메뉴 건너뛰기




Volumn 162, Issue , 1998, Pages 281-292

Somatic hypermutation of immunoglobulin variable region genes: Focus on follicular lymphoma and multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

EID: 0031897512     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1998.tb01448.x     Document Type: Review
Times cited : (38)

References (60)
  • 1
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity. Nature 1984;302:575-581.
    • (1984) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 3
    • 0022556211 scopus 로고
    • Antigen-driven selection of of virgin and memory B cells
    • MacLennan ICM, Gray D. Antigen-driven selection of of virgin and memory B cells. Immunol Rev 1986;91:61-85.
    • (1986) Immunol Rev , vol.91 , pp. 61-85
    • MacLennan, I.C.M.1    Gray, D.2
  • 4
    • 0028818503 scopus 로고
    • Somatic hypermutation: How many mechanisms diversify V region sequences
    • Maizels N. Somatic hypermutation: how many mechanisms diversify V region sequences. Cell 1995;83:9-12.
    • (1995) Cell , vol.83 , pp. 9-12
    • Maizels, N.1
  • 5
    • 0028151819 scopus 로고
    • Negative selection of lymphocytes
    • Nossal GJV. Negative selection of lymphocytes. Cell 1994;76:229-239.
    • (1994) Cell , vol.76 , pp. 229-239
    • Nossal, G.J.V.1
  • 6
    • 0027200965 scopus 로고
    • Architecture of the human B-cell antigen receptors
    • van Noesel CJM, van Lier RAW. Architecture of the human B-cell antigen receptors. Blood 1993;82:363-373.
    • (1993) Blood , vol.82 , pp. 363-373
    • Van Noesel, C.J.M.1    Van Lier, R.A.W.2
  • 7
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
    • Betz AG, Rada C, Pannell R, Milstein C, Neuberger MS. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci USA 1993;90:2385-2388.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2385-2388
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 8
    • 0027364313 scopus 로고
    • Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin κ light-chain transgenes
    • González-Fernández A, Milstein C. Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin κ light-chain transgenes. Proc Natl Acad Sci USA 1993;90:9862-9866.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9862-9866
    • González-Fernández, A.1    Milstein, C.2
  • 9
    • 0029067875 scopus 로고
    • Targeting of non-Ig sequences in places of the V-segment by somatic hypermutation
    • Yelamos J et al. Targeting of non-Ig sequences in places of the V-segment by somatic hypermutation. Nature 1995;376:225-229.
    • (1995) Nature , vol.376 , pp. 225-229
    • Yelamos, J.1
  • 10
    • 0027491651 scopus 로고
    • Tracing B cell development in human germinal centers by molecular analysis of single cells picked from histological sections
    • Küppers R, Zhao M, Hansmann M-L, Rajewsky K. Tracing B cell development in human germinal centers by molecular analysis of single cells picked from histological sections. EMBO J 1993;12:4955-4967.
    • (1993) EMBO J , vol.12 , pp. 4955-4967
    • Küppers, R.1    Zhao, M.2    Hansmann, M.-L.3    Rajewsky, K.4
  • 12
    • 0026636759 scopus 로고
    • Clonal evolution of a follicular lymphoma: Evidence for antigen selection
    • Bahler DW, Levy R. Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci USA 1992;89:6770-6774.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6770-6774
    • Bahler, D.W.1    Levy, R.2
  • 13
    • 0028341604 scopus 로고
    • Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes
    • Zhu D, Hawkins RE, Hamblin TJ, Stevenson FK. Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes. Br J Haematol 1994;86:505-512.
    • (1994) Br J Haematol , vol.86 , pp. 505-512
    • Zhu, D.1    Hawkins, R.E.2    Hamblin, T.J.3    Stevenson, F.K.4
  • 14
    • 0018721299 scopus 로고
    • Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the ontogenic event to its earliest point of expression in B-cell differentiation
    • Kubagawa H, Vogler LB, Capra JD, Conrad ME, Lawton AR, Cooper MD. Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the ontogenic event to its earliest point of expression in B-cell differentiation. J Exp Med 1979;150:792-807.
    • (1979) J Exp Med , vol.150 , pp. 792-807
    • Kubagawa, H.1    Vogler, L.B.2    Capra, J.D.3    Conrad, M.E.4    Lawton, A.R.5    Cooper, M.D.6
  • 15
    • 0026786675 scopus 로고
    • Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutation
    • Bakkus MH, Heirman C, Van Riet I, Van Camp B, Thielemans K. Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutation. Blood 1992;80:2326-2335.
    • (1992) Blood , vol.80 , pp. 2326-2335
    • Bakkus, M.H.1    Heirman, C.2    Van Riet, I.3    Van Camp, B.4    Thielemans, K.5
  • 16
    • 0029077309 scopus 로고
    • Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity
    • Vescio RA, et al. Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity. J Immunol 1995;155:2487-2497.
    • (1995) J Immunol , vol.155 , pp. 2487-2497
    • Vescio, R.A.1
  • 17
    • 0028178499 scopus 로고
    • Similar patterns of Vκ gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenström's macroglobulinemia, and myeloma
    • Wagner SD, Martinelli V, Luzzatto L. Similar patterns of Vκ gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenström's macroglobulinemia, and myeloma. Blood 1994;83:3647-3653.
    • (1994) Blood , vol.83 , pp. 3647-3653
    • Wagner, S.D.1    Martinelli, V.2    Luzzatto, L.3
  • 18
    • 8944234852 scopus 로고    scopus 로고
    • Analysis of κ light chain variable region in multiple myeloma
    • Kosmas C, et al. Analysis of κ light chain variable region in multiple myeloma. Br J Haematol 1996;94:306-317.
    • (1996) Br J Haematol , vol.94 , pp. 306-317
    • Kosmas, C.1
  • 19
    • 0030614775 scopus 로고    scopus 로고
    • H sequences reveal a complementary imprint of antigen selection in tumor cells
    • H sequences reveal a complementary imprint of antigen selection in tumor cells. Blood 1997;89:219-226.
    • (1997) Blood , vol.89 , pp. 219-226
    • Sahota, S.S.1    Leo, R.2    Hamblin, T.J.3    Stevenson, F.K.4
  • 22
    • 0031015724 scopus 로고    scopus 로고
    • Follicular lymphoma immunoglobulin κ light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains
    • Stamatopoulos K, et al. Follicular lymphoma immunoglobulin κ light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains. Br J Haematol 1997;96:132-146.
    • (1997) Br J Haematol , vol.96 , pp. 132-146
    • Stamatopoulos, K.1
  • 25
    • 0027475327 scopus 로고
    • Structure and physical map of 64 variable segments in the 3′ 0.8 megabase region of the human immunoglobulin heavy-chain locus
    • Matsuda F, et al. Structure and physical map of 64 variable segments in the 3′ 0.8 megabase region of the human immunoglobulin heavy-chain locus. Nat Genet 1993;3:88-94.
    • (1993) Nat Genet , vol.3 , pp. 88-94
    • Matsuda, F.1
  • 27
    • 0027932998 scopus 로고
    • H genes are inherently susceptible to amino acid replacement
    • H genes are inherently susceptible to amino acid replacement. Immunol Today 1994;15:367-373.
    • (1994) Immunol Today , vol.15 , pp. 367-373
    • Chang, B.1    Casali, P.2
  • 28
    • 0027428398 scopus 로고
    • Expressed human immunoglobulin κ genes and their hypermutation
    • Klein R, Jaenichen R, Zachau HG. Expressed human immunoglobulin κ genes and their hypermutation. Eur J Immunol 1993;23:3248-3271.
    • (1993) Eur J Immunol , vol.23 , pp. 3248-3271
    • Klein, R.1    Jaenichen, R.2    Zachau, H.G.3
  • 29
    • 0024475733 scopus 로고
    • H gene expression in chronic lymphocytic leukemia
    • H gene expression in chronic lymphocytic leukemia. Int Immunol 1989;1:362-366.
    • (1989) Int Immunol , vol.1 , pp. 362-366
    • Logtenberg, T.1
  • 30
    • 0026611386 scopus 로고
    • VH restriction among human cold agglutinins: The VH4-21 gene segment is required to encode anti-I and anti-i specificities
    • Pascual V, Victor K, Spellerberg M, Hamblin TJ, Stevenson FK, Capra JD. VH restriction among human cold agglutinins: the VH4-21 gene segment is required to encode anti-I and anti-i specificities. J Immunol 1992;149:2337-2344.
    • (1992) J Immunol , vol.149 , pp. 2337-2344
    • Pascual, V.1    Victor, K.2    Spellerberg, M.3    Hamblin, T.J.4    Stevenson, F.K.5    Capra, J.D.6
  • 31
    • 0027336661 scopus 로고
    • Immunoglobulin VH4 gene usage in B lymphoid leukaemias
    • Deane M, Baker BW Norton JD. Immunoglobulin VH4 gene usage in B lymphoid leukaemias. Br J Haematol 1993;84:242-249.
    • (1993) Br J Haematol , vol.84 , pp. 242-249
    • Deane, M.1    Baker, B.W.2    Norton, J.D.3
  • 32
    • 0028820580 scopus 로고
    • Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma
    • Hsu FJ, Levy R. Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma. Blood 1995;86:372-382.
    • (1995) Blood , vol.86 , pp. 372-382
    • Hsu, F.J.1    Levy, R.2
  • 34
    • 0029063311 scopus 로고
    • Analysis of the heavy chain repertoire of human peripheral B-cells using single-cell polymerase chain reaction
    • Brezinschek HP, Brezinschek RI, Lipsky PE. Analysis of the heavy chain repertoire of human peripheral B-cells using single-cell polymerase chain reaction. J Immunol 1995;155:190-202.
    • (1995) J Immunol , vol.155 , pp. 190-202
    • Brezinschek, H.P.1    Brezinschek, R.I.2    Lipsky, P.E.3
  • 35
    • 0026099589 scopus 로고
    • Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes
    • Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera G. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med 1991;173:395-407.
    • (1991) J Exp Med , vol.173 , pp. 395-407
    • Yamada, M.1    Wasserman, R.2    Reichard, B.A.3    Shane, S.4    Caton, A.J.5    Rovera, G.6
  • 36
    • 0023409210 scopus 로고
    • Increased frequency of N-regional insertion in a murine pre-B-cell line infected with a terminal deoxynudeotidyl transferase retroviral expression vector
    • Landau NR, Schatz DG, Rosa M, Baltimore D. Increased frequency of N-regional insertion in a murine pre-B-cell line infected with a terminal deoxynudeotidyl transferase retroviral expression vector. Mol Cell Biol 1987;7:3237-3243.
    • (1987) Mol Cell Biol , vol.7 , pp. 3237-3243
    • Landau, N.R.1    Schatz, D.G.2    Rosa, M.3    Baltimore, D.4
  • 37
    • 0027476466 scopus 로고
    • Immunoglobulin heavy and light chain genes rearrange independently at early stages of B-cell development
    • Ehlich A, Schaal S, Gu H, Kitamura D, Müller W, Rajewsky K. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B-cell development. Cell 1993;72:695-704.
    • (1993) Cell , vol.72 , pp. 695-704
    • Ehlich, A.1    Schaal, S.2    Gu, H.3    Kitamura, D.4    Müller, W.5    Rajewsky, K.6
  • 38
    • 0026844401 scopus 로고
    • The development of B-cells and B-cell repertoire in the microenvironment of the germinal center
    • Berek C. The development of B-cells and B-cell repertoire in the microenvironment of the germinal center. Immunol Rev 1992;126:5-19.
    • (1992) Immunol Rev , vol.126 , pp. 5-19
    • Berek, C.1
  • 39
    • 0027157149 scopus 로고
    • Differential usage of an Ig heavy chain variable region gene by human B-cell tumors
    • Stevenson FK, et al. Differential usage of an Ig heavy chain variable region gene by human B-cell tumors. Blood 1993;82:224-230.
    • (1993) Blood , vol.82 , pp. 224-230
    • Stevenson, F.K.1
  • 40
    • 0012518336 scopus 로고
    • Non-Hodgkin's lymphomas
    • Lee GR, Bithell TV, Foerster J, Athens JW, Lukens JN, eds. Philadelphia: Lea and Febiger
    • Greer JP, Macon WR, List AF, McCurley TL. Non-Hodgkin's lymphomas. In: Lee GR, Bithell TV, Foerster J, Athens JW, Lukens JN, eds. Wintrobe's clinical hematology. 9th edition. Philadelphia: Lea and Febiger; 1993. p. 2082-2142.
    • (1993) Wintrobe's Clinical Hematology. 9th Edition , pp. 2082-2142
    • Greer, J.P.1    Macon, W.R.2    List, A.F.3    McCurley, T.L.4
  • 41
    • 0029952779 scopus 로고    scopus 로고
    • Hodgkin's and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
    • Kanzler H, Küppers R, Hansmann M-L, Rajewsky K. Hodgkin's and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 1996;184:1495-1505.
    • (1996) J Exp Med , vol.184 , pp. 1495-1505
    • Kanzler, H.1    Küppers, R.2    Hansmann, M.-L.3    Rajewsky, K.4
  • 42
    • 0030791751 scopus 로고    scopus 로고
    • Origin of nodular lymphocyte predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells
    • Marafioti T, et al. Origin of nodular lymphocyte predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells. N Engl J Med 1997;337:453-458.
    • (1997) N Engl J Med , vol.337 , pp. 453-458
    • Marafioti, T.1
  • 45
    • 0027201551 scopus 로고
    • Cloning and sequencing of human immunoglobulin Vλ gene segments
    • Williams SC, Winter G. Cloning and sequencing of human immunoglobulin Vλ gene segments. Eur J Immunol 1993;23:1456-1461.
    • (1993) Eur J Immunol , vol.23 , pp. 1456-1461
    • Williams, S.C.1    Winter, G.2
  • 46
    • 0028305298 scopus 로고
    • Variable κ gene rearrangement in lymphoproliferative disorders and analysis of Vκ gene usage, VJ joining and somatic mutation
    • Cannell PK, Amlot P, Attard M, Hoffbrand AV, Foroni L. Variable κ gene rearrangement in lymphoproliferative disorders and analysis of Vκ gene usage, VJ joining and somatic mutation. Leukemia 1994;8:1139-1145.
    • (1994) Leukemia , vol.8 , pp. 1139-1145
    • Cannell, P.K.1    Amlot, P.2    Attard, M.3    Hoffbrand, A.V.4    Foroni, L.5
  • 47
    • 0025167382 scopus 로고
    • H, Vκ, Vλ) expressed in early fetal bone marrow
    • H, Vκ, Vλ) expressed in early fetal bone marrow. New Biologist 1990;2:689-699.
    • (1990) New Biologist , vol.2 , pp. 689-699
    • Cuisinier, A.M.1
  • 48
    • 0027257608 scopus 로고
    • The bone marrow of multiple myeloma patients contains B-cell populations at different stages of differentiation that are clonally related to the malignant plasma cell
    • Billadeau D, Ahman G, Greipp P, Van Ness B. The bone marrow of multiple myeloma patients contains B-cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. J Exp Med 1993;178:1023-1031.
    • (1993) J Exp Med , vol.178 , pp. 1023-1031
    • Billadeau, D.1    Ahman, G.2    Greipp, P.3    Van Ness, B.4
  • 49
    • 0028246112 scopus 로고
    • Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell
    • Bakkus MHC, Van Riet I, Van Camp B, Thielemans K. Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell. Br J Haematol 1994;87:68-74.
    • (1994) Br J Haematol , vol.87 , pp. 68-74
    • Bakkus, M.H.C.1    Van Riet, I.2    Van Camp, B.3    Thielemans, K.4
  • 50
    • 0027991864 scopus 로고
    • Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma
    • Sahota S, Hamblin T, Oscier DG, Stevenson FK. Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma. Leukemia 1994;8:1285-1289.
    • (1994) Leukemia , vol.8 , pp. 1285-1289
    • Sahota, S.1    Hamblin, T.2    Oscier, D.G.3    Stevenson, F.K.4
  • 51
    • 0027497795 scopus 로고
    • Vκ gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the Vκ locus and do not show somatic mutation
    • Wagner SD, Luzzatto L. Vκ gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the Vκ locus and do not show somatic mutation. Eur J Immunol 1993;23:391-397.
    • (1993) Eur J Immunol , vol.23 , pp. 391-397
    • Wagner, S.D.1    Luzzatto, L.2
  • 52
    • 0025812066 scopus 로고
    • Autoantibody-encoding λ L chain genes frequently rearranged in λ L chain-expressing chronic lymphocytic leukemia
    • Rassenti LZ, Pratt LF, Chen PP, Carson DA, Kipps TJ. Autoantibody-encoding λ L chain genes frequently rearranged in λ L chain-expressing chronic lymphocytic leukemia. J Immunol 1991;147:1060-1066.
    • (1991) J Immunol , vol.147 , pp. 1060-1066
    • Rassenti, L.Z.1    Pratt, L.F.2    Chen, P.P.3    Carson, D.A.4    Kipps, T.J.5
  • 53
    • 0019455850 scopus 로고
    • Human immunoglobulin κ light chain genes are deleted or rearranged in λ-producing B cells
    • Hieter PA, Korsmeyer SJ, Waldmann TA. Leder P. Human immunoglobulin κ light chain genes are deleted or rearranged in λ-producing B cells. Nature 1981;294:368-372.
    • (1981) Nature , vol.294 , pp. 368-372
    • Hieter, P.A.1    Korsmeyer, S.J.2    Waldmann, T.A.3    Leder, P.4
  • 54
    • 0021870867 scopus 로고
    • A uniform deleting element mediates the loss of kappa genes in human B cells
    • Siminovitch KA, Bakhshi A, Goldman P, Korsmeyer SJ. A uniform deleting element mediates the loss of kappa genes in human B cells. Nature 1985;316:260-262.
    • (1985) Nature , vol.316 , pp. 260-262
    • Siminovitch, K.A.1    Bakhshi, A.2    Goldman, P.3    Korsmeyer, S.J.4
  • 55
    • 0026768775 scopus 로고
    • Clonal expansion in follicular lymphoma occurs subsequently to antigenic selection
    • Zelenetz AD, Chen TT, Levy R. Clonal expansion in follicular lymphoma occurs subsequently to antigenic selection. J Exp Med 1992;176:1137-1148.
    • (1992) J Exp Med , vol.176 , pp. 1137-1148
    • Zelenetz, A.D.1    Chen, T.T.2    Levy, R.3
  • 57
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996;381:751-758.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 58
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • Berek C, Milstein C. Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev 1987;96:23-41.
    • (1987) Immunol Rev , vol.96 , pp. 23-41
    • Berek, C.1    Milstein, C.2
  • 59
    • 0026331458 scopus 로고
    • Maturation of immune responses in germinal centers
    • Berek C, Berger A, Apel M. Maturation of immune responses in germinal centers. Cell 1991;67:1121-1129.
    • (1991) Cell , vol.67 , pp. 1121-1129
    • Berek, C.1    Berger, A.2    Apel, M.3
  • 60
    • 0023652377 scopus 로고
    • Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses
    • Siekevitz M, Kocks C, Rajewsky K, Dildrop R. Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses. Cell 1987;48:757-770.
    • (1987) Cell , vol.48 , pp. 757-770
    • Siekevitz, M.1    Kocks, C.2    Rajewsky, K.3    Dildrop, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.