In search of an enzyme: The β-secretase of Alzheimer's disease is an aspartic proteinase

Trends in Neurosciences

Volumn 23, Issue 11, 2000, Pages 565-570

  Howlett, David R ^a   Simmons, David L ^a   Dingwall, Colin ^a   Christie, Gary ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; CP 108671; ENZYME; GAMMA SECRETASE; INDINAVIR; MEMBRANE PROTEIN; PROTEIN PRECURSOR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; DRUG BIOAVAILABILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LABORATORY; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; TISSUE DISTRIBUTION;

EID: 0034333041     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(00)01647-7     Document Type: Review

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