Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists

Journal of Medicinal Chemistry

Volumn 41, Issue 17, 1998, Pages 3174-3185

  Baraldi, Pier Giovanni ^a   Cacciari, Barbara ^a   De Las Infantas, Maria José Pineda ^a   Romagnoli, Romeo ^a   Spalluto, Giampiero ^a   Volpini, Rosaria ^b   Costanzi, Stefano ^b   Vittori, Sauro ^b   Cristalli, Gloria ^b   Melman, Neli ^c   Park, Kyung Sun ^c   Ji, Xiao Duo ^c   Jacobson, Kenneth A ^c  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [6 [[(3 IODOPHENYL)METHYL]AMINO] 9H PURIN 9 YL] 1 DEOXY N METHYL BETA DEXTRO RIBOFURANURONAMIDE; 1 DEOXY 1 [6 [[[(4 SULFONAMIDOPHENYL)AMINO]CARBONYL]AMINO] 9H PURIN 9 YL] N ETHYL BETA DEXTRO RIBOFURANURONAMIDE; 2 (3 HYDROXY 3 PHENYL 1 PROPYN 1 YL) 1 DEOXY 1 [6 [[[(4 METHOXYPHENYL)AMINO]CARBONYL]AMINO] 9H PURIN 9 YL] N ETHYL BETA DEXTRO RIBOFURANURONAMIDE; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMALS; BRAIN; CARBAMATES; CELL LINE; CELL MEMBRANE; DRUG DESIGN; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); INDICATORS AND REAGENTS; KINETICS; MAST CELLS; MOLECULAR STRUCTURE; RATS; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15444352073     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980147p     Document Type: Article

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