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Volumn 47, Issue 3, 2000, Pages 252-266

Pharmacogenetics of antipsychotic treatment: Lessons learned from clozapine

Author keywords

Antipsychotic response; Clozapine; Pharmacodynamic; Pharmacogenetic; Pharmacokinetic; Polymorphism

Indexed keywords

CLOZAPINE;

EID: 0033959580     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00298-X     Document Type: Review
Times cited : (83)

References (114)
  • 1
    • 0031028361 scopus 로고    scopus 로고
    • Transmission-disequilibrium tests for quantitative traits
    • Allison D.B. Transmission-disequilibrium tests for quantitative traits. Am J Hum Genet. 60:1997;676-690.
    • (1997) Am J Hum Genet , vol.60 , pp. 676-690
    • Allison, D.B.1
  • 2
    • 0022922681 scopus 로고
    • Typical and atypical antipsychotic occupancy of D2 and S2 receptors: An autoradiographic analysis in rat brain
    • Altar C.A., Wasley A.M., Neale R.F., Stone G.A. Typical and atypical antipsychotic occupancy of D2 and S2 receptors An autoradiographic analysis in rat brain . Brain Res Bull. 16:1986;517-525.
    • (1986) Brain Res Bull , vol.16 , pp. 517-525
    • Altar, C.A.1    Wasley, A.M.2    Neale, R.F.3    Stone, G.A.4
  • 3
    • 0030698705 scopus 로고    scopus 로고
    • Blood clozapine levels elevated by fluvoxamine: Potential for side effects and lower clozapine dosage
    • Armstrong S.C., Stephans J.R. Blood clozapine levels elevated by fluvoxamine Potential for side effects and lower clozapine dosage . J Clin Psychiatry. 58:1997;499.
    • (1997) J Clin Psychiatry , vol.58 , pp. 499
    • Armstrong, S.C.1    Stephans, J.R.2
  • 4
    • 0029100429 scopus 로고
    • Association between clozapine response and allelic variation in 5-HT2A receptor gene
    • Arranz M., Collier D., Sodhi M., et al. Association between clozapine response and allelic variation in 5-HT2A receptor gene. Lancet. 346:1995;281-282.
    • (1995) Lancet , vol.346 , pp. 281-282
    • Arranz, M.1    Collier, D.2    Sodhi, M.3
  • 5
    • 0030592571 scopus 로고    scopus 로고
    • Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine
    • Arranz M.J., Collier D.A., Munro J., et al. Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine. Neurosci Lett. 217:1996;177-178.
    • (1996) Neurosci Lett , vol.217 , pp. 177-178
    • Arranz, M.J.1    Collier, D.A.2    Munro, J.3
  • 6
    • 0028902662 scopus 로고
    • Cytochrome P4502D6 genotype does not determine response to clozapine
    • Arranz M.J., Dawson E., Shaikh S., et al. Cytochrome P4502D6 genotype does not determine response to clozapine. Br J Clin Pharmacol. 39:1995;417-420.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 417-420
    • Arranz, M.J.1    Dawson, E.2    Shaikh, S.3
  • 7
    • 0032217288 scopus 로고    scopus 로고
    • Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine response
    • Arranz M.J., Li T., Munro J., et al. Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine response. Pharmacogenetics. 8:1998;481-484.
    • (1998) Pharmacogenetics , vol.8 , pp. 481-484
    • Arranz, M.J.1    Li, T.2    Munro, J.3
  • 8
    • 0031963472 scopus 로고    scopus 로고
    • Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine
    • Arranz M.J., Munro J., Owen M.J., et al. Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine. Mol Psychiatry. 3:1998;61-66.
    • (1998) Mol Psychiatry , vol.3 , pp. 61-66
    • Arranz, M.J.1    Munro, J.2    Owen, M.J.3
  • 9
    • 0032572611 scopus 로고    scopus 로고
    • Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response
    • Arranz M.J., Munro J., Sham P., et al. Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response. Schizophr Res. 32:1998;93-99.
    • (1998) Schizophr Res , vol.32 , pp. 93-99
    • Arranz, M.J.1    Munro, J.2    Sham, P.3
  • 10
    • 10544244163 scopus 로고    scopus 로고
    • Pharmacological actions of the atypical antipsychotic drug clozapine: A review
    • Ashby C.R., Wang R.Y. Pharmacological actions of the atypical antipsychotic drug clozapine A review . Synapse. 24:1996;349-394.
    • (1996) Synapse , vol.24 , pp. 349-394
    • Ashby, C.R.1    Wang, R.Y.2
  • 11
    • 0032982269 scopus 로고    scopus 로고
    • Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia
    • Basile V.S., Masellis M., Badri F., et al. Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia. Neuropsychopharmacology. 21:1999;17-27.
    • (1999) Neuropsychopharmacology , vol.21 , pp. 17-27
    • Basile, V.S.1    Masellis, M.2    Badri, F.3
  • 12
    • 0031872240 scopus 로고    scopus 로고
    • The clinical use of plasma clozapine levels
    • Bell R., McLaren A., Galanos J., et al. The clinical use of plasma clozapine levels. Aust N Z J Psychiatry. 32:1998;567-574.
    • (1998) Aust N Z J Psychiatry , vol.32 , pp. 567-574
    • Bell, R.1    McLaren, A.2    Galanos, J.3
  • 13
    • 0031734270 scopus 로고    scopus 로고
    • Very high cytochrome P4501A2 activity and nonresponse to clozapine
    • Bender S., Eap C.B. Very high cytochrome P4501A2 activity and nonresponse to clozapine. Arch Gen Psychiatry. 55:1998;1048-1050.
