UCN-01 in ovary cancer cells: Effective as a single agent and in combination with cis-diamminedichloroplatinum(II) independent of p53 status

Clinical Cancer Research

Volumn 3, Issue 11, 1997, Pages 2089-2097

  Husain, Amreen ^a   Yan, Xiu Jun ^a   Rosales, Nestor ^a   Aghajanian, Carol ^a   Schwartz, Gary K ^a   Spriggs, David R ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; CISPLATIN; COMPLEMENTARY DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CELL CYCLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL;

ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL SURVIVAL; CISPLATIN; DRUG SYNERGISM; FEMALE; GENES, P53; HUMANS; MUTAGENESIS; OVARIAN NEOPLASMS; RECOMBINANT PROTEINS; STAUROSPORINE; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030706078     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Akinaga, S., Gomi, K., and Morimoto, M. Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models. Cancer Res., 51: 4888-4892, 1991.
2. Wang, Q., Worland, P. J., Clark, J. L., Carlson, B. A., and Sausville, E. A. Apoptosis in 7-hydroxystaurosporine treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2. Cell Growth & Differ., 6: 927-936, 1995.
3. Seynaeve, C. M., Stetler-Stevenson, M., Sehers, S., Kaur, G., Sausville, E. A., and Worland, P. J. Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells. Cancer Res., 53: 2081-2086, 1993.
4. 2-checkpoint inhibitor. Clin. Cancer Res., 2: 791-797, 1996.
5. Akinaga, S., Nomura, K., Gomi, K., and Okabe, M. Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C. Cancer Chemother. Pharmacol., 32: 183-189, 1993.
6. Wang, Q., Fan, S., Eastman, A., Worland, P. J., Sausville, E. A., and O'Connor, P. M. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J. Natl. Cancer Inst, 88: 956-965, 1996.
7. Akinaga, S., Nomura, K., Gomi, K., and Okabe, M. Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell cycle distribution of human epidermoid carcinoma A431 cells. Cancer Chemother. Pharmacol., 33: 273-280, 1994.
8. Liu, Z., Hsu, H., Goeddel, D. V., and Karin, M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell, 87: 565-576, 1996.
9. Craig, R. The BCL-2 gene family. Semin. Cancer Biol., 6: 35-43, 1995.
10. Eliopoulos, A. G., Kerr, D. J., Herod, J., Hodgkins, L., Krajewski, S., Reed, J. C., and Young, L. S. The control of apoptosis and drug resistance in ovarian cancer: influence of p53 and Bcl-2. Oncogene, 11: 1217-1228, 1995.
11. Havrilesky, L. J. Regulation of apoptosis in normal and malignant ovarian epithelial cells by TGF β. Cancer Res., 55; 944-948, 1995.
12. Yaginima, Y. Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Res., 52: 4169-4199, 1992.
13. Holmen, S. L., Vanbrocklin, M. W., Eversole, R. R., Stapleton, S. R., and Ginsberg, L. C. Efficient lipid-mediated transfection of DNA into primary rat hepatocytes. In Vitro Cell. Dev. Biol. Anim., 31; 347-351, 1995.
14. Banerjee D, Lenz, H., Schnieders, B., Hochhauser, D., Danenberg, K., Danenberg, P., and Bertino, J. Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress. Cell Growth & Differ., 6: 1405-1413, 1995.
15. 3H] thymidine incorporation assay. J. Immunol. Methods, 170: 211-224, 1994.
16. Giaretti, W., and Nusse, M. Light scatter of isolated cell nuclei as a parameter discriminating the cell-cycle subcompartments. Methods Cell Biol., 41: 389-400, 1994.
17. Dignam, J. D., Lebovitz, R. M., and Roeder, R. G. Nucleic Acids Res., 11: 1475-1489, 1996.
18. Andrews, N. C., and Faller. D. V. Nucleic Acids Res., 19: 2499, 1991.
19. 1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. Cancer Res.. 57: 1495-1501, 1997.
20. Grant, S., and Jarvis, W. D. Modulation of drug-induced apoptosis by interruption of the protein kinase C signal transduction pathway: a new therapeutic strategy. Clin. Cancer Res., 2: 1915-1920, 1996.
21. Liu, Z. Baskaran, R., Lea-Chou, E. T., Wood, L. D., Chen, Y., Karin, M., and Wang, J. Y. J. Three distinct signaling responses by murine fibroblasts to genotoxic stress. Nature (Lond.), 384: 273-276, 1996.