The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children

Behavior Genetics

Volumn 28, Issue 3, 1998, Pages 215-225

  Rowe, David C ^a   Stever, Craig ^a   Gard, Jaime M C ^a   Cleveland, Hobart H ^a   Sanders, Matthew L ^a   Abramowitz, Ann ^b   Kozol, Susan T ^c   Mohr, Jennifer H ^c   Sherman, Stephanie L ^c   Waldman, Irwin D ^c  

^a UNIVERSITY OF ARIZONA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

Anxiety; DAT1; Dopamine transporter; Genetics; Internalizing traits; Phobias

Indexed keywords

DOPAMINE TRANSPORTER;

ADOLESCENT; ADULT; ALLELE; ANXIETY; ARTICLE; BEHAVIOR GENETICS; COMORBIDITY; DOPAMINERGIC SYSTEM; FEMALE; GENE ACTIVITY; GENETIC ANALYSIS; GENETICS; GENOTYPE; GILLES DE LA TOURETTE SYNDROME; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSESSION; PHOBIA; PSYCHIATRIC DIAGNOSIS; RECEPTOR GENE;

ADOLESCENT; ANXIETY DISORDERS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CARRIER PROTEINS; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHILD; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FAMILY HEALTH; FEMALE; GENOTYPE; HUMANS; LINEAR MODELS; LINKAGE DISEQUILIBRIUM; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NUCLEAR FAMILY; QUANTITATIVE TRAIT, HERITABLE; TOURETTE SYNDROME;

EID: 7344262317     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021427314941     Document Type: Article

References (26)

1. Allison, D. B. (1997). Transmission-disequilibrium tests for quantitative traits. Am. J. Hum. Genet. 60:676-690.
2. Blum, K., Cull, J. G., Braverman, E. R., and Comings, D. E. (1996). Reward deficiency syndrome. Am. Sci. 84:132-145.
3. Comings, D. E., Comings, B. G., and Knell, E. (1989). Hypothesis: Homozygosity in Tourette syndrome. Am. J. Med. Genet. 34:413-421.
4. Comings, D. E., Wu, S., Chiu, C., Ring, R. H., Gade, R., Ahn, C., MacMurray, J. P., Dietz, G., and Muhleman, D. (1996). Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: The additive and subtractive effect of three dopaminergic genes - DRD2, DβH, and DAT1. Am. J. Med. Genet. (Neuropsychiatric Genetics) 67:264-288.
5. Cook, E. H., Stein, M. A., Krasowski, M. D., Cox, N. J., Olkon, D. M., Kieffer, J. E., and Leventhal, B. L. (1995). Association of attention-deficit disorder and the dopamine transporter gene. Am. J. Hum. Genet. 56:993-998.
6. Deater-Deckard, K., Reiss, D., Hetherington, E. M., and Plomin, R. (1997). Dimensions and disorders of adolescent adjustment: A quantitative genetic analysis of unselected samples and selected extremes. J. Child Psychol. Psychiatry 38:515-525.
7. Doucette-Stamm, L. A., Blakely, D. J., Tian, J., Mockus, S., and Mao, J. (1995). Population study of the human dopamine transporter gene (DAT1). Genet. Epidemiol. 12: 303-308.
8. Fergusson, D. M., Horwood, L. J., and Lynskey, M. T. (1993). Prevalence and comorbidity of DSM-III-R diagnoses in a birth cohort of 15 year olds. J. Am. Acad. Child Adolesc. Psychiatry 32:1127-1134.
9. Gill, M., Galy, G., Heron, S., Hawl, Z., and Fitzgerald, M. (1997). Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol. Psychiatry 2:311-313.
10. Giros, B., Jabar, M., Jones, S. R., Wightman, R. M., and Caron, M. G. (1996). Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612.
11. Goodwin, E. B., Okkema, P. G., Evans, T. C., and Kimble, J. (1993). Translational regulation of tra-2 by its 3' untranslated region controls sexual identity in C. elegans. Cell 75:329-339.
12. Hinshaw, S. P. (1994). Attention Deficits and Hyperactivity in Children, Sage, Thousand Oaks, CA.
13. Kendler, K., Neale, M. C., Kessler, R. C., and Heath, A. C. (1992). Major depression and generalized anxiety disorder: Same genes, partly different environments. Arch. Gen. Psychiatry 49:716-722.
14. Kendler, K., Neale, M. C., Kessler, R. C., Heath, A. C., and Eaves, L. J. (1993). Major depression and phobias: The genetic and environmental sources of comorbidity. Psychol. Med. 23:361-371.
15. LaHoste, D. J., Wigal, S. B., Glade, C., Cook, E. H., Kennedy, J. L., and Swanson, J. M. (1995). Dopamine related genes and ADHD disorder. Paper presented at the meeting of the Society for Neurociences, San Diego.
16. Malison, R. T., McDougle, C. J., van Dyck, C. H., Scahill, L., Baldwin, R. M., Seibyl, J. P., Price, L. H., Leckman, J. F., and Innis, R. B. (1995). [123I]B-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder. Am. J. Psychiatry 152:1359-1361.
17. Neale, M. C., and Kendler, K. S. (1995). Multifactorial models of comorbidity. Am. J. Hum. Genet. 57:935-953.
18. Nakatome, M., Honda, K., Islam, M. N., Terada, M., Yamazaki, M., Kuroki, H., Ogura, Y., Bai, H., and Wakasugi, C. (1995). Amplification of DAT1 (human dopamine transporter gene) 3' variable region in the Japanese population. Hum. Hered. 45:262-265.
19. Ritz, M. C., Lamb, R. J., Goldberg, S. R., and Kuhar, M. J. (1987). Cocaine receptors on the dopamine transporters are related to self-administration of cocaine. Science 237: 1219-1223.
20. Schweri, M. M., Thurkauf, A., Mattson, M. V., and Rice, K. C. (1992). Fourphit: A selective probe for the methyl-phenidate binding site on the dopamine transporter. J. Pharmacol. Exp. Ther. 261:936-942.
21. Singer, H., Hahn, I., and Moran, T. (1991). Tourette's syndrome: Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome. Ann. Neural. 30:558-562.
22. Spielman, R. S., and Ewens, W. J. (1996). The TDT and other family-based tests for linkage disequilibrium and association. Am. J. Hum. Genet. 59:983-989.
23. Spielman, R. S., McGinnis, R. E., and Ewens, W. J. (1993). Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent mellitus (IDDM). Am. J. Hum. Genet. 52:506-516.
24. Vandenberg, D. J., Persico, A. M., Hawkins, A. L., Griffin, C. A., Li, X., Jabs, E. W., and Uhl, G. R. (1992). Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics 14:1866-1868.
25. Verhulst, F. C., and van der Ende, J. (1993). "Comorbidity" in an epidemiological sample: A longitudinal perspective. J. Child Psychol. Psychiatry 34:767-783.
26. Waldman, I. D., Rowe, D. C., Abramowitz, A., Kozel, S., Mohr, J., Sherman, S. L., Cleveland, H. H., Sanders, M. L., and Stever, C. (1998). Association and linkage of the dopamine transporter gene (DAT1) and attention deficit hyperactivity disorder in children. (submitted for publication).