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 1048-1050
    • Bender, S.1    Eap, C.B.2
  • 14
    • 0027985726 scopus 로고
    • Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test
    • Bertilsson L., Carrillo J.A., Dahl M.L., et al. Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test. Br J Clin Pharmacol. 38:1994;471-473.
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 471-473
    • Bertilsson, L.1    Carrillo, J.A.2    Dahl, M.L.3
  • 15
    • 0009404019 scopus 로고    scopus 로고
    • Pharmacokinetics of clozapine and risperidone: A review of recent literature
    • Byerly M., DeVane L. Pharmacokinetics of clozapine and risperidone A review of recent literature . J Clin Psychopharmacol. 16:1996;177-187.
    • (1996) J Clin Psychopharmacol , vol.16 , pp. 177-187
    • Byerly, M.1    Devane, L.2
  • 16
    • 0031903147 scopus 로고    scopus 로고
    • Effects of caffeine withdrawal from the diet on the metabolism of clozapine in schizophrenic patients
    • Carrillo J.A., Herraiz A.G., Ramos S.I., et al. Effects of caffeine withdrawal from the diet on the metabolism of clozapine in schizophrenic patients. J Clin Psychopharmacol. 18:1998;311-316.
    • (1998) J Clin Psychopharmacol , vol.18 , pp. 311-316
    • Carrillo, J.A.1    Herraiz, A.G.2    Ramos, S.I.3
  • 17
    • 0023908085 scopus 로고
    • Clinical pharmacokinetics of clozapine in chronic schizophrenic patients
    • Cheng Y.F., Lundberg T., Bondesson U., et al. Clinical pharmacokinetics of clozapine in chronic schizophrenic patients. Eur J Clin Pharmacol. 34:1988;445-449.
    • (1988) Eur J Clin Pharmacol , vol.34 , pp. 445-449
    • Cheng, Y.F.1    Lundberg, T.2    Bondesson, U.3
  • 18
    • 0025032064 scopus 로고
    • Single- vs multiple-dose pharmacokinetics of clozapine in psychiatric patients
    • Choc M.G., Hsuan F., Honigfeld G., et al. Single- vs multiple-dose pharmacokinetics of clozapine in psychiatric patients. Pharm Res. 7:1990;347-351.
    • (1990) Pharm Res , vol.7 , pp. 347-351
    • Choc, M.G.1    Hsuan, F.2    Honigfeld, G.3
  • 19
    • 0023475155 scopus 로고
    • Multiple-dose pharmacokinetics of clozapine in patients
    • Choc M.G., Lehr R.G., Hsuan F., et al. Multiple-dose pharmacokinetics of clozapine in patients. Pharm Res. 4:1987;402-405.
    • (1987) Pharm Res , vol.4 , pp. 402-405
    • Choc, M.G.1    Lehr, R.G.2    Hsuan, F.3
  • 20
    • 0032587535 scopus 로고    scopus 로고
    • Polymorphisms of the dopamine D4 receptor and response to antipsychotic drugs
    • Cohen B.M., Ennulat D.J., Centorrino F., et al. Polymorphisms of the dopamine D4 receptor and response to antipsychotic drugs. Psychopharmacology (Berl). 141:1999;6-10.
    • (1999) Psychopharmacology (Berl) , vol.141 , pp. 6-10
    • Cohen, B.M.1    Ennulat, D.J.2    Centorrino, F.3
  • 21
    • 0029089575 scopus 로고
    • Heterogeneity in meta-analysis of data from epidemiologic studies: A commentary
    • Colditz G.A., Burdick E., Mosteller F. Heterogeneity in meta-analysis of data from epidemiologic studies A commentary . Am J Epidemiol. 142:1995;371-382.
    • (1995) Am J Epidemiol , vol.142 , pp. 371-382
    • Colditz, G.A.1    Burdick, E.2    Mosteller, F.3
  • 22
    • 0027236042 scopus 로고
    • Candidate genes in psychiatry: An epidemiological perspective
    • Crowe R.R. Candidate genes in psychiatry an epidemiological perspective . Am J Med Genet. 48:1993;74-77.
    • (1993) Am J Med Genet , vol.48 , pp. 74-77
    • Crowe, R.R.1
  • 23
    • 0030440923 scopus 로고    scopus 로고
    • Genetics, neuroleptic response and the organization of cholinergic neurons in the mouse striatum
    • Dains K., Hitzemann B., Hitzemann R. Genetics, neuroleptic response and the organization of cholinergic neurons in the mouse striatum. J Pharmacol Exp Ther. 279:1996;1430-1438.
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 1430-1438
    • Dains, K.1    Hitzemann, B.2    Hitzemann, R.3
  • 24
    • 84984934048 scopus 로고    scopus 로고
    • DNA microarrays in drug discovery and development
    • Debouck C., Goodfellow P.N. DNA microarrays in drug discovery and development. Nat Genet. 21:1999;48-50.
    • (1999) Nat Genet , vol.21 , pp. 48-50
    • Debouck, C.1    Goodfellow, P.N.2
  • 26
    • 0031795349 scopus 로고    scopus 로고
    • Linkage and association
    • Elston R.C. Linkage and association. Genet Epidemiol. 15:1998;565-576.
    • (1998) Genet Epidemiol , vol.15 , pp. 565-576
    • Elston, R.C.1
  • 27
    • 0026718710 scopus 로고
    • Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects
    • Farde L., Nordstrom A.L., Wiesel F.A., et al. Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry. 49:1992;538-544.
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 538-544
    • Farde, L.1    Nordstrom, A.L.2    Wiesel, F.A.3
  • 31
    • 0027740188 scopus 로고
    • Relationship between clinical efficacy and clozapine concentrations in plasma in schizophrenia: Effect of smoking
    • Hasegawa M., Gutierrez-Esteinou R., Way L., et al. Relationship between clinical efficacy and clozapine concentrations in plasma in schizophrenia Effect of smoking . J Clin Psychopharmacol. 13:1993;383-390.
    • (1993) J Clin Psychopharmacol , vol.13 , pp. 383-390
    • Hasegawa, M.1    Gutierrez-Esteinou, R.2    Way, L.3
  • 32
    • 0028016505 scopus 로고
    • Elevated levels of clozapine in serum after addition of fluvoxamine
    • Hiemke C., Weigmann H., Hartter S., et al. Elevated levels of clozapine in serum after addition of fluvoxamine. J Clin Psychopharmacol. 14:1994;279-281.
    • (1994) J Clin Psychopharmacol , vol.14 , pp. 279-281
    • Hiemke, C.1    Weigmann, H.2    Hartter, S.3
  • 33
    • 0028673166 scopus 로고
    • What association analysis can and cannot tell us about the genetics of complex disease
    • Hodge S.E. What association analysis can and cannot tell us about the genetics of complex disease. Am J Med Genet. 54:1994;318-323.
    • (1994) Am J Med Genet , vol.54 , pp. 318-323
    • Hodge, S.E.1
  • 34
    • 0032091881 scopus 로고    scopus 로고
    • Why pharmacogenomics? Why now?
    • Housman D., Ledley F.D. Why pharmacogenomics? Why now? Nat Biotechnol. 16:1998;492-493.
    • (1998) Nat Biotechnol , vol.16 , pp. 492-493
    • Housman, D.1    Ledley, F.D.2
  • 35
    • 17544400122 scopus 로고    scopus 로고
    • Dopamine D4 receptor gene polymorphisms and neuroleptic response in schizophrenia
    • Hwu H.G., Hong C.J., Lee Y.L., et al. Dopamine D4 receptor gene polymorphisms and neuroleptic response in schizophrenia. Biol Psychiatry. 44:1998;483-487.
    • (1998) Biol Psychiatry , vol.44 , pp. 483-487
    • Hwu, H.G.1    Hong, C.J.2    Lee, Y.L.3
  • 36
    • 0028318482 scopus 로고
    • Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: Evidence from a therapeutic drug monitoring service
    • Jerling M., Lindstrom L., Bondesson U., et al. Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine Evidence from a therapeutic drug monitoring service . Ther Drug Monit. 16:1994;368-374.
    • (1994) Ther Drug Monit , vol.16 , pp. 368-374
    • Jerling, M.1    Lindstrom, L.2    Bondesson, U.3
  • 37
    • 0033090841 scopus 로고    scopus 로고
    • T102C polymorphism in the 5HT2A gene and schizophrenia: Relation to phenotype and drug response variability
    • Joober R., Benkelfat C., Brisebois K., et al. T102C polymorphism in the 5HT2A gene and schizophrenia Relation to phenotype and drug response variability . J Psychiatry Neurosci. 24:1999;141-146.
    • (1999) J Psychiatry Neurosci , vol.24 , pp. 141-146
    • Joober, R.1    Benkelfat, C.2    Brisebois, K.3
  • 38
    • 0031826288 scopus 로고    scopus 로고
    • Hypothesis: Comparisons of inter- And intra-individual variations can substitute for twin studies in drug research
    • Kalow W., Tang B.K., Endrenyi L. Hypothesis Comparisons of inter- and intra-individual variations can substitute for twin studies in drug research . Pharmacogenetics. 8:1998;283-289.
    • (1998) Pharmacogenetics , vol.8 , pp. 283-289
    • Kalow, W.1    Tang, B.K.2    Endrenyi, L.3
  • 39
    • 0030568166 scopus 로고    scopus 로고
    • Schizophrenia
    • Kane J.M. Schizophrenia. N Engl J Med. 334:1996;34-41.
    • (1996) N Engl J Med , vol.334 , pp. 34-41
    • Kane, J.M.1
  • 40
    • 0031943647 scopus 로고    scopus 로고
    • A new framework for investigating antipsychotic action in humans: Lessons from PET imaging
    • Kapur S. A new framework for investigating antipsychotic action in humans Lessons from PET imaging . Mol Psychiatry. 3:1998;135-140.
    • (1998) Mol Psychiatry , vol.3 , pp. 135-140
    • Kapur, S.1
  • 41
    • 0029988896 scopus 로고    scopus 로고
    • Serotonin-dopamine interaction and its relevance to schizophrenia
    • Kapur S., Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry. 153:1996;466-476.
    • (1996) Am J Psychiatry , vol.153 , pp. 466-476
    • Kapur, S.1    Remington, G.2
  • 42
    • 0032982714 scopus 로고    scopus 로고
    • Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia
    • Kapur S., Zipursky R.B., Remington G. Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia. Am J Psychiatry. 156:1999;286-293.
    • (1999) Am J Psychiatry , vol.156 , pp. 286-293
    • Kapur, S.1    Zipursky, R.B.2    Remington, G.3
  • 43
    • 0029927536 scopus 로고    scopus 로고
    • Mechanisms of action of atypical antipsychotic drugs: A critical analysis
    • Kinon B.J., Lieberman J.A. Mechanisms of action of atypical antipsychotic drugs A critical analysis . Psychopharmacology (Berl). 124:1996;2-34.
    • (1996) Psychopharmacology (Berl) , vol.124 , pp. 2-34
    • Kinon, B.J.1    Lieberman, J.A.2
  • 44
    • 0030940989 scopus 로고    scopus 로고
    • Dopamine D4 receptor gene polymorphisms: Relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects
    • Kohn Y., Ebstein R.P., HerescoLevy U., et al. Dopamine D4 receptor gene polymorphisms relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects . Eur Neuropsychopharmacol. 7:1997;39-43.
    • (1997) Eur Neuropsychopharmacol , vol.7 , pp. 39-43
    • Kohn, Y.1    Ebstein, R.P.2    Herescolevy, U.3
  • 45
    • 0028877764 scopus 로고
    • Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients
    • Kronig M.H., Munne R.A., Szymanski S., et al. Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients. Am J Psychiatry. 152:1995;179-182.
    • (1995) Am J Psychiatry , vol.152 , pp. 179-182
    • Kronig, M.H.1    Munne, R.A.2    Szymanski, S.3
  • 46
    • 0029032864 scopus 로고
    • Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C)
    • Lappalainen J., Zhang L., Dean M., et al. Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). Genomics. 27:1995;274-279.
    • (1995) Genomics , vol.27 , pp. 274-279
    • Lappalainen, J.1    Zhang, L.2    Dean, M.3
  • 48
    • 0032818128 scopus 로고    scopus 로고
    • Can pharmacogenomics make a difference in drug development?
    • Ledley F.D. Can pharmacogenomics make a difference in drug development? Nat Biotechnol. 17:1999;731.
    • (1999) Nat Biotechnol , vol.17 , pp. 731
    • Ledley, F.D.1
  • 49
    • 0029977951 scopus 로고    scopus 로고
    • Atypical antipsychotic drugs as a first-line treatment of schizophrenia: A rationale and hypothesis
    • Lieberman J.A. Atypical antipsychotic drugs as a first-line treatment of schizophrenia A rationale and hypothesis . J Clin Psychiatry. 57:1996;68-71.
    • (1996) J Clin Psychiatry , vol.57 , pp. 68-71
    • Lieberman, J.A.1
  • 50
    • 0031958032 scopus 로고    scopus 로고
    • Maximizing clozapine therapy: Managing side effects
    • Lieberman J.A. Maximizing clozapine therapy managing side effects . J Clin Psychiatry. 59:1998;38-43.
    • (1998) J Clin Psychiatry , vol.59 , pp. 38-43
    • Lieberman, J.A.1
  • 51
    • 0028007550 scopus 로고
    • Clinical effects of clozapine in chronic schizophrenia: Response to treatment and predictors of outcome
    • Lieberman J.A., Safferman A.Z., Pollack S., et al. Clinical effects of clozapine in chronic schizophrenia Response to treatment and predictors of outcome . Am J Psychiatry. 151:1994;1744-1752.
    • (1994) Am J Psychiatry , vol.151 , pp. 1744-1752
    • Lieberman, J.A.1    Safferman, A.Z.2    Pollack, S.3
  • 52
    • 0002964661 scopus 로고    scopus 로고
    • No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia or clozapine response in a Chinese population
    • Lin C.H., Tsai S.J., Yu Y.W., et al. No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia or clozapine response in a Chinese population. Neuroreport. 10:1999;57-60.
    • (1999) Neuroreport , vol.10 , pp. 57-60
    • Lin, C.H.1    Tsai, S.J.2    Yu, Y.W.3
  • 53
    • 0033106068 scopus 로고    scopus 로고
    • Benefits and pitfalls encountered in psychiatric genetic association studies
    • Malhotra A.K., Goldman D. Benefits and pitfalls encountered in psychiatric genetic association studies. Biol Psychiatry. 45:1999;544-550.
    • (1999) Biol Psychiatry , vol.45 , pp. 544-550
    • Malhotra, A.K.1    Goldman, D.2
  • 54
    • 0031594223 scopus 로고    scopus 로고
    • The dopamine D3 receptor (DRD3) Ser9Gly polymorphism and schizophrenia: A haplotype relative risk study and association with clozapine response
    • Malhotra A.K., Goldman D., Buchanan R.W., et al. The dopamine D3 receptor (DRD3) Ser9Gly polymorphism and schizophrenia A haplotype relative risk study and association with clozapine response . Mol Psychiatry. 3:1998;72-75.
    • (1998) Mol Psychiatry , vol.3 , pp. 72-75
    • Malhotra, A.K.1    Goldman, D.2    Buchanan, R.W.3
  • 55
    • 0029658220 scopus 로고    scopus 로고
    • Clozapine response and the 5HT(2C)Cys(23)Ser polymorphism
    • Malhotra A.K., Goldman D., Ozaki N., et al. Clozapine response and the 5HT(2C)Cys(23)Ser polymorphism. Neuroreport. 7:1996;2100-2102.
    • (1996) Neuroreport , vol.7 , pp. 2100-2102
    • Malhotra, A.K.1    Goldman, D.2    Ozaki, N.3
  • 56
    • 0029790119 scopus 로고    scopus 로고
    • Lack of associaton between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine
    • Malhotra A.K., Goldman D., Ozaki N., et al. Lack of associaton between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine. Am J Psychiatry. 153:1996;1092-1094.
    • (1996) Am J Psychiatry , vol.153 , pp. 1092-1094
    • Malhotra, A.K.1    Goldman, D.2    Ozaki, N.3
  • 57
    • 0031861847 scopus 로고    scopus 로고
    • Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients
    • Masellis M., Basile V., Meltzer H.Y., et al. Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients. Neuropsychopharmacology. 19:1998;123-132.
