Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 18, 1996, Pages 2157-2162

  Whitesitt, Celia A ^a   Simon, Richard L ^a   Reel, Jon K ^a   Sigmund, Sandra K ^a   Phillips, Michael L ^a   Shadle, J Kevin ^a   Heinz, Lawrence J ^a   Koppel, Gary A ^a   Hunden, David C ^a   Lifer, Sherryl L ^a   Berry, Dennis ^a   Ray, Judy ^a   Little, Sheila P ^a   Liu, Xiadong ^a   Marshall, Winston S ^a   Panetta, Jill A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPHENONE DERIVATIVE; CATHEPSIN D; ENZYME INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORESCENCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 0030591686     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00393-9     Document Type: Article

References (14)

1. 1. Barrett, A. J. Cellular Proteolysis, An Overview. Annals New York Academy of Sciences, 1992, 674, 1.
2. 2. Cataldo, A. M.; and Nixon, R. A. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 3861.
3. 3. Nakamura, Y; Takeda, M; Suzuki, H; Hattori, H; Tada, K; Hariguchi, S; Husahimoto, S; Nishimura, T. Neurosci. Lett., 1991, 130, 195.
4. 4. Ladror, U. S.; Snyder S. W.; Wang, G. T.; Holzman, T. F.; Krafft, G. A. J Biol Chem. 1994, 269, 18422.
5. 5. Dreyer, R. N.; Bausch, K. M.; Fracasso, P.; Hammond, L. J.; Wunderlich, D; Wirak, D. O.; Davis, G; Brini, C. M.; Buckholz, T. M.; Konig, G.; Kamarck, M. E.; Tamburini, P. P. Eur. J. Biochem. 1994, 224, 265
6. 6. Leto, G.; Gebbia, N.; Rausa, L.; Tumminello, F. M. Cathepsin D in the malignant progression of neoplastic diseases (review). Anticancer Res, 1992, 12, 235-40.
7. 7. Rochefort, H. Acta Oncol, 1992, 31, 125.
8. 8. Simon, D. I.; Ezratty, A. M.; Loscalzo, J. Biochem. 1994, 33, 6555.
9. 9. Conover, C. A.; DeLeon; D. D. J Biol Chem. 1994, 269, 7076.
10. 10. Lenarcic, B.; Krasovec, M.; Ritonja, A.; Clafsson, I.; Turk, V. FEBS Lett. 1991, 280, 211.
11. 11. Dillard, R. D.; Carr, F. P.; McCullough, D.; Haisch, K. D.; Rinkema, L. E.; Fleisch, J. H. J Med Chem. 1987, 30, 911.
12. 12. Panetta, J. A Unpublished results. X-ray results from one analog.
13. 13. Marshall, W. S.; Goodson, T.; Cullinan, G. J.; Swanson-Bean, D.; Haisch, K. D.; Rinkema, L. E.; Fleisch, J. H. J Med Chem. 1986, 30, 682.
14. 14. Murakami, K.; Ohsawa, T.; Hirose, S.; Takeada, K.; Sakakibara, S Anal Biochem. 1981, 110, 232.