메뉴 건너뛰기




Volumn 48, Issue 2, 1997, Pages 206-214

Expression and characterization of human β-secretase candidates metalloendopeptidase MP78 and cathepsin D in βAPP-overexpressing cells

Author keywords

Secretase; Alzheimer's disease; Amyloid protein; Amyloidogenic cleavage; Cathepsin D; Expression; Metalloendopeptidase

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CATHEPSIN D; METALLOPROTEINASE; METHIONINE;

EID: 0030880059     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00091-0     Document Type: Article
Times cited : (13)

References (29)
  • 2
    • 0029975425 scopus 로고    scopus 로고
    • Evaluation of cathepsin D and G and EC 3.4.24.15 as candidate β-secretase proteases using peptide and amyloid precursor protein substrates
    • Brown A.M., Tummolo D.M., Spruyt M.A., Jacobsen J.S., Sonnenberg-Reines J. Evaluation of cathepsin D and G and EC 3.4.24.15 as candidate β-secretase proteases using peptide and amyloid precursor protein substrates. J. Neurochem. 66:1996;2436-2445.
    • (1996) J. Neurochem. , vol.66 , pp. 2436-2445
    • Brown, A.M.1    Tummolo, D.M.2    Spruyt, M.A.3    Jacobsen, J.S.4    Sonnenberg-Reines, J.5
  • 3
    • 0028947294 scopus 로고
    • Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
    • Cataldo A.M., Barnett J.L., Berman S.A., Li J., Quarless S., Bursztajn S., Lippa C., Nixon R.A. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron. 14:1995;671-680.
    • (1995) Neuron , vol.14 , pp. 671-680
    • Cataldo, A.M.1    Barnett, J.L.2    Berman, S.A.3    Li, J.4    Quarless, S.5    Bursztajn, S.6    Lippa, C.7    Nixon, R.A.8
  • 4
    • 0029379605 scopus 로고
    • Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease
    • Checler F. Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 65:1995;1431-1444.
    • (1995) J. Neurochem. , vol.65 , pp. 1431-1444
    • Checler, F.1
  • 5
    • 0028924248 scopus 로고
    • Generation of amyloid β protein from its precursor is sequence specific
    • Citron M., Teplow D.B., Selkoe D.J. Generation of amyloid β protein from its precursor is sequence specific. Neuron. 14:1995;661-670.
    • (1995) Neuron , vol.14 , pp. 661-670
    • Citron, M.1    Teplow, D.B.2    Selkoe, D.J.3
  • 6
    • 0029933172 scopus 로고    scopus 로고
    • Monoclonal antibodies against the human metalloprotease EC 3.4.24.15 label neurofibrillary tangles in Alzheimer's disease brain
    • Conn K.J., Pietropaolo M., Ju S.-T., Abraham C.R. Monoclonal antibodies against the human metalloprotease EC 3.4.24.15 label neurofibrillary tangles in Alzheimer's disease brain. J. Neurochem. 66:1996;2011-2018.
    • (1996) J. Neurochem. , vol.66 , pp. 2011-2018
    • Conn, K.J.1    Pietropaolo, M.2    Ju, S.-T.3    Abraham, C.R.4
  • 7
    • 0342318219 scopus 로고    scopus 로고
    • Amyloidin protease and uses thereof, US Patent 5,424,205 (1995)
    • Dovey, H.F., Seubert, P.A. and Sinha, S., Amyloidin protease and uses thereof, US Patent 5,424,205 (1995).
    • Dovey, H.F.1    Seubert, P.A.2    Sinha, S.3
  • 10
  • 16
    • 0028277270 scopus 로고
    • Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-β By cathepsin D
    • Ladror U.S., Snyder S.W., Wang G.T., Holzman T.F., Krafft G.A. Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-β by cathepsin D. J. Biol. Chem. 269:1994;18422-18428.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18422-18428
    • Ladror, U.S.1    Snyder, S.W.2    Wang, G.T.3    Holzman, T.F.4    Krafft, G.A.5
  • 18
    • 0016668570 scopus 로고
    • Changes in proteolytic enzymes and proteins during maturation of the brain
    • Marks N., Stern F., Lajla A. Changes in proteolytic enzymes and proteins during maturation of the brain. Brain Res. 86:1975;307-322.
    • (1975) Brain Res. , vol.86 , pp. 307-322
    • Marks, N.1    Stern, F.2    Lajla, A.3
  • 19
    • 0026769423 scopus 로고