    • (1998) Neuropsychopharmacology , vol.19 , pp. 123-132
    • Masellis, M.1    Basile, V.2    Meltzer, H.Y.3
  • 58
    • 0035863032 scopus 로고    scopus 로고
    • 6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia
    • (in press)
    • 6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. Schizophr Res.
    • Schizophr Res.
    • Masellis, M.1    Basile, V.S.2    Meltzer, H.Y.3
  • 59
    • 0028862241 scopus 로고
    • Genetic variation of 5-HT2A receptor and response to clozapine
    • Masellis M., Paterson A.D., Badri F., et al. Genetic variation of 5-HT2A receptor and response to clozapine. Lancet. 346:1995;1108.
    • (1995) Lancet , vol.346 , pp. 1108
    • Masellis, M.1    Paterson, A.D.2    Badri, F.3
  • 60
    • 0029131849 scopus 로고
    • Genetic basis of schizophrenia
    • McGuffin P., Owen M.J., Farmer A.E. Genetic basis of schizophrenia. Lancet. 346:1995;678-682.
    • (1995) Lancet , vol.346 , pp. 678-682
    • McGuffin, P.1    Owen, M.J.2    Farmer, A.E.3
  • 61
    • 0024468417 scopus 로고
    • Clinical studies on the mechanism of action of clozapine: The dopamine-serotonin hypothesis of schizophrenia
    • Meltzer H.Y. Clinical studies on the mechanism of action of clozapine The dopamine-serotonin hypothesis of schizophrenia . Psychopharmacology. 99:1989;S18-S27.
    • (1989) Psychopharmacology , vol.99
    • Meltzer, H.Y.1
  • 62
    • 0024706878 scopus 로고
    • Duration of a clozapine trial in neuroleptic-resistant schizophrenia
    • Meltzer H.Y. Duration of a clozapine trial in neuroleptic-resistant schizophrenia. Arch Gen Psychiatry. 46:1989;672.
    • (1989) Arch Gen Psychiatry , vol.46 , pp. 672
    • Meltzer, H.Y.1
  • 63
    • 0028114486 scopus 로고
    • An overview of the mechanism of action of clozapine
    • Meltzer H.Y. An overview of the mechanism of action of clozapine. J Clin Psychiatry. 55:1994;47-52.
    • (1994) J Clin Psychiatry , vol.55 , pp. 47-52
    • Meltzer, H.Y.1
  • 65
    • 0029070691 scopus 로고
    • Clozapine: Is another view valid?
    • Meltzer H.Y. Clozapine Is another view valid? Am J Psychiatry. 152:1995;821-825.
    • (1995) Am J Psychiatry , vol.152 , pp. 821-825
    • Meltzer, H.Y.1
  • 66
    • 0029197942 scopus 로고
    • Role of serotonin in the action of atypical antipsychotic drugs
    • Meltzer H.Y. Role of serotonin in the action of atypical antipsychotic drugs. Clin Neurosci. 3:1995;64-75.
    • (1995) Clin Neurosci , vol.3 , pp. 64-75
    • Meltzer, H.Y.1
  • 67
    • 0032868798 scopus 로고    scopus 로고
    • The role of serotonin in antipsychotic drug action
    • Meltzer H.Y. The role of serotonin in antipsychotic drug action. Neuropsychopharmacology. 21:1999;106-115.
    • (1999) Neuropsychopharmacology , vol.21 , pp. 106-115
    • Meltzer, H.Y.1
  • 68
    • 0027985385 scopus 로고
    • The pharmacoeconomics of clozapine: A review
    • Meltzer H.Y., Cola P.A. The pharmacoeconomics of clozapine A review . J Clin Psychiatry. 55:(suppl B):1994;161-165.
    • (1994) J Clin Psychiatry , vol.55 , Issue.SUPPL. B , pp. 161-165
    • Meltzer, H.Y.1    Cola, P.A.2
  • 69
    • 0024854809 scopus 로고
    • The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs
    • Meltzer H.Y., Matsubara S., Lee J.C. The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs. Psychopharmacol Bull. 25:1989;390-392.
    • (1989) Psychopharmacol Bull , vol.25 , pp. 390-392
    • Meltzer, H.Y.1    Matsubara, S.2    Lee, J.C.3
  • 70
    • 0032977410 scopus 로고    scopus 로고
    • The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia
    • Meltzer H.Y., McGurk S.R. The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. Schizophr Bull. 25:1999;233-255.
    • (1999) Schizophr Bull , vol.25 , pp. 233-255
    • Meltzer, H.Y.1    McGurk, S.R.2
  • 71
    • 0026357347 scopus 로고
    • Effects of antipsychotic drugs on serotonin receptors
    • Meltzer H.Y., Nash F.J. Effects of antipsychotic drugs on serotonin receptors. Pharmacol Rev. 43:1991;587-604.
    • (1991) Pharmacol Rev , vol.43 , pp. 587-604
    • Meltzer, H.Y.1    Nash, F.J.2
  • 72
    • 0029889615 scopus 로고    scopus 로고
    • The clinical use of clozapine plasma concentrations in the management of treatment-refractory schizophrenia
    • Miller D.D. The clinical use of clozapine plasma concentrations in the management of treatment-refractory schizophrenia. Ann Clin Psychiatry. 8:1996;99-109.
    • (1996) Ann Clin Psychiatry , vol.8 , pp. 99-109
    • Miller, D.D.1
  • 73
    • 0027937972 scopus 로고
    • Plasma clozapine concentrations as a predictor of clinical response: A follow-up study
    • Miller D.D., Fleming F., Holman T.L., et al. Plasma clozapine concentrations as a predictor of clinical response A follow-up study . J Clin Psychiatry. 55:1994;117-121.
    • (1994) J Clin Psychiatry , vol.55 , pp. 117-121
    • Miller, D.D.1    Fleming, F.2    Holman, T.L.3
  • 74
    • 0016332289 scopus 로고
    • Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism
    • Miller R.J., Hiley C.R. Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism. Nature. 248:1974;596-597.
    • (1974) Nature , vol.248 , pp. 596-597
    • Miller, R.J.1    Hiley, C.R.2
  • 75
    • 0033564434 scopus 로고    scopus 로고
    • Prolactin hyperresponsiveness to D-fenfluramine in drug-free schizophrenic patients: A placebo-controlled study
    • Monteleone P., Tortorella A., Borriello R., et al. Prolactin hyperresponsiveness to D-fenfluramine in drug-free schizophrenic patients A placebo-controlled study . Biol Psychiatry. 45:1999;1606-1611.
    • (1999) Biol Psychiatry , vol.45 , pp. 1606-1611
    • Monteleone, P.1    Tortorella, A.2    Borriello, R.3
  • 76
    • 0032929010 scopus 로고    scopus 로고
    • Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: Effect on the CYP1A2 inducibility in humans
    • Nakajima M., Yokoi T., Mizutani M., et al. Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene Effect on the CYP1A2 inducibility in humans . J Biochem (Tokyo). 125:1999;803-808.
    • (1999) J Biochem (Tokyo) , vol.125 , pp. 803-808
    • Nakajima, M.1    Yokoi, T.2    Mizutani, M.3
  • 77
    • 0029670417 scopus 로고    scopus 로고
    • 5-HT2 receptor gene locus: Association with schizophrenia or treatment response not detected
    • Nimgaonkar V.L., Zhang X.R., Brar J.S., et al. 5-HT2 receptor gene locus Association with schizophrenia or treatment response not detected . Psychiatr Genet. 6:1996;23-27.
    • (1996) Psychiatr Genet , vol.6 , pp. 23-27
    • Nimgaonkar, V.L.1    Zhang, X.R.2    Brar, J.S.3
  • 78
    • 0028991822 scopus 로고
    • D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentrations: A PET study of schizophrenia patients
    • Nordstrom A.L., Farde L., Nyberg S., et al. D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentrations A PET study of schizophrenia patients . Am J Psychiatry. 152:1995;1444-1449.
    • (1995) Am J Psychiatry , vol.152 , pp. 1444-1449
    • Nordstrom, A.L.1    Farde, L.2    Nyberg, S.3
  • 79
    • 0029151653 scopus 로고
    • Genetic variation of the 5-HT2A receptor and response to clozapine
    • Nothen M.M., Rietschel M., Erdmann J., et al. Genetic variation of the 5-HT2A receptor and response to clozapine. Lancet. 346:1995;908-909.
    • (1995) Lancet , vol.346 , pp. 908-909
    • Nothen, M.M.1    Rietschel, M.2    Erdmann, J.3
  • 80
    • 0033022950 scopus 로고    scopus 로고
    • Variability in response to clozapine: Potential role of cytochrome P450 1A2 and the dopamine D4 receptor gene
    • Ozdemir V., Masellis M., Basile V.S., et al. Variability in response to clozapine Potential role of cytochrome P450 1A2 and the dopamine D4 receptor gene . CNS Spectrums. 4:1999;30-56.
    • (1999) CNS Spectrums , vol.4 , pp. 30-56
    • Ozdemir, V.1    Masellis, M.2    Basile, V.S.3
  • 81
    • 0003603151 scopus 로고    scopus 로고
    • CYP1A2 activity predicts clozapine steady state concentration in schizophrenic patients (abstract)
    • Ozdemir V., Posner P., Collins E.J., et al. CYP1A2 activity predicts clozapine steady state concentration in schizophrenic patients (abstract). Clin Pharmacol Ther. 65:1999;175.
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 175
    • Ozdemir, V.1    Posner, P.2    Collins, E.J.3
  • 83
    • 0026068791 scopus 로고
    • Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients
    • Perry P.J., Miller D.D., Arndt S.V., et al. Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients. Am J Psychiatry. 148:1991;231-235.
    • (1991) Am J Psychiatry , vol.148 , pp. 231-235
    • Perry, P.J.1    Miller, D.D.2    Arndt, S.V.3
  • 84
    • 0031927741 scopus 로고    scopus 로고
    • Pharmacogenomics and diagnostics
    • Persidis A. Pharmacogenomics and diagnostics. Nat Biotechnol. 16:1998;791-792.
    • (1998) Nat Biotechnol , vol.16 , pp. 791-792
    • Persidis, A.1
  • 85
    • 0027967725 scopus 로고
    • Plasma clozapine and haloperidol concentrations in adolescents with childhood-onset schizophrenia: Association with response
    • Piscitelli S.C., Frazier J.A., McKenna K., et al. Plasma clozapine and haloperidol concentrations in adolescents with childhood-onset schizophrenia association with response . J Clin Psychiatry. 55:1994;94-97.
    • (1994) J Clin Psychiatry , vol.55 , pp. 94-97
    • Piscitelli, S.C.1    Frazier, J.A.2    McKenna, K.3
  • 86
    • 0027942064 scopus 로고
    • Plasma clozapine concentrations predict clinical response in treatment- resistant schizophrenia
    • Potkin S.G., Bera R., Gulasekaram B., et al. Plasma clozapine concentrations predict clinical response in treatment- resistant schizophrenia. J Clin Psychiatry. 55:(suppl B):1994;133-136.
