메뉴 건너뛰기




Volumn 45, Issue 5, 1999, Pages 544-550

Benefits and pitfalls encountered in psychiatric genetic association studies

Author keywords

Allele; Association; Gene; Genetics; Polymorphism; Psychiatry

Indexed keywords

ALLELE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME; MENTAL DISEASE; PERSONALITY DISORDER; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

EID: 0033106068     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00365-5     Document Type: Review
Times cited : (83)

References (48)
  • 1
    • 0031037951 scopus 로고    scopus 로고
    • A photoreceptor cell-specific ATP-binding transporter gene (ACBR) is mutated in recessive Stargardt macular dystrophy
    • Allikmets R, Singh N, Sun H, Shroyer NF, Hutchinson A, Chidambaram A, et al (1997): A photoreceptor cell-specific ATP-binding transporter gene (ACBR) is mutated in recessive Stargardt macular dystrophy. Nature Genet 15:236-246.
    • (1997) Nature Genet , vol.15 , pp. 236-246
    • Allikmets, R.1    Singh, N.2    Sun, H.3    Shroyer, N.F.4    Hutchinson, A.5    Chidambaram, A.6
  • 3
    • 0030033685 scopus 로고    scopus 로고
    • Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking
    • Benjamin J, Greenberg B, Murphy DL, Lin L, Patterson C, Hamer DH (1996): Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nature Genet 12:81-84.
    • (1996) Nature Genet , vol.12 , pp. 81-84
    • Benjamin, J.1    Greenberg, B.2    Murphy, D.L.3    Lin, L.4    Patterson, C.5    Hamer, D.H.6
  • 5
    • 0027442475 scopus 로고
    • Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
    • Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA (1993): Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262(5133):578-580.
    • (1993) Science , vol.262 , Issue.5133 , pp. 578-580
    • Brunner, H.G.1    Nelen, M.2    Breakefield, X.O.3    Ropers, H.H.4    Van Oost, B.A.5
  • 6
    • 0033106050 scopus 로고    scopus 로고
    • Basic Concepts in the study of diseases with complex genetics
    • Burmeister M (1999): Basic Concepts in the study of diseases with complex genetics. Biol Psychiatry 45:522-532.
    • (1999) Biol Psychiatry , vol.45 , pp. 522-532
    • Burmeister, M.1
  • 7
    • 0029942216 scopus 로고    scopus 로고
    • The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus
    • Chang FM, Kidd JR, Livak KJ, Pakstis AJ, Kidd KK (1996): The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet 98(1):91-101.
    • (1996) Hum Genet , vol.98 , Issue.1 , pp. 91-101
    • Chang, F.M.1    Kidd, J.R.2    Livak, K.J.3    Pakstis, A.J.4    Kidd, K.K.5
  • 8
    • 10244219858 scopus 로고    scopus 로고
    • Accessing genetic information with high-density DNA arrays
    • Chee M, Yang R, Hubbell E, Berno A, Huang XC, Stern D, et al (1996): Accessing genetic information with high-density DNA arrays. Science 274:610-614.
    • (1996) Science , vol.274 , pp. 610-614
    • Chee, M.1    Yang, R.2    Hubbell, E.3    Berno, A.4    Huang, X.C.5    Stern, D.6
  • 9
    • 8244234472 scopus 로고    scopus 로고
    • Evidence of linkage between the serotonin transporter and autistic disorder
    • Cook EH, Courchesne R, Lord C, Cox NJ, Yan S, Lincoln A, et al (1997): Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 2:224-226.
    • (1997) Mol Psychiatry , vol.2 , pp. 224-226
    • Cook, E.H.1    Courchesne, R.2    Lord, C.3    Cox, N.J.4    Yan, S.5    Lincoln, A.6
  • 10
    • 0001633495 scopus 로고    scopus 로고
    • Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene
    • Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, et al (1996): Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856-1862.
    • (1996) Science , vol.273 , pp. 1856-1862
    • Dean, M.1    Carrington, M.2    Winkler, C.3    Huttley, G.A.4    Smith, M.W.5
  • 12
    • 0028157902 scopus 로고
    • No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia
    • Gejman PV, Ram A, Gelernter J, Friedman E, Cao Q, Pickar D, et al (1994): No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. JAMA 271: 204-208.
    • (1994) JAMA , vol.271 , pp. 204-208
    • Gejman, P.V.1    Ram, A.2    Gelernter, J.3    Friedman, E.4    Cao, Q.5    Pickar, D.6
  • 15
    • 0027322393 scopus 로고
    • DRD2 dopamine receptor genotype, linkage disequilibrium and alcoholism in American Indians and other populations
    • Goldman D, Brown GL, Albaugh B, Robin R, Goodson S, Trunzo M, et al (1993): DRD2 dopamine receptor genotype, linkage disequilibrium and alcoholism in American Indians and other populations. Alcohol Clin Exp Res 17:199-204.
    • (1993) Alcohol Clin Exp Res , vol.17 , pp. 199-204
    • Goldman, D.1    Brown, G.L.2    Albaugh, B.3    Robin, R.4    Goodson, S.5    Trunzo, M.6
  • 16
    • 0030749559 scopus 로고    scopus 로고
    • The dopamine D2 receptor: Linkage and association of a functional allele [Ser311Cys] and other D2DR markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians
    • Goldman D, Urbanek M, Guenther D, Robin R, Long UC (1997): The dopamine D2 receptor: Linkage and association of a functional allele [Ser311Cys] and other D2DR markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians. Neuropsychiatric Genetics 74:386-394.
    • (1997) Neuropsychiatric Genetics , vol.74 , pp. 386-394
    • Goldman, D.1    Urbanek, M.2    Guenther, D.3    Robin, R.4    Long, U.C.5
  • 17
    • 0024474112 scopus 로고
    • The human dopamine D2 receptor gene is located on chromosome 11 at q22-q23 and identifies a TaqI RFLP
    • Grandy DK, Litt M, Allen L, Bunzow JR, Marchionni M, Makam H (1989): The human dopamine D2 receptor gene is located on chromosome 11 at q22-q23 and identifies a TaqI RFLP. Am J Hum Genet 45(5):778-785.
    • (1989) Am J Hum Genet , vol.45 , Issue.5 , pp. 778-785
    • Grandy, D.K.1    Litt, M.2    Allen, L.3    Bunzow, J.R.4    Marchionni, M.5    Makam, H.6
  • 19
    • 0005350530 scopus 로고
    • Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese
    • Harada S, Agarwal DP, Goedde HW (1981): Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet 2(8253):982.
    • (1981) Lancet , vol.2 , Issue.8253 , pp. 982
    • Harada, S.1    Agarwal, D.P.2    Goedde, H.W.3
  • 20
    • 0027528480 scopus 로고
    • Attention deficit-hyperactivity disorder in people with generalized resistance to thyroid hormone
    • Hauser P, Zametkin AJ, Martinez P, Vitiello B, Matochik JA, Mixson AJ, et al (1993): Attention deficit-hyperactivity disorder in people with generalized resistance to thyroid hormone. N Engl J Med 328(14):997-1001.
    • (1993) N Engl J Med , vol.328 , Issue.14 , pp. 997-1001
    • Hauser, P.1    Zametkin, A.J.2    Martinez, P.3    Vitiello, B.4    Matochik, J.A.5    Mixson, A.J.6
  • 22
    • 0006463359 scopus 로고    scopus 로고
    • Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
    • Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al (1996): Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
    • (1996) Science , vol.274 , pp. 1527-1531
    • Lesch, K.P.1    Bengel, D.2    Heils, A.3    Sabol, S.Z.4    Greenberg, B.D.5    Petri, S.6
  • 23
    • 0028913523 scopus 로고
    • An E-M algorithm and testing strategy for multiple-locus haplotypes
    • Long JC, Williams RC, Urbanek M (1995): An E-M algorithm and testing strategy for multiple-locus haplotypes. Am J Hum Genet 56(3):799-810.
    • (1995) Am J Hum Genet , vol.56 , Issue.3 , pp. 799-810
    • Long, J.C.1    Williams, R.C.2    Urbanek, M.3
  • 24
    • 0031822689 scopus 로고    scopus 로고
    • A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics
    • Malhotra AK, Goldman D, Mazzanti C, Clifton A, Breier A, Pickar D (1998): A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics. Mol Psychiatry 3:328-332.
    • (1998) Mol Psychiatry , vol.3 , pp. 328-332
    • Malhotra, A.K.1    Goldman, D.2    Mazzanti, C.3    Clifton, A.4    Breier, A.5    Pickar, D.6
