Analysis of the κ light chain variable region in multiple myeloma

British Journal of Haematology

Volumn 94, Issue 2, 1996, Pages 306-317

  Kosmas, Christos ^a   Viniou, Nora Athina ^a   Stamatopoulos, Kostas ^a   Courtenay Luck, Nigel S ^b   Papadaki, Theodora ^c   Kollia, Panagoula ^a   Paterakis, George ^a   Anagnostou, Dimitra ^c   Yataganas, Xenophon ^a   Loukopoulos, Dimitris ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c EVANGELISMOS HOSPITAL   (Greece)

Author keywords

immunoglobulin; light chain genes; multiple myeloma; somatic hypermutation

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN; GENOMIC DNA; IMMUNOGLOBULIN KAPPA CHAIN;

ARTICLE; CLINICAL ARTICLE; GENE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MULTIPLE MYELOMA; MYELOMA CELL; PRIORITY JOURNAL; SOMATIC MUTATION; BONE MARROW; CONTROLLED STUDY; GENE AMPLIFICATION; GENE INSERTION; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN TISSUE; MOLECULAR CLONING; OPEN READING FRAME; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; VKAPPA GENE;

EID: 8944234852     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1815.x     Document Type: Article

References (42)

1. Andris, J.S., Ehrlich, P.H., Ostberg, L. & Capra, J.D. (1992) Probing the human antibody repertoire to exogenous antigens. Journal of Immunology, 149, 4055-4059.
2. Bahler, D.W. & Levy, R. (1992) Clonal evolution of a follicular lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 89, 6770-6774.
3. Bakkus, M.H., Heirman, C., Van Riet, I., Van Camp, B. & Thielemans, K. (1992) Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutation. Blood, 80, 2326-2335.
4. Bakkus, M.H.C., Van Riet, I., Van Camp, B. & Thielemans, K. (1994) Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell. British Journal of Haematology, 87, 68-74.
5. Berek, C. & Milstein, C. (1987) Mutation drift and repertoire shift in the maturation of the immune response. Immunological Reviews, 96, 23-41.
6. Betz, A.G., Rada, C., Pannell, R., Milstein, C. & Neuberger, M.S. (1993) Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proceedings of the National Academy of Sciences of the United States of America, 90, 2385-2388.
7. Billadeau, D., Ahman, G., Greipp, P. & Van Ness, B. (1993) The bone marrow of multiple myeloma patients contains B-cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. Journal of Experimental Medicine, 178, 1023-1031.
8. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidium-phenol-chloroform extraction. Analytical Biochemistry, 162, 156-159.
9. Chuchana, P., Blancer, A., Brockly, F., Alexandre, D., Lefranc, G. & Lefranc, M.P. (1990) Definition of the human immunoglobulin variable lambda gene subgroups. European Journal of Immunology, 20, 1317-1325.
10. Cogné, M. & Guglielmi, P. (1993) Exon skipping without splice site mutation accounting for abnormal immunoglobulin chains in nonsecretory human myeloma. European Journal of Immunology, 23, 1289-1293.
11. Dono, M., Hashimoto, S., Fais, F., Trejo, V., Allen, S.L., Lichtman, S.M., Schulman, P., Vinciguerra, V.P., Sellars, B., Gregersen, P.K., Ferrarini, M. & Chiorazzi, N. (1996) Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification. Blood, 87, 1586-1594.
12. Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Müller, W. & Rajewsky, K. (1993) Immunoglobulin heavy and light chain genes rearrange independently at early stages of B-cell development. Cell, 72, 695-704.
13. French, D.L., Laskov, R. & Scharff, M.D. (1989) The role of somatic hypermutation in the generation of antibody diversity. Science, 244, 1152-1157.
14. Hieter, P.A., Korsmeyer, S.J., Waldmann, T.A. & Leder, P. (1981) Human immunoglobulin k light chain genes are deleted or rearranged in λ-producing B cells. Nature, 294, 368-372.
15. Kabat, E.A., Wu, T.T., Perry, H.M., Gottesman, K.S. & Foeller, C. (1991) Sequences of proteins of immunological interest. US Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, Md.
16. Kipps, T.J. & Carson, D.A. (1993) Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases. Blood, 81, 2475-2487.
17. Klein, R., Jaenichen, R. & Zachau, H.G. (1993) Expressed human immunoglobulin k genes and their hypermulation. European Journal of Immunology, 23, 3248-3271.