    • (1994) J Clin Psychiatry , vol.55 , Issue.SUPPL. B , pp. 133-136
    • Potkin, S.G.1    Bera, R.2    Gulasekaram, B.3
  • 87
    • 0030827556 scopus 로고    scopus 로고
    • A transmission disequilibrium test for quantitative trait loci
    • Rabinowitz D. A transmission disequilibrium test for quantitative trait loci. Hum Hered. 47:1997;342-350.
    • (1997) Hum Hered , vol.47 , pp. 342-350
    • Rabinowitz, D.1
  • 88
    • 0028172045 scopus 로고
    • Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine
    • Rao P.A., Pickar D., Gejman P.V., et al. Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Arch Gen Psychiatry. 51:1994;912-917.
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 912-917
    • Rao, P.A.1    Pickar, D.2    Gejman, P.V.3
  • 89
    • 0032616971 scopus 로고    scopus 로고
    • Inventing the pharmacogenomics business
    • Regalado A. Inventing the pharmacogenomics business. Am J Health Syst Pharm. 56:1999;40-50.
    • (1999) Am J Health Syst Pharm , vol.56 , pp. 40-50
    • Regalado, A.1
  • 90
    • 0033602828 scopus 로고    scopus 로고
    • Pharmacogenetics in psychosis, the first consensus conference
    • Rietschel M., Kennedy J.L., Macciardi F.M., et al. Pharmacogenetics in psychosis, the first consensus conference. Schizophr Res. 37:1999;191-196.
    • (1999) Schizophr Res , vol.37 , pp. 191-196
    • Rietschel, M.1    Kennedy, J.L.2    Macciardi, F.M.3
  • 91
    • 0030738648 scopus 로고    scopus 로고
    • Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor
    • Rietschel M., Naber D., Fimmers R., et al. Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor. Neuroreport. 8:1997;1999-2003.
    • (1997) Neuroreport , vol.8 , pp. 1999-2003
    • Rietschel, M.1    Naber, D.2    Fimmers, R.3
  • 92
    • 0030296697 scopus 로고    scopus 로고
    • Efficacy and side-effects of clozapine: Testing for association with allelic variation in the dopamine D4 receptor gene
    • Rietschel M., Naber D., Oberlander H., et al. Efficacy and side-effects of clozapine testing for association with allelic variation in the dopamine D4 receptor gene . Neuropsychopharmacology. 15:1996;491-496.
    • (1996) Neuropsychopharmacology , vol.15 , pp. 491-496
    • Rietschel, M.1    Naber, D.2    Oberlander, H.3
  • 93
    • 7344262317 scopus 로고    scopus 로고
    • The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children
    • Rowe D.C., Stever C., Gard J.M., et al. The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. Behav Genet. 28:1998;215-225.
    • (1998) Behav Genet , vol.28 , pp. 215-225
    • Rowe, D.C.1    Stever, C.2    Gard, J.M.3
  • 94
    • 0031658585 scopus 로고    scopus 로고
    • Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder
    • Rowe D.C., Stever C., Giedinghagen L.N., et al. Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder. Mol Psychiatry. 3:1998;419-426.
    • (1998) Mol Psychiatry , vol.3 , pp. 419-426
    • Rowe, D.C.1    Stever, C.2    Giedinghagen, L.N.3
  • 96
    • 0032908778 scopus 로고    scopus 로고
    • Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
    • Sachse C., Brockmoller J., Bauer S., et al. Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol. 47:1999;445-449.
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 445-449
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3
  • 97
    • 0030752950 scopus 로고    scopus 로고
    • Review the role of dopamine D4 receptors in schizophrenia and antipsychotic action
    • Sanyal S., Van Tol H.H. Review the role of dopamine D4 receptors in schizophrenia and antipsychotic action. J Psychiatr Res. 31:1997;219-232.
    • (1997) J Psychiatr Res , vol.31 , pp. 219-232
    • Sanyal, S.1    Van Tol, H.H.2
  • 98
    • 0027408882 scopus 로고
    • Familial differences between rapid neuroleptic response psychosis and delayed neuroleptic response psychosis
    • Sautter F., McDermott B., Garver D. Familial differences between rapid neuroleptic response psychosis and delayed neuroleptic response psychosis. Biol Psychiatry. 33:1993;15-21.
    • (1993) Biol Psychiatry , vol.33 , pp. 15-21
    • Sautter, F.1    McDermott, B.2    Garver, D.3
  • 99
    • 0026481115 scopus 로고
    • Dopamine receptor sequences: Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4
    • Seeman P. Dopamine receptor sequences Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4 . Neuropsychopharmacology. 7:1992;261-284.
    • (1992) Neuropsychopharmacology , vol.7 , pp. 261-284
    • Seeman, P.1
  • 100
    • 0028847305 scopus 로고
    • Deriving the therapeutic concentrations for clozapine and haloperidol: The apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand
    • Seeman P., Van Tol H.H. Deriving the therapeutic concentrations for clozapine and haloperidol The apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand . Eur J Pharmacol. 291:1995;59-66.
    • (1995) Eur J Pharmacol , vol.291 , pp. 59-66
    • Seeman, P.1    Van Tol, H.H.2
  • 101
    • 0032975554 scopus 로고    scopus 로고
    • Factor analysis of delusional disorder symptomatology
    • Serretti A., Lattuada E., Cusin C., et al. Factor analysis of delusional disorder symptomatology. Compr Psychiatry. 40:1999;143-147.
    • (1999) Compr Psychiatry , vol.40 , pp. 143-147
    • Serretti, A.1    Lattuada, E.2    Cusin, C.3
  • 102
    • 0029839896 scopus 로고    scopus 로고
    • Identification of symptomatologic patterns common to major psychoses: Proposal for a phenotype definition
    • Serretti A., Macciardi F., Smeraldi E. Identification of symptomatologic patterns common to major psychoses Proposal for a phenotype definition . Am J Med Genet. 67:1996;393-400.
