Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A(2A) adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 41, Issue 12, 1998, Pages 2126-2133

  Baraldi, Pier Giovanni ^a   Cacciari, Barbara ^a   Spalluto, Giampiero ^a   Bergonzoni, Manuela ^a   Dionisotti, Silvio ^b   Ongini, Ennio ^b   Varani, Katia ^a   Borea, P A ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b Parco Scientifico San Raffaele   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 2 (2 FURYL) 7 (3 PHENYLPROPYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 7 [3 (3,4 DIMETHOXYPHENYL)PROPYL] 2 (2 FURYL)PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 7 [3 [3,4 (METHYLENEDIOXY)PHENYL]PROPYL] 2 (2 FURYL)PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 7 [3 [4 HYDROXYPHENYL)PROPYL] 2 (2 FURYL)PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE RECEPTOR BLOCKING AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; DEGENERATIVE DISEASE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MALE; NONHUMAN; PARKINSON DISEASE; RAT;

ADENOSINE; ANIMALS; BINDING, COMPETITIVE; BLOOD PLATELETS; CHO CELLS; CORPUS STRIATUM; CRICETINAE; CYCLIC AMP; DRUG DESIGN; HUMANS; MALE; MICE; PHENETHYLAMINES; PYRAZOLES; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TUMOR CELLS, CULTURED;

EID: 0032482371     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9708689     Document Type: Article

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