메뉴 건너뛰기




Volumn 72, Issue 4, 1997, Pages 673-679

CEP-751 inhibits trk receptor tyrosine kinase activity in vitro and exhibits anti-tumor activity

Author keywords

[No Author keywords available]

Indexed keywords

CEP 751; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0030874174     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970807)72:4<673::AID-IJC20>3.0.CO;2-B     Document Type: Article
Times cited : (74)

References (43)
  • 1
    • 0026316096 scopus 로고
    • Growth factors and cancer
    • AARONSON, S.A., Growth factors and cancer. Science, 254, 1146-1153 (1991).
    • (1991) Science , vol.254 , pp. 1146-1153
    • Aaronson, S.A.1
  • 2
    • 0026558639 scopus 로고
    • Antitumor effect of KT6124, a novel derivative of protein kinase inhibitor K-252a, and its mechanism of action
    • AKINAGA, S., ASHIZAWA, T., GOMI, K., OHNO, H., MURIMOTO, M., MURAKATA, C. and OKABE, M., Antitumor effect of KT6124, a novel derivative of protein kinase inhibitor K-252a, and its mechanism of action. Cancer Chemother. Pharmacol., 2, 266-272 (1992).
    • (1992) Cancer Chemother. Pharmacol. , vol.2 , pp. 266-272
    • Akinaga, S.1    Ashizawa, T.2    Gomi, K.3    Ohno, H.4    Murimoto, M.5    Murakata, C.6    Okabe, M.7
  • 3
    • 0026425587 scopus 로고
    • Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models
    • AKINAGA, S., GOMI, K., MORIMOTO, M., TAMAOKI, T. and OKABE, M., Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models. Cancer Res., 51, 4888-1892 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 4888-11892
    • Akinaga, S.1    Gomi, K.2    Morimoto, M.3    Tamaoki, T.4    Okabe, M.5
  • 5
    • 0026512998 scopus 로고
    • K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity
    • BERG, M.M., STERNBERG, D.W., PARADA, L.F. and CHAO, M.V., K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity. J. biol. Chem., 267, 13-16 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 13-16
    • Berg, M.M.1    Sternberg, D.W.2    Parada, L.F.3    Chao, M.V.4
  • 7
    • 0029879618 scopus 로고    scopus 로고
    • Ret and trk proto-oncogene activation in thyroid papillary carcinomas in French patients from the Champagne-Ardenne region
    • DELVINCOURT, C., PATEY, M., FLAMENT, J.B., SUAREZ, H.G., LARBRE, H., JARDILLIER, J.C. and DELISLE, M.J., Ret and trk proto-oncogene activation in thyroid papillary carcinomas in French patients from the Champagne-Ardenne region. Clin. Biochem., 29, 267-271 (1996).
    • (1996) Clin. Biochem. , vol.29 , pp. 267-271
    • Delvincourt, C.1    Patey, M.2    Flament, J.B.3    Suarez, H.G.4    Larbre, H.5    Jardillier, J.C.6    Delisle, M.J.7
  • 8
    • 0025032508 scopus 로고
    • Cloning and expression of two distinct high affinity receptors cross-reacting with acidic and basic fibroblast growth factors
    • DIONNE, C.A., CRUMLEY, G., BELLOT, F., KAPLOW, J.M., SEARFOSS, G., RUTA, M., BURGESS, W.H., JAYE, M. and SCHLESSINGER, J., Cloning and expression of two distinct high affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J., 9, 2685-2692 (1990).
    • (1990) EMBO J. , vol.9 , pp. 2685-2692
    • Dionne, C.A.1    Crumley, G.2    Bellot, F.3    Kaplow, J.M.4    Searfoss, G.5    Ruta, M.6    Burgess, W.H.7    Jaye, M.8    Schlessinger, J.9
  • 10
    • 0028352507 scopus 로고
    • Protein tyrosine kinases as therapeutic targets in cancer chemotherapy and recent advances in the development of new inhibitors
    • FRY, D.W., Protein tyrosine kinases as therapeutic targets in cancer chemotherapy and recent advances in the development of new inhibitors. Exp. Opin. Invest. Drugs, 3, 577-595 (1994).
    • (1994) Exp. Opin. Invest. Drugs , vol.3 , pp. 577-595
    • Fry, D.W.1
  • 11
    • 0024166194 scopus 로고
    • Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potent inhibitor of insulin receptor than IGF-1 receptor
