Differential gonadotropin-releasing hormone stimulation of rat luteinizing hormone subunit gene transcription by calcium influx and mitogen-activated protein kinase-signaling pathways

Molecular Endocrinology

Volumn 12, Issue 3, 1998, Pages 451-457

  Weck, J ^a   Fallest, P C ^a   Pitt, L K ^a   Shupnik, M A ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALCIUM ION; GONADORELIN; MITOGEN ACTIVATED PROTEIN KINASE; NIMODIPINE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GONADOTROPIN RELEASE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0032230357     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.3.0070     Document Type: Article

References (52)

1. Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone
2. The physiology of gonadotropin-releasing hormone (GnRH) in men and women
3. Gonadotropin-releasing hormone pulses: Regulators of gonadotropin synthesis and ovulatory cycles
4. Luteinizing hormone-releasing hormone release during the rat estrous cycle and after ovariectory as estimated with push-pull cannulae
5. A pulsatile gonadotropin-releasing hormone stimulus is required to increase transcription of the gonadotropin subunit genes: Evidence for differential regulation of transcription by pulse frequency in vivo
6. Effects of gonadotropin-releasing hormone on rat gonadotropin gene transcription in vitro: Requirement for pulsatile administration for luteinizing hormone-β gene stimulation
7. Gonadotrope- and thyrotrope-specific expression of the human and bovine glycoprotein hormone α-subunit genes is regulated by distinct cis-acting elements
8. Analysis of DNA sequences required for pituitary-specific expression of the glycoprotein hormone alpha-subunit gene
9. Tissue-specific gene expression in the pituitary: The glycoprotein hormone alpha-subunit gene is regulated by a gonadotropin-specific protein
10. Identification of a gonadotropin-releasing hormone-responsive region in the glycoprotein hormone α-subunit promoter
11. Two different DNA elements mediate gonadotropin releasing hormone effects on expression of the glycoprotein hormone α-subunit gene
12. The gene encoding the β-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence
13. DNA sequence required for expression of the LHβ promoter in primary cultures of rat pituitary cells
14. Expression of luteinising hormone-β subunit chloramphenicol acetyltransferase (LH-β-CAT) fusion gene in rat pituitary cells: Induction by cyclic 3'-adenosine monophosphate (cAMP)
15. Regulation of rat luteinizing hormone beta gene expression in transgenic mice by steroids and a gonadotropin-releasing hormone antagonist
16. The proximal promoter of the bovine luteinzing hormone β-subunit gene confers gonadotrope-specific expression and regulation by gonadotropin-releasing hormone, testosterone, and 17β-estradiol in transgenic mice
17. Stimulation of rat luteinizing hormone-β messenger RNA levels by gonadotropin releasing hormone: Apparent role for protein kinase C
18. 2+ and protein kinase C
19. Intracellular responses to gonadotropin-releasing hormone in a clonal cell line of gonadotrope lineage
20. Studies of gonadotropin-releasing hormone (GnRH) action using GnRH-receptor expressing cell lines
21. Calcium signaling and secretory responses in agonist-stimulated pituitary gonadotropes
22. Gonadotropin-releasing hormone-induced calcium signaling in clonal pituitary gonadotrophs
23. Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphospate-binding proteins Gq and G11
24. The gonadotropin-releasing hormone receptor of alphaT3-1 pituitary cells regulates cellular levels of both of the phosphoinositide C-linked proteins, Gq alpha and G11 alpha, equally
25. A role for mitogen-activated protein kinase in mediating activation of the glycoprotein hormone α-subunit promoter by gonadotropin-releasing hormone
26. Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone: Evidence for the involvement of protein kinase C
27. Gonadotropin-releasing hormone causes transcriptional stimulation followed by desensitization of the glycoprotein hormone α promoter in transfected αT3 gonadotrope cells
28. The interaction of gonadotropin-releasing hormone and estradiol on luteinizing hormone and prolactin gene expression in female hypogonadal (hpg) mice
29. A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone
30. Down-regulation of the gonadotropin-releasing hormone receptor messenger ribonucleic acid by activation of adenylyl cyclase in αT3-1 pituitary gonadotrope cells
31. jun B promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2
32. The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades
33. Calcium and glycoprotein hormone α-subunit gene expression and secretion in αT3-1 gonadotropes
34. Regulation of glycoprotein hormone free α-subunit secretion and intracellular α-subunit content in primary pituitary cells
35. Stimulation of luteinizing hormone beta gene promoter by the orphan nuclear receptor steroidogenic factor-1
36. The nuclear receptor steroidogenic factor-1 is essential for the formation of the ventromedial hypothalamic nucleus
37. A steroidogenic factor-1 binding site is required for activity of the luteinizing hormone β-subunit promoter in gonadotropes of transgenic mice
38. Cholera toxin and dibutyryl cyclic adenosine 3', 5'-monophosphate sensitize gonadotropin-releasing hormone-stimulated inositol phosphate production to inhibition in protein kinase-C (PKC)-depleted cells: Evidence for cross-talk between a cholera toxin-sensitive G-protein and PKC
39. 2+-calmodulin dependent protein kinases type I, II, and IV
40. Gonadotropin-releasing hormone and pituitary adenylate cyclase-activating polypeptide affect levels of cyclic adenosine 3',5'-monophosphate-dependent protein kinase A (PKA) subunit in the clonal gonadotrope αT3-1 cells
41. 2+ oscillations
42. Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: Evidence for multiple guanyl nucleotide binding proteins in GnRH action
43. Type-specific regulation of adenylyl cyclase by G protein βγ subunits
44. Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C
45. ++ channels by G-protein βγ subunits
46. Interactions of thyrotropin-releasing hormone, phorbol ester, and forskolin-sensitive regions of the rat thyrotropin-beta gene
47. 2+ channels and protein kinase C
48. Divergent effects of estradiol on gonadotropin gene transcription in pituitary fragments
49. Isolation and characterization of the gene encoding the alpha subunit of the rat pituitary glycoprotein hormones
50. DNA sequencing with chain-terminating inhibitors
51. Bihormonal cells producing gonadotropes and prolactin in a rat pituitary tumor cell line
52. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo