-
1
-
-
0026425587
-
Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models
-
AKINAGA, S., GOMI, K., MOTIMOTO, M., TAMAOKI, T. and OKABE, M., Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models. Cancer Res., 51, 4888-4892 (1991).
-
(1991)
Cancer Res.
, vol.51
, pp. 4888-4892
-
-
Akinaga, S.1
Gomi, K.2
Motimoto, M.3
Tamaoki, T.4
Okabe, M.5
-
2
-
-
0027936679
-
Expression and biochemical characterization of human protein kinase C-theta
-
BAIER, G., BAIER-BITTERLICH, G., MELLER, N., COGGESHALL, K.M., GIAMPA, L., TELFORD, D., ISAKOV, N. and ALTMAN, A., Expression and biochemical characterization of human protein kinase C-theta. Europ. J. Biochem., 225, 195-203 (1994).
-
(1994)
Europ. J. Biochem.
, vol.225
, pp. 195-203
-
-
Baier, G.1
Baier-Bitterlich, G.2
Meller, N.3
Coggeshall, K.M.4
Giampa, L.5
Telford, D.6
Isakov, N.7
Altman, A.8
-
3
-
-
0029861463
-
The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-jun expression, and activates jun N-terminal kinase
-
BELTMAN, J., MCCORMICK, F. and COOK, S.J., The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-jun expression, and activates jun N-terminal kinase. J. biol. Chem., 271, 27018-27024 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 27018-27024
-
-
Beltman, J.1
Mccormick, F.2
Cook, S.J.3
-
4
-
-
0027439693
-
Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC-α
-
BLOBE, G.C., SACHS, C.W., KHAN, W.A., FABBRO, D., STABEL, S., WETSEL, W.C., OBEID, L.M., FINE, R.L. and HANNUN, Y.A., Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC-α. J. biol. Chem., 268, 658-664 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 658-664
-
-
Blobe, G.C.1
Sachs, C.W.2
Khan, W.A.3
Fabbro, D.4
Stabel, S.5
Wetsel, W.C.6
Obeid, L.M.7
Fine, R.L.8
Hannun, Y.A.9
-
5
-
-
0009484240
-
PKC and cellular transformation
-
D.S. Lester and R. Epand (eds.), Ellis Horwood, Chichester
-
BORNER, C. and FABBRO, D., PKC and cellular transformation. In: D.S. Lester and R. Epand (eds.), Protein kinase C - current concepts and future perspectives, pp. 297-354, Ellis Horwood, Chichester (1992).
-
(1992)
Protein Kinase C - Current Concepts and Future Perspectives
, pp. 297-354
-
-
Borner, C.1
Fabbro, D.2
-
6
-
-
0028815491
-
Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts
-
BORNER, C., UEFFING, M., JAKEN, S., PARKER, P.J. and WEINSTEIN, I.B., Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. J. biol. Chem., 270, 78-86 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 78-86
-
-
Borner, C.1
Ueffing, M.2
Jaken, S.3
Parker, P.J.4
Weinstein, I.B.5
-
7
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding
-
BRADFORD, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem., 72, 248-254 (1976).
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
8
-
-
0040761368
-
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
-
BÜCHLER, M., KÖNIG, J., BROM, M., KARTENBECK, J., SPRING, H., HORIES, T. and KEPPLER, D., cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. biol. Chem., 271, 15091-15098 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 15091-15098
-
-
Büchler, M.1
König, J.2
Brom, M.3
Kartenbeck, J.4
Spring, H.5
Hories, T.6
Keppler, D.7
-
9
-
-
0029988743
-
Comparison of staurosporine and four analogues: Their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells
-
BUDWORTH, J., DAVIES, R., MALKHANDI, J., GANT, T.W., FEFFY, D.R. and GESCHER, A., Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells. Brit. J. Cancer, 73, 1063-1068 (1996).
-
(1996)
Brit. J. Cancer
, vol.73
, pp. 1063-1068
-
-
Budworth, J.1
Davies, R.2
Malkhandi, J.3
Gant, T.W.4
Feffy, D.R.5
Gescher, A.6
-
10
-
-
0027182090
-
The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts
-
CACACE, A.M., GUADAGNO, S.N., KRAUSS, R.S., FABBRO, D. and WEINSTEIN, I.B., The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene, 8, 2095-2104 (1993).
-
(1993)
Oncogene
, vol.8
, pp. 2095-2104
-
-
Cacace, A.M.1
Guadagno, S.N.2
Krauss, R.S.3
Fabbro, D.4
Weinstein, I.B.5
-
11
-
-
0027506202
-
Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs
-
CHAUDHARY, P.M. and RONINSON, I.B., Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J. nat. Cancer Inst., 85, 632-639 (1993).
-
(1993)
J. Nat. Cancer Inst.
, vol.85
, pp. 632-639
-
-
Chaudhary, P.M.1
Roninson, I.B.2
-
12
-
-
0028953612
-
Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation
-
COURAGE, C., BUDWORTH, J. and GESCHER, A., Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation. Brit. J. Cancer, 71, 697-704 (1995).
-
(1995)
Brit. J. Cancer
, vol.71
, pp. 697-704
-
-
Courage, C.1
Budworth, J.2
Gescher, A.3
-
13
-
-
0024324487
-
Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells
-
DALE, I.L., BRADSHAW, T.D., GESCHER, A. and PETTIT, G.R., Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells. Cancer Res., 49, 3242-3245 (1989).
-
(1989)
Cancer Res.
, vol.49
, pp. 3242-3245
-
-
Dale, I.L.1
Bradshaw, T.D.2
Gescher, A.3
Pettit, G.R.4
-
14
-
-
0026538078
-
Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity
-
DAVIS, P.D., ELLIOTT, L., HAEEIS, W., HURST, S.A., KEECH, E., KUMAR, H., LAWTON, G., NIXON, J.S. and WILKINSON, S.E., Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity. J. med. Chem., 35, 994-1001 (1992).
-
(1992)
J. Med. Chem.
, vol.35
, pp. 994-1001
-
-
Davis, P.D.1
Elliott, L.2
Haeeis, W.3
Hurst, S.A.4
Keech, E.5
Kumar, H.6
Lawton, G.7
Nixon, J.S.8
Wilkinson, S.E.9
-
15
-
-
8944231156
-
Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression
-
DEAN, N., MCKAY, R., MIRGLIA, L., HOWARD, R., COOPER, S., GIDDINGS, J., NICKLIN, P., MEISTER, L., ZIEL, R., GEIGER, T., MÜLLER, M. and FABBRO, D., Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression. Cancer Res., 56, 3499-3507 (1996).
-
(1996)
Cancer Res.
, vol.56
, pp. 3499-3507
-
-
Dean, N.1
Mckay, R.2
Mirglia, L.3
Howard, R.4
Cooper, S.5
Giddings, J.6
Nicklin, P.7
Meister, L.8
Ziel, R.9
Geiger, T.10
Müller, M.11
Fabbro, D.12
-
16
-
-
0025941535
-
Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro
-
DLUGOSZ, A.A. and YUSPA, S.H., Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro. Cancer Res., 51, 4677-4684 (1991).
-
(1991)
Cancer Res.
, vol.51
, pp. 4677-4684
-
-
Dlugosz, A.A.1
Yuspa, S.H.2
-
17
-
-
0028857378
-
The specific bisindolylmaleimide PKC-inhibitor GF 109203X efficiently modulates MRP-associated multiple drug resistance
-
GEKELER, V., BOER, R., ISE, W., SANDERS, K.H., SCHÄCHTELE, C. and BECK, J., The specific bisindolylmaleimide PKC-inhibitor GF 109203X efficiently modulates MRP-associated multiple drug resistance. Biochem. biophys. Res. Comm., 206, 119-126 (1995).
-
(1995)
Biochem. Biophys. Res. Comm.
, vol.206
, pp. 119-126
-
-
Gekeler, V.1
Boer, R.2
Ise, W.3
Sanders, K.H.4
Schächtele, C.5
Beck, J.6
-
18
-
-
0022374629
-
Characterization of the growth inhibition by tumour promoting phorbol esters and of their receptor binding in A549 human lung carcinoma cells
-
GESCHER, A. and REED, D.J., Characterization of the growth inhibition by tumour promoting phorbol esters and of their receptor binding in A549 human lung carcinoma cells. Cancer Res., 45, 4325-4329 (1985).
-
(1985)
Cancer Res.
, vol.45
, pp. 4325-4329
-
-
Gescher, A.1
Reed, D.J.2
-
19
-
-
0026515851
-
Protein kinase C isoforms in multidrug resistant P388/ADR cells: A possible role in daunorubicin transport
-
GOLLAPUDI, S., PATEL, K., JAIN, V. and GUPTA, S., Protein kinase C isoforms in multidrug resistant P388/ADR cells: a possible role in daunorubicin transport. Cancer Lett., 62, 69-75 (1992).
-
(1992)
Cancer Lett.
, vol.62
, pp. 69-75
-
-
Gollapudi, S.1
Patel, K.2
Jain, V.3
Gupta, S.4
-
21
-
-
0026563893
-
The protein kinase C related PKC-L (η) gene product is localized in the cell nucleus
-
GREIF, H., BEN-CHAIM, J., SHIMON, T., BECHOR, E., ELDAR, H. and LIVNEH, E., The protein kinase C related PKC-L (η) gene product is localized in the cell nucleus. Mol. cell. Biochem., 12, 1304-1311 (1992).
-
(1992)
Mol. Cell. Biochem.
, vol.12
, pp. 1304-1311
-
-
Greif, H.1
Ben-Chaim, J.2
Shimon, T.3
Bechor, E.4
Eldar, H.5
Livneh, E.6
-
22
-
-
0029965696
-
Protein kinase C isozymes and substrates
-
JAKEN, S., Protein kinase C isozymes and substrates. Curr. Opin. Cell. Biol., 8, 168-173 (1996).
-
(1996)
Curr. Opin. Cell. Biol.
, vol.8
, pp. 168-173
-
-
Jaken, S.1
-
23
-
-
0030872696
-
Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analogues
-
JONES, T., COURAGE, C. HUBBARD, A. and GESCHER, A., Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analogues. Biochem. Pharmacol. 53, 1413-1418 (1997).
-
(1997)
Biochem. Pharmacol.
, vol.53
, pp. 1413-1418
-
-
Jones, T.1
Courage, C.2
Hubbard, A.3
Gescher, A.4
-
24
-
-
0029871688
-
UCN-01, 7-hydroxystaurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line
-
KAWAKAMI, K., FUTAMI, H., TAKAHARA, J. and YAMAGUCHI, K., UCN-01, 7-hydroxystaurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line. Biochem. biophys. Res. Comm., 219, 778-783 (1996).
-
(1996)
Biochem. Biophys. Res. Comm.
, vol.219
, pp. 778-783
-
-
Kawakami, K.1
Futami, H.2
Takahara, J.3
Yamaguchi, K.4
-
25
-
-
0026448386
-
Selective redistribution of protein kinase C isoenzyme by thapsigargin and staurosporine
-
KILEY, S.C., PARKER, P.J., FABBRO, D. and JAKEN, S., Selective redistribution of protein kinase C isoenzyme by thapsigargin and staurosporine. Carcinogenesis, 13, 1997-2001 (1992).
-
(1992)
Carcinogenesis
, vol.13
, pp. 1997-2001
-
-
Kiley, S.C.1
Parker, P.J.2
Fabbro, D.3
Jaken, S.4
-
26
-
-
0024379951
-
A derivative of staurosporine (CGP 41251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vitro antitumour activity
-
MEYER, T., REGENASS, U., FABBRO, D., ALTERI, E., RÖSEL, J., MÜLLER, M., CARAVATTI, G. and MATTER, A., A derivative of staurosporine (CGP 41251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vitro antitumour activity. Int. J. Cancer, 43, 851-856 (1989).
-
(1989)
Int. J. Cancer
, vol.43
, pp. 851-856
-
-
Meyer, T.1
Regenass, U.2
Fabbro, D.3
Alteri, E.4
Rösel, J.5
Müller, M.6
Caravatti, G.7
Matter, A.8
-
27
-
-
0026451081
-
Intracellular signaling by hydrolysis of phospholipids and activation of PKC
-
NISHIZUKA, Y., Intracellular signaling by hydrolysis of phospholipids and activation of PKC. Science, 258, 607-614 (1992).
-
(1992)
Science
, vol.258
, pp. 607-614
-
-
Nishizuka, Y.1
-
28
-
-
0024797181
-
Human multidrug resistant KB cells overexpress PKC: Involvement in drug resistance
-
POSADA, J., MCKEEGAN, E., WORTHINGTON, K., MORIN, M., JAKEN, S. and TRITTON, T., Human multidrug resistant KB cells overexpress PKC: involvement in drug resistance. Cancer Comm., 1, 285-292 (1989).
-
(1989)
Cancer Comm.
, vol.1
, pp. 285-292
-
-
Posada, J.1
Mckeegan, E.2
Worthington, K.3
Morin, M.4
Jaken, S.5
Tritton, T.6
-
29
-
-
0028306807
-
Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue
-
SEYNAEVE, C.M., KAZANIETZ, M.G., BLUMBERG, P.M., SAUSVILLE, E.A. and WORLAND, P.J., Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Mol. Pharmacol., 45, 1207-1214 (1994).
-
(1994)
Mol. Pharmacol.
, vol.45
, pp. 1207-1214
-
-
Seynaeve, C.M.1
Kazanietz, M.G.2
Blumberg, P.M.3
Sausville, E.A.4
Worland, P.J.5
-
30
-
-
0030013883
-
Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via activation of protein kinase C
-
STANWELL, C., DLUGOSZ, A.A. and YUSPA, S.H., Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via activation of protein kinase C. Carcinogenesis, 17, 1259-1265 (1996).
-
(1996)
Carcinogenesis
, vol.17
, pp. 1259-1265
-
-
Stanwell, C.1
Dlugosz, A.A.2
Yuspa, S.H.3
-
31
-
-
0028205593
-
The role of protein kinase C isoenzymes in growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells
-
STANWELL, C., GESCHER, A., BRADSHAW, T.D. and PETTIT, G.R., The role of protein kinase C isoenzymes in growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells. Int. J. Cancer, 56, 585-592 (1994).
-
(1994)
Int. J. Cancer
, vol.56
, pp. 585-592
-
-
Stanwell, C.1
Gescher, A.2
Bradshaw, T.D.3
Pettit, G.R.4
-
32
-
-
0023552288
-
UCN-01, a selective inhibitor of protein kinase C from streptomyces
-
TAKAHASHI, I., KOHAYASHI, E., ASANO, K., YOSHIDA, M. and NAKANO, H., UCN-01, a selective inhibitor of protein kinase C from streptomyces. J. Antibiot., 40, 1782-1784 (1987).
-
(1987)
J. Antibiot.
, vol.40
, pp. 1782-1784
-
-
Takahashi, I.1
Kohayashi, E.2
Asano, K.3
Yoshida, M.4
Nakano, H.5
-
33
-
-
11944264245
-
Potent and specific inhibitors of protein kinase C of microbial origin
-
TAMAOKI, T. and NAKANO, H., Potent and specific inhibitors of protein kinase C of microbial origin. Biotechnology, 8, 732-735 (1990).
-
(1990)
Biotechnology
, vol.8
, pp. 732-735
-
-
Tamaoki, T.1
Nakano, H.2
-
34
-
-
0028231242
-
The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance
-
UTZ, I., HOFER, S., REGENASS, U., HILBE, W., THALER, W., GRÜNICKE, H. and HOFMANN, J., The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance. Int. J. Cancer, 57, 104-110 (1994).
-
(1994)
Int. J. Cancer
, vol.57
, pp. 104-110
-
-
Utz, I.1
Hofer, S.2
Regenass, U.3
Hilbe, W.4
Thaler, W.5
Grünicke, H.6
Hofmann, J.7
-
35
-
-
0028903545
-
MCF-7 breast cancer cells transfected with protein kinase C-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype
-
WAYS, D.K., KUKOLY, C.A., DEVENTE, Y., HOOKER, Y.L., BRANT, W.O., POSEKANY, J.K., FLETCHER, D.J., COOK, P.P. and PARKER, P.J., MCF-7 breast cancer cells transfected with protein kinase C-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J. clin. Invest., 95, 1906-1915 (1995).
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 1906-1915
-
-
Ways, D.K.1
Kukoly, C.A.2
Devente, Y.3
Hooker, Y.L.4
Brant, W.O.5
Posekany, J.K.6
Fletcher, D.J.7
Cook, P.P.8
Parker, P.J.9
-
36
-
-
0027248964
-
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
-
WILKINSON, S.E., PARKER, P.J. and NIXON, J.S., Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem. J., 294, 335-337 (1993).
-
(1993)
Biochem. J.
, vol.294
, pp. 335-337
-
-
Wilkinson, S.E.1
Parker, P.J.2
Nixon, J.S.3
-
37
-
-
0025913555
-
Transfection with protein kinase C a confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein
-
YU, G., AHMAD, S., AQUINO, A., FAIRCHILD, C.R., TREPEL, J.B., OHMO, S., SUZUKI, K., TSURUO, T., COWAN, K.H. and GLAZER, R.I., Transfection with protein kinase C a confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein. Cancer Comm., 3, 181-189 (1991).
-
(1991)
Cancer Comm.
, vol.3
, pp. 181-189
-
-
Yu, G.1
Ahmad, S.2
Aquino, A.3
Fairchild, C.R.4
Trepel, J.B.5
Ohmo, S.6
Suzuki, K.7
Tsuruo, T.8
Cowan, K.H.9
Glazer, R.I.10
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