKA, Y.: Calcium-activated, phospholipid-dependent protein kinase (protein kinase C) from rat brain. Methods Enzymol. 99: 288-298, 1983.
34. LIBERT, F., PARMENTIER, M., LEFORT, A., DINSART, C., VAN SANDE, J., MAENHAUT, C., SIMONS, M. J., DUMONT, J. E. AND VASSART, G.: Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science 244: 569-572, 1989.
35. LIN, P., WIGGAN, G. A AND GILFILLAN, A. M.: Activation of phospholipase D in a rat mast (RBL-2H3) cell line: A possible unifying mechanism for IgE-dependent degranulation and arachidonic acid metabolite release. J. Immunol. 146: 1609-1616, 1991.
36. 3 receptors: Pharmacological properties, species differences and receptor functions. Trends Pharmacol. Sci. 15: 298-306, 1994.
37. 3 adenosine receptor with widespread tissue distribution. Mol. Pharmacol. 44: 524-532, 1993.
38. 2+ ionophores on rat basophilic (2H3) cells are dependent on cellular ATP and hydrolysis of inositol phospholipids. A comparison with antigen stimulation J Biol. Chem. 262: 4141-4145, 1987.
39. 2+ sensitivity of mast cell mediator release. Proc. Natl. Acad Sci. U.S.A. 85: 8875-8879, 1988.
40. LOHSE, M. J., MAURER, K., KLOTZ, K. N. AND SCHWABE, U.: Synergistic effects of calcium-mobilizing agents and adenosine on histamine release from rat peritoneal mast cells. Br. J. Pharmacol. 98: 1392-1398, 1989.
41. LUDOWYKE, R. I., PELEG, I., BEAVEN, M. A AND ADELSTEIN, R. S.: Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells. J. Biol. Chem. 264: 12492-12501, 1989
42. MAEYAMA, K., HOHMAN, R. J., ALI, H., CUNHA-MELO, J. R. AND BEAVEN, M. A : Assessment of IgE-receptor function through measurement of hydrolysis of membrane inositol phospholipids. New insights on the phenomena of biphasic antigen concentration-response curves and desensitization. J. Immunol. 140: 3919-3927, 1988.
43. 1 adenosine receptor from rat brain. Mol. Pharmacol. 40: 1-7, 1991.
44. MARQUARDT, D. L. AND WALKER, L. L.: Alteration of mast cell responsiveness to adenosine by pertussis toxin. Biochem. Pharmacol. 37: 4019-4025, 1988
45. MARQUARDT, D. L AND WALKER, L. L.: Pretreatment with phorbol ester abrogates mast cell adenosine responsiveness J. Immunol 142: 1268-1273, 1989.
46. MARQUARDT, D. L., WALKER, L. L. AND HEINEMANN, S.: Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. J. Immunol. 152: 4508-4515, 1994.
47. METZGER, H., ALCARAZ, G., HOHMAN, R., KINET, J. P., PRIBLUDA, V. AND QUARTO, R.: The receptor with high affinity for immunoglobulin E. Annu. Rev. Immunol. 4: 419-470, 1986.
48. MILLARD, P. J., RYAN, T., WEBB, W. W. AND FEWTRELL, C.: Immunoglobulin E receptor cross-linking induces oscillations in intracellular free ionized calcium in individual tumor mast cells. J. Biol. Chem. 264: 19730-19739, 1989.
49. OTT, I., LOHSE, M J., KLOTZ, K. N., VOGT-MOYKOPF, I. AND SCHWABE, U.: Effects of adenosine on histamine release from human lung fragments. Int. Arch. Allergy Immunol. 98: 50-56, 1992.
50. 2+ and purified isozymes in washed permeabilized cells. J. Biol. Chem. 268: 1749-1756, 1993a.
51. OZAWA, K., YAMADA, K., KAZANIETZ, M. G., BLUMBERG, P. AND BEAVEN, M. A.: Different isozymes of protein kinase C mediate feed-back inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells. J. Biol. Chem. 268: 2280-2283, 1993b.
52. PARK, D J , MIN, H K. AND RHEE, S. G.: IgE-induced tyrosine phosphorylation of phospholipase C-γ1 in rat basophilic leukemia cells. J. Biol. Chem. 266: 24237-24240, 1991.
53. PEACHELL, P. T., COLUMBO, M., KAGEY-SOBOTKA, A., LICHTENSTEIN, L. M. AND MARONE, G.: Adenosine potentiates mediator release from human lung mast cells. Am. Rev. Respir Dis. 138: 1143-1151, 1988
54. PREISS, J., LOOMIS, C. R., BISHOP, W. R., STEIN, R., NIEDEL, J. E. AND BELL, R M.: Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells. J. Biol. Chem. 261: 8597-8600, 1986.
55. 3R is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J. Biol. Chem. 268: 16887-16890, 1993.
56. 3 adenosine receptors in rat basophilic leukemia (RBL-2H3) cells. J. Immunol. 154: 5436-5443, 1995.
57. 3 adenosine receptor. Biochim. Biophys. Acta 1179: 105-107, 1993.
58. 3 adenosine receptor. Proc. Natl. Acad. U.S.A. 90: 10365-10369, 1993.
59. SHUKLA, S. D. AND HALENDA, S. P.: Phospholipase D in cell signalling and its relationship to phospholipase C. Life. Sci 48: 851-866, 1991.
60. SIDDIQI, A R., SMITH, J. L., ROSS, A. H , QUI, R.-G., SYMONS, M. AND EXTON, J. H.: Regulation of phospholipase D in HL60 cells. Evidence for a cytosolic phospholipase D. J. Biol Chem. 270: 8466-8473, 1995.
61. 2-adenosine receptor subtype. Mol. Endocrinol. 6: 384-393, 1992
62. TESHIMA, R., SUZUKI, K., IKEBUCHI, H. AND TERAO, T.: Enhancement of the phosphorylation of membrane bound myosin light chain by antigen stimulation in rat basophilic leukemia cells. Mol. Immunol. 26: 641-648, 1989.
63. 2b receptor in Xenopus oocytes. Mol. Pharmacol. 43: 277-280, 1993.
64. YAMADA, K., JELSEMA, C. L. AND BEAVEN, M. A.: Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine-phosphorylation of phospholipase Cγ1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells. J. Immunol. 149: 1031-1037, 1992.
65. 3 adenosine receptor. Proc. Natl. Acad Sci. U.S.A. 89: 7432-7436, 1992.