18. Korsmeyer, S.J., Hieter, P.A., Ravetch, J.V., Poplack, D.G., Waldmann. T.A. & Leder, P. (1981) Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proceedings of the National Academy of Sciences of the United States of America, 78, 7096-7100.
19. Kubagawa, H., Vogler, L,B., Capra, J.D., Conrad, M.E., Lawton, A.R. & Cooper, M.D. (1979) Studies on the clonal origin of multiple myeloma: use of individually specific (idiotype) antibodies to trace the ontogenic event to its earliest point of expression in B-cell differentiation. Journal of Experimental Medicine, 150, 792-807.
20. Kwok, S. & Higuchi, R. (1989) Avoiding false positives with PCR. Nature, 339, 237-238.
21. Levy, R., Levy, S., Cleary, M.L., Carroll, W.K., Bird, J. & Sklar, J. (1987) Somatic mutation in human B-cell tumors. Immunological Reviews, 96, 43-60.
22. - B-cell chronic lymphocytic leukemia. Blood, 86, 3883-3890.
23. Marks, J.D., Hoogenboom, H.R., Bonnert, T.P., McCafferty, J., Griffiths, A.D. & Winter, G. (1991) By-passing immunization: human antibodies from V-gene libraries displayed on phage. Journal of Molecular Biology, 222, 581-597.
24. Martin, T., Duffy, S.F., Carson, D.A. & Kipps, T.J. (1992) Evidence of somatic selection of natural autoantibodies. Journal of Experimental Medicine, 175, 983-991.
25. Pauza, M.E., Rehmann, J.A. & LeBien, T.W. (1993) Unusual patterns of immunoglobulin gene rearrangement and expression during human B-cell ontogeny: human B-cells can simultaneously express cell surface k and λ light chains. Journal of Experimental Medicine, 178. 139-149.
26. Rassenti, L.Z., Pratt, L.F., Chen, P.P., Carson, D.A. & Kipps, T.J. (1991) Autoantibody-encoding k L chain genes frequently rearranged in λ L chain-expressing chronic lymphocytic leukemia, Journal of Immunology, 147, 1060-1066.
27. Reth, M., Petrac, E., Wiese, P., Lobel, L. & Alt, F.W. (1987) Activation of VK gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. EMBO Journal, 6, 3299-3505.
28. Sahota, S., Hamblin, T., Oscier, D.G. & Stevenson, F.K. (1994) Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma. Leukemia, 8, 1285-1289.
29. Sambrook, J., Fritsch, E.F. & Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual. Cold Spring Harbor Laboratory, New York.
30. Sanger. F., Micklem, S. & Culson, A.R. (1977) DNA sequencing with chain terminating inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 74, 5463-5467.
31. Schatz, D.G., Oettinger, M.A. & Schlissel, M.S. (1992) V(D)J recombination: molecular biology and regulation. Annual Review of Immunology, 10, 359-383.
32. Shlomchik, M.J., Marshak-Rothstein, A., Wolfowitcz, C.B., Rothstein, T.L. & Weigert, M.G. (1987) The role of clonal selection and somatic mutation in autoimmunity. Nature, 328, 805-811.
33. Siekevitz, M., Kocks, C., Rajewsky, K. & Dildrop, R. (1987) Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses. Cell. 48, 757-770.
34. Siminovitch, K.A., Bakhshi, A., Goldman, P. & Korsmeyer, S.J. (1985) A uniform deleting element mediates the loss of kappa genes in human B cells. Nature, 316, 260-262.
35. Takemori, T & Rajewsky, K. (1981) Lambda chain expression at different stages of ontogeny in C57BL/6. BALB/c and SJL mice. European Journal of Immunology, 11, 618-625.
36. Tonegawa, S. (1983) Somatic generation of antibody diversity. Nature, 302, 575-581.
37. van Es, J.H., Gmelig Meyling, F.H.J. & Logtenberg, T. (1992) High frequency of somatically mutated IgM molecules in the human adult blood B-cell repertoire. European Journal of Immunology, 22. 2761-2764.
38. van Noesel, C.J.M. & van Lier, R.A.W. (1993) Architecture of the human B-cell antigen receptors. Blood, 82, 363-373.
39. Vescio, R.A., Cao, J., Hong, C.H., Lee, J.C., Wu, C.H., Der-Danielian. M., Wu, V., Newman, R., Lichtenstein, A.K. & Berenson, J.R. (1995) Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity. Journal of Immunology, 155, 2487-2497.
40. Wagner, S.D. & Luzzatto, L. (1993) Vκ gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the Vκ. locus and do not show somatic mutation. European Journal of Immunology, 23, 391-397.
41. Wagner, S.D., Martinelli, V. & Luzzatto, L. (1994) Similar patterns of Vκ gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia. Waldenström's macroglobulinemia, and myeloma. Blood, 83, 3647-3653.
42. Walter, M.A., Surti, U., Hofker, M.H. & Cox, D.W. (1990) The physical organization of the human immunoglobulin heavy chain gene. EMBO Journal, 9, 3303-3313.