    • FUJITA-YAMAGUCHI, Y. and KATHURIA, S., Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potent inhibitor of insulin receptor than IGF-1 receptor. Biochem. biophys. Res. Comm., 157, 955-962 (1988).
    • (1988) Biochem. Biophys. Res. Comm. , vol.157 , pp. 955-962
    • Fujita-Yamaguchi, Y.1    Kathuria, S.2
  • 13
    • 0029043623 scopus 로고
    • Association of neurotrophin receptor expression and differentiation in human neuroblastoma
    • HOEHNER, J.C., OLSEN, L., SANDSTEDT, B., KAPLAN, D.R. and PAHLMAN, S., Association of neurotrophin receptor expression and differentiation in human neuroblastoma. Amer. J. Pathol., 147, 102-113 (1995).
    • (1995) Amer. J. Pathol. , vol.147 , pp. 102-113
    • Hoehner, J.C.1    Olsen, L.2    Sandstedt, B.3    Kaplan, D.R.4    Pahlman, S.5
  • 14
    • 0027323932 scopus 로고
    • Induction of trkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells
    • KAPLAN, D.R., MATSUMOTO, K., LUCARELLI, E. and THIELE, C.J., Induction of trkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. Neuron, 11, 321-331 (1993).
    • (1993) Neuron , vol.11 , pp. 321-331
    • Kaplan, D.R.1    Matsumoto, K.2    Lucarelli, E.3    Thiele, C.J.4
  • 15
    • 0028115022 scopus 로고
    • Neurotrophin signal transduction by the trk receptor
    • KAPLAN, D.R. and STEPHENS, R.M., Neurotrophin signal transduction by the trk receptor. J. Neurobiol., 25, 1404-1417 (1994).
    • (1994) J. Neurobiol. , vol.25 , pp. 1404-1417
    • Kaplan, D.R.1    Stephens, R.M.2
  • 16
    • 0022500301 scopus 로고
    • K-252a, a potent inhibitor of protein kinase C from microbial origin
    • KASE, H., IWAHASHI, K. and MATSUDA, Y., K-252a, a potent inhibitor of protein kinase C from microbial origin. J. Antibiotics, 39, 1059-1065 (1986).
    • (1986) J. Antibiotics , vol.39 , pp. 1059-1065
    • Kase, H.1    Iwahashi, K.2    Matsuda, Y.3
  • 17
    • 0027285262 scopus 로고
    • Coexpression of messenger RNA for trk protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis
    • KOGNER, P., BARBANY, G., DOMINICI, C., CASTELLO, M.A., RASCHELLA, G. and PERSSON, H., Coexpression of messenger RNA for trk protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis. Cancer Res., 53, 2044-2050 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 2044-2050
    • Kogner, P.1    Barbany, G.2    Dominici, C.3    Castello, M.A.4    Raschella, G.5    Persson, H.6
  • 18
    • 0028870428 scopus 로고
    • K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells
    • MARONEY, A.C., LIPFERT, L., FORBES, M.E., GLICKSMAN, M.A., NEFF, N.T., SIMAN, R. and DIONNE, C.A., K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells. J. Neurochem., 64, 540-549 (1995).
    • (1995) J. Neurochem. , vol.64 , pp. 540-549
    • Maroney, A.C.1    Lipfert, L.2    Forbes, M.E.3    Glicksman, M.A.4    Neff, N.T.5    Siman, R.6    Dionne, C.A.7
  • 20
    • 0022641294 scopus 로고
    • A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
    • MARTIN-ZANCA, D., HUGHES, S.H. and BARBACID, M., A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature (Lond.), 319, 743-748 (1986).
    • (1986) Nature (Lond.) , vol.319 , pp. 743-748
    • Martin-Zanca, D.1    Hughes, S.H.2    Barbacid, M.3
  • 21
  • 22
    • 0026561025 scopus 로고
    • The rat trk proto-oncogene product exhibits properties characteristic of the slow nerve growth factor receptor
    • MEAKIN, S.O., SUTER, U., DRINKWATER, C.C., WELCHER, A.A. and SHOOTER, E.M., The rat trk proto-oncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Proc. nat. Acad. Sci. (Wash.), 89, 2374-2378 (1992).
    • (1992) Proc. Nat. Acad. Sci. (Wash.) , vol.89 , pp. 2374-2378
    • Meakin, S.O.1    Suter, U.2    Drinkwater, C.C.3    Welcher, A.A.4    Shooter, E.M.5
  • 23
    • 0028140040 scopus 로고
    • Production and characterization of recombinant mouse brain-derived neurotrophic factor and rat neurotrophin-3 expressed in insect cells
    • MEYER, S.L., LANG, D.M., FORBES, M.E., KNIGHT, E., JR., HIRSCH, J.D., TRUSKO, S.P. and SCOTT, R.W., Production and characterization of recombinant mouse brain-derived neurotrophic factor and rat neurotrophin-3 expressed in insect cells. J. Neurochem., 62, 825-833 (1994).
    • (1994) J. Neurochem. , vol.62 , pp. 825-833
    • Meyer, S.L.1    Lang, D.M.2    Forbes, M.E.3    Knight Jr., E.4    Hirsch, J.D.5    Trusko, S.P.6    Scott, R.W.7
  • 25
    • 0026552457 scopus 로고
    • Inverse relationship between trk expression and N-myc amplification in human neuroblastomas
    • NAKAGAWARA, A., ARIMA, M., AZAR, C.G., SCAVARDA, N.J. and BRODEUR, G.M., Inverse relationship between trk expression and N-myc amplification in human neuroblastomas. Cancer Res., 52, 1364-1368 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 1364-1368
    • Nakagawara, A.1    Arima, M.2    Azar, C.G.3    Scavarda, N.J.4    Brodeur, G.M.5
  • 26
    • 0027531016 scopus 로고
    • Association between high levels of expression of the trk gene and favorable outcome in human neuroblastoma
    • NAKAGAWARA, A., ARIMA-NAKAGAWARA, M., SCAVARDA, N.J., AZAR, C.G., CANTOR, A.B. and BRODEUR, G.M., Association between high levels of expression of the trk gene and favorable outcome in human neuroblastoma. N. Engl. J. Med., 328, 847-854 (1993).
    • (1993) N. Engl. J. Med. , vol.328 , pp. 847-854
    • Nakagawara, A.1    Arima-Nakagawara, M.2    Scavarda, N.J.3    Azar, C.G.4    Cantor, A.B.5    Brodeur, G.M.6
  • 27
    • 0028107269 scopus 로고
    • Expression and function of trkB and BDNF in human neuroblastomas
    • NAKAGAWARA, A., AZAR, C.G., SCAVARDA, N.J. and BRODEUR, G.M., Expression and function of trkB and BDNF in human neuroblastomas. Mol. cell. Biol., 14, 759-767 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 759-767
    • Nakagawara, A.1    Azar, C.G.2    Scavarda, N.J.3    Brodeur, G.M.4
  • 28
    • 0022508995 scopus 로고
    • K-252b, c and d, potent inhibitors of protein kinase C from microbial origin
    • NAKANISHI, S., MATSUDA, Y, IWAHASHI, K. and KASE, H., K-252b, c and d, potent inhibitors of protein kinase C from microbial origin. J. Antibiotics, 39, 1066-1071 (1986).
    • (1986) J. Antibiotics , vol.39 , pp. 1066-1071
    • Nakanishi, S.1    Matsuda, Y.2    Iwahashi, K.3    Kase, H.4
  • 30
    • 0026684676 scopus 로고
    • Inhibition of the cellular actions of nerve growth factor by staurosporine and K252a results from the attenuation of the activity of the trk tyrosine kinase
    • OHMICHI, M., DECKER, S.J., PANG. L. and SALTIEL, A.R., Inhibition of the cellular actions of nerve growth factor by staurosporine and K252a results from the attenuation of the activity of the trk tyrosine kinase. Biochemistry, 31, 4034-4039 (1992).
    • (1992) Biochemistry , vol.31 , pp. 4034-4039
    • Ohmichi, M.1    Decker, S.J.2    Pang, L.3    Saltiel, A.R.4
  • 31
    • 0027209064 scopus 로고
    • The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor
    • OHMICHI, M., PANG, L., RIBON, V., GAZIT, A., LEVITZKI, A. and SALTIEL, A.R., The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Biochemistry, 32, 4650-4658 ( 1993).
    • (1993) Biochemistry , vol.32 , pp. 4650-4658
    • Ohmichi, M.1    Pang, L.2    Ribon, V.3    Gazit, A.4    Levitzki, A.5    Saltiel, A.R.6
  • 32
    • 0029114101 scopus 로고
    • Staurosporine, a potentially important gift from a microorsanism
    • OMURA, S., SASAKI, Y., IWAI, Y. and TAKESHIMA, H., Staurosporine, a potentially important gift from a microorsanism. J. Antibiotics, 48, 535-548 (1995).
    • (1995) J. Antibiotics , vol.48 , pp. 535-548
    • Omura, S.1    Sasaki, Y.2    Iwai, Y.3    Takeshima, H.4
  • 33
    • 0030254481 scopus 로고    scopus 로고
    • Neurotrophin receptors, tumor progression and tumor maturation
