Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1β-converting enzyme inhibitor

Journal of Medicinal Chemistry

Volumn 40, Issue 13, 1997, Pages 1941-1946

  Dolle, R E ^a   Prasad, C V C ^a   Prouty, C P ^a   Salvino, J M ^a   Awad, M M A ^a   Schmidt, S J ^a   Hoyer, D ^a   Ross, T M ^a   Graybill, T L ^a   Speier, G J ^a   Uhl, J ^a   Miller, B E ^a   Helaszek, C T ^a   Ator, M A ^a  

^a PHARMACOPEIA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; PYRIDAZINODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME REGULATION; HYDROGEN BOND; HYPOTHESIS;

ANIMALS; AZEPINES; DOGS; DRUG DESIGN; ENZYME INHIBITORS; METABOLIC CLEARANCE RATE; PYRIDAZINES; SERPINS; VIRAL PROTEINS;

EID: 17144451277     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9701637     Document Type: Article

References (0)