    • Human brain peptidase activity with the specificity to generate the N-terminus of the Alzheimer β-amyloid protein from its precursor
    • McDermott J.R., Biggins J.A., Gibson A.M. Human brain peptidase activity with the specificity to generate the N-terminus of the Alzheimer β-amyloid protein from its precursor. Biochem. Biophys. Res. Commun. 185:1992;746-752.
    • (1992) Biochem. Biophys. Res. Commun. , vol.185 , pp. 746-752
    • McDermott, J.R.1    Biggins, J.A.2    Gibson, A.M.3
  • 21
    • 0028040302 scopus 로고
    • Identification of a metalloprotease from Alzheimer's disease brain able to degrade the β-amyloid precursor protein and generate amyloidogenic fragments
    • Papastoitsis G., Siman R., Scott R., Abraham C.R. Identification of a metalloprotease from Alzheimer's disease brain able to degrade the β-amyloid precursor protein and generate amyloidogenic fragments. Biochemistry. 33:1994;192-199.
    • (1994) Biochemistry , vol.33 , pp. 192-199
    • Papastoitsis, G.1    Siman, R.2    Scott, R.3    Abraham, C.R.4
  • 22
    • 0026674462 scopus 로고
    • A calcium-stimulated serine protease from monkey brain degrades the β-amyloid precursor protein
    • Razzaboni B.L., Papastoitsis G., Koo E.H., Abraham C.R. A calcium-stimulated serine protease from monkey brain degrades the β-amyloid precursor protein. Brain Res. 589:1992;207-216.
    • (1992) Brain Res. , vol.589 , pp. 207-216
    • Razzaboni, B.L.1    Papastoitsis, G.2    Koo, E.H.3    Abraham, C.R.4
  • 23
    • 0029970783 scopus 로고    scopus 로고
    • Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D
    • Saftig P., Peters C., Von Figura K., Craessaerts K., Van Leuven F., De Strooper B. Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. J. Biol. Chem. 271:1996;27241-27244.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27241-27244
    • Saftig, P.1    Peters, C.2    Von Figura, K.3    Craessaerts, K.4    Van Leuven, F.5    De Strooper, B.6
  • 24
    • 0028236347 scopus 로고
    • Purification and characterization of a novel metalloprotease from human brain with the ability to cleave substrates derived from the N-terminus of β-amyloid protein
    • Schönlein C., Löffler J., Huber G. Purification and characterization of a novel metalloprotease from human brain with the ability to cleave substrates derived from the N-terminus of β-amyloid protein. Biochem. Biophys. Res. Commun. 201:1994;45-53.
    • (1994) Biochem. Biophys. Res. Commun. , vol.201 , pp. 45-53
    • Schönlein, C.1    Löffler, J.2    Huber, G.3
  • 25
    • 0028812394 scopus 로고
    • Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease
    • Schwagerl A.L., Mohan P.S., Cataldo A.M., Vonsattel J.P., Kowall N.W., Nixon R.A. Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease. J. Neurochem. 64:1995;443-446.
    • (1995) J. Neurochem. , vol.64 , pp. 443-446
    • Schwagerl, A.L.1    Mohan, P.S.2    Cataldo, A.M.3    Vonsattel, J.P.4    Kowall, N.W.5    Nixon, R.A.6
  • 26
    • 0028267440 scopus 로고
    • Normal and abnormal biology of the β-amyloid precursor protein
    • Selkoe D.J. Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci. 17:1994;489-517.
    • (1994) Annu. Rev. Neurosci. , vol.17 , pp. 489-517
    • Selkoe, D.J.1
  • 28
    • 0029163006 scopus 로고
    • Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a β-APP substrate peptide
    • Thompson A., Huber G., Malherbe P. Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a β-APP substrate peptide. Biochem. Biophys. Res. Commun. 213:1995;66-73.
    • (1995) Biochem. Biophys. Res. Commun. , vol.213 , pp. 66-73
    • Thompson, A.1    Huber, G.2    Malherbe, P.3
  • 29
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • Yankner B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 16:1996;921-932.
    • (1996) Neuron , vol.16 , pp. 921-932
    • Yankner, B.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.