    • (1996) Am J Med Genet , vol.67 , pp. 393-400
    • Serretti, A.1    Macciardi, F.2    Smeraldi, E.3
  • 103
    • 0027402393 scopus 로고
    • Dopamine D4 receptor subtypes and response to clozapine
    • Shaikh S., Collier D., Kerwin R.W., et al. Dopamine D4 receptor subtypes and response to clozapine. Lancet. 341:1993;116.
    • (1993) Lancet , vol.341 , pp. 116
    • Shaikh, S.1    Collier, D.2    Kerwin, R.W.3
  • 104
    • 0029560535 scopus 로고
    • Analysis of clozapine response and polymorphisms of the dopamine D4 receptor gene (DRD4) in schizophrenic patients
    • Shaikh S., Collier D.A., Sham P., et al. Analysis of clozapine response and polymorphisms of the dopamine D4 receptor gene (DRD4) in schizophrenic patients. Am J Med Genet (Neuropsychiatr Genet). 60:1995;541-545.
    • (1995) Am J Med Genet (Neuropsychiatr Genet) , vol.60 , pp. 541-545
    • Shaikh, S.1    Collier, D.A.2    Sham, P.3
  • 105
    • 0030005962 scopus 로고    scopus 로고
    • Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia
    • Shaikh S., Collier D.A., Sham P.C., et al. Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia. Hum Genet. 97:1996;714-719.
    • (1996) Hum Genet , vol.97 , pp. 714-719
    • Shaikh, S.1    Collier, D.A.2    Sham, P.C.3
  • 106
    • 0016134852 scopus 로고
    • Antischizophrenic drugs: Affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effects
    • Snyder S.H., Greenberg D., Yamumura H.I. Antischizophrenic drugs Affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effects . J Psychiatr Res. 11:1974;91-95.
    • (1974) J Psychiatr Res , vol.11 , pp. 91-95
    • Snyder, S.H.1    Greenberg, D.2    Yamumura, H.I.3
  • 107
    • 0029551796 scopus 로고
    • Association between clozapine response and allelic variation in the 5-HT2C receptor gene
    • Sodhi M.S., Arranz M.J., Curtis D., et al. Association between clozapine response and allelic variation in the 5-HT2C receptor gene. Neuroreport. 7:1995;169-172.
    • (1995) Neuroreport , vol.7 , pp. 169-172
    • Sodhi, M.S.1    Arranz, M.J.2    Curtis, D.3
  • 108
    • 0030797854 scopus 로고    scopus 로고
    • Pharmacokinetic interactions involving clozapine
    • Taylor D. Pharmacokinetic interactions involving clozapine. Br J Psychiatry. 171:1997;109-112.
    • (1997) Br J Psychiatry , vol.171 , pp. 109-112
    • Taylor, D.1
  • 109
    • 0029064537 scopus 로고
    • Mapping disease genes: Family-based association studies
    • Thomson G. Mapping disease genes Family-based association studies . Am J Hum Genet. 57:1995;487-498.
    • (1995) Am J Hum Genet , vol.57 , pp. 487-498
    • Thomson, G.1
  • 110
    • 0026427253 scopus 로고
    • Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
    • Van Tol H.H., Bunzow J.R., Guan H.C., et al. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature. 350:1991;610-614.
    • (1991) Nature , vol.350 , pp. 610-614
    • Van Tol, H.H.1    Bunzow, J.R.2    Guan, H.C.3
  • 111
    • 0029903903 scopus 로고    scopus 로고
    • Response of patients with treatment-refractory schizophrenia to clozapine within three serum level ranges
    • VanderZwaag C., McGee M., McEvoy J.P., et al. Response of patients with treatment-refractory schizophrenia to clozapine within three serum level ranges. Am J Psychiatry. 153:1996;1579-1584.
    • (1996) Am J Psychiatry , vol.153 , pp. 1579-1584
    • Vanderzwaag, C.1    McGee, M.2    McEvoy, J.P.3
  • 112
    • 13344278706 scopus 로고    scopus 로고
    • Monozygotic twins concordant for response to clozapine
    • Vojvoda D., Grimmell K., Sernyak M., et al. Monozygotic twins concordant for response to clozapine. Lancet. 347:1996;61.
    • (1996) Lancet , vol.347 , pp. 61
    • Vojvoda, D.1    Grimmell, K.2    Sernyak, M.3
  • 113
    • 0031963522 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of clozapine with selective serotonin reuptake inhibitors: Differential effects of fluvoxamine and paroxetine in a prospective study
    • Wetzel H., Anghelescu I., Szegedi A., et al. Pharmacokinetic interactions of clozapine with selective serotonin reuptake inhibitors Differential effects of fluvoxamine and paroxetine in a prospective study . J Clin Psychopharmacol. 18:1998;2-9.
    • (1998) J Clin Psychopharmacol , vol.18 , pp. 2-9
    • Wetzel, H.1    Anghelescu, I.2    Szegedi, A.3
  • 114
    • 0033606080 scopus 로고    scopus 로고
    • Serotonin-6 receptor variant (C267T) and clinical response to clozapine
    • Yu Y.W., Tsai S.J., Lin C.H., et al. Serotonin-6 receptor variant (C267T) and clinical response to clozapine. Neuroreport. 10:1999;1231-1233.
    • (1999) Neuroreport , vol.10 , pp. 1231-1233
    • Yu, Y.W.1    Tsai, S.J.2    Lin, C.H.3


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