    • PAHLMAN, S. and HOEHNER, J.C., Neurotrophin receptors, tumor progression and tumor maturation. Mol. Med. Today, 2, 432-438 (1996).
    • (1996) Mol. Med. Today , vol.2 , pp. 432-438
    • Pahlman, S.1    Hoehner, J.C.2
  • 34
    • 0028851242 scopus 로고
    • Expression of a trk high affinity nerve growth factor receptor in the human prostate
    • PFLUG, B.R., DIONNE, C., KAPLAN, D.R., LYNCH, J. and DJAKIEW, D., Expression of a trk high affinity nerve growth factor receptor in the human prostate. Endocrinology, 136, 262-268 (1995).
    • (1995) Endocrinology , vol.136 , pp. 262-268
    • Pflug, B.R.1    Dionne, C.2    Kaplan, D.R.3    Lynch, J.4    Djakiew, D.5
  • 36
    • 0027213559 scopus 로고
    • The receptors for nerve growth factor and other neurotrophins
    • RAFFIONI, S. and BRADSHAW, R.A., The receptors for nerve growth factor and other neurotrophins. Ann. Rev. Biochem., 62, 823-850 (1993).
    • (1993) Ann. Rev. Biochem. , vol.62 , pp. 823-850
    • Raffioni, S.1    Bradshaw, R.A.2
  • 38
    • 0028568009 scopus 로고
    • Expression of the neurotrophin receptor trkC is linked to a favorable outcome in medulloblastoma
    • SEGAL, R.A., GOUMNEROVA, L.C., KWON, Y.K., STILES, C.D. and POMEROY, S.L., Expression of the neurotrophin receptor trkC is linked to a favorable outcome in medulloblastoma. P roc. nat. Acad. Sci. (Wash.), 91, 12867-12871 (1994).
    • (1994) P Roc. Nat. Acad. Sci. (Wash.) , vol.91 , pp. 12867-12871
    • Segal, R.A.1    Goumnerova, L.C.2    Kwon, Y.K.3    Stiles, C.D.4    Pomeroy, S.L.5
  • 39
    • 0027456537 scopus 로고
    • Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas
    • SUZUKI, T., BOGENMANN, E., SHIMADA, H., STRAM, D. and SEEGER, R.C., Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas. J. nat. Cancer Inst., 85, 377-384 (1993).
    • (1993) J. Nat. Cancer Inst. , vol.85 , pp. 377-384
    • Suzuki, T.1    Bogenmann, E.2    Shimada, H.3    Stram, D.4    Seeger, R.C.5
  • 40
    • 0026563244 scopus 로고
    • K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors
    • TAPLEY, P., LAMBALLE, F. and BARBACID, M., K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. Oncogene, 7, 371-381 (1992).
    • (1992) Oncogene , vol.7 , pp. 371-381
    • Tapley, P.1    Lamballe, F.2    Barbacid, M.3
  • 41
    • 0027161499 scopus 로고
    • The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC-12 cells
    • TSOULFAS, P., SOPPET, D., ESCANDON, E., TESSAROLLO, L., MENDOZA-RAMIREZ, J.-L., ROSENTHAL, A., NIKOLICS, K. and PARADA, L.F., The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC-12 cells. Neuron, 10, 975-990 (1993).
    • (1993) Neuron , vol.10 , pp. 975-990
    • Tsoulfas, P.1    Soppet, D.2    Escandon, E.3    Tessarollo, L.4    Mendoza-Ramirez, J.-L.5    Rosenthal, A.6    Nikolics, K.7    Parada, L.F.8
  • 42
    • 0030091609 scopus 로고    scopus 로고
    • Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system
    • WASHIYAMA, K., MURAGAKI, Y, RORKE, L.B., LEE, V.M.-Y., FEINSTEIN, S.C., RADEKE, M.J., BLUMBERG, D., KAPLAN, D.R. and TROJANOWSKI, J.Q., Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system. Amer. J. Pathol., 148, 929-940 (1996).
    • (1996) Amer. J. Pathol. , vol.148 , pp. 929-940
    • Washiyama, K.1    Muragaki, Y.2    Rorke, L.B.3    Lee, V.M.-Y.4    Feinstein, S.C.5    Radeke, M.J.6    Blumberg, D.7    Kaplan, D.R.8    Trojanowski, J.Q.9
  • 43
    • 0026486446 scopus 로고
    • Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erbB2 receptor
    • WELS, W., HARWERTH, I.-M., MUELLER, M., GRONER, B. and HYNES, N.E., Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erbB2 receptor. Cancer Res., 52, 6310-6317 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 6310-6317
    • Wels, W.1    Harwerth, I.-M.2    Mueller, M.3    Groner, B.4    Hynes, N.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.