  • 29
    • 0026608061 scopus 로고
    • Differential expression of c-fos and zip268 in rat striatum after haloperidol, clozapine, and amphetamine
    • Nguyen TV, Kosofsky BE, Birnbaum R, Cohen BM, Hyman SE (1992): Differential expression of c-fos and zip268 in rat striatum after haloperidol, clozapine, and amphetamine. Proc Natl Acad Sci 89(10):4270-4274.
    • (1992) Proc Natl Acad Sci , vol.89 , Issue.10 , pp. 4270-4274
    • Nguyen, T.V.1    Kosofsky, B.E.2    Birnbaum, R.3    Cohen, B.M.4    Hyman, S.E.5
  • 31
    • 0022422655 scopus 로고
    • Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis
    • Myers RM, Fischer SG, Lerman LS, Maniatis T (1985): Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucleic Acids Res 13:3131-3145.
    • (1985) Nucleic Acids Res , vol.13 , pp. 3131-3145
    • Myers, R.M.1    Fischer, S.G.2    Lerman, L.S.3    Maniatis, T.4
  • 32
    • 0024756969 scopus 로고
    • Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
    • Orita M, Suzuki Y, Seyiya T, Hayashi K (1989): Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5(4): 874-879.
    • (1989) Genomics , vol.5 , Issue.4 , pp. 874-879
    • Orita, M.1    Suzuki, Y.2    Seyiya, T.3    Hayashi, K.4
  • 35
    • 0028340175 scopus 로고
    • The genetic basis of complex human behaviors
    • Plomin R, Owen MJ, McGuffin P (1994): The genetic basis of complex human behaviors. Science 264:1733-1739.
    • (1994) Science , vol.264 , pp. 1733-1739
    • Plomin, R.1    Owen, M.J.2    McGuffin, P.3
  • 36
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K (1996): The future of genetic studies of complex human diseases. Science 273:1516-1517.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 37
    • 0031943648 scopus 로고    scopus 로고
    • Role of serotonin transporter promoter repeat length polymorphism (5-HTTEPR) in seasonality and seasonal affective disorder
    • Rosenthal NE, Mazzanti CM, Barnett RL, Hardin TA, Turner EH, Lam GK, et al (1998): Role of serotonin transporter promoter repeat length polymorphism (5-HTTEPR) in seasonality and seasonal affective disorder. Mol Psychiatry 3:175-177.
    • (1998) Mol Psychiatry , vol.3 , pp. 175-177
    • Rosenthal, N.E.1    Mazzanti, C.M.2    Barnett, R.L.3    Hardin, T.A.4    Turner, E.H.5    Lam, G.K.6
  • 38
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, et al (1996): Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722-725.
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3    Rucker, J.4    Liesnard, C.5
  • 39
    • 0014222377 scopus 로고
    • Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis
    • Seegmiller JE, Rosenbloom FM, Kelley WN (1967): Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. Science 155:1682-1684.
    • (1967) Science , vol.155 , pp. 1682-1684
    • Seegmiller, J.E.1    Rosenbloom, F.M.2    Kelley, W.N.3
  • 40
    • 0030861904 scopus 로고    scopus 로고
    • Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression
    • Smith MW, Dean M, Carrington M, Winkler C, Huttley GA, Lomb DA, et al (1997): Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Science 277:959-965.
    • (1997) Science , vol.277 , pp. 959-965
    • Smith, M.W.1    Dean, M.2    Carrington, M.3    Winkler, C.4    Huttley, G.A.5    Lomb, D.A.6
  • 41
    • 0029551796 scopus 로고
    • Association between clozapine response and allelic variation in the 5-HT2C receptor gene
    • Sodhi MS, Arranz MJ, Curtis D, Ball DM, Sham P, Roberts GW, et al (1995): Association between clozapine response and allelic variation in the 5-HT2C receptor gene. NeuroReport 7:169-172.
    • (1995) NeuroReport , vol.7 , pp. 169-172
    • Sodhi, M.S.1    Arranz, M.J.2    Curtis, D.3    Ball, D.M.4    Sham, P.5    Roberts, G.W.6
  • 42
    • 0029858544 scopus 로고    scopus 로고
    • The TDT and other family-based tests for linkage disequilibrium and association
    • Spielman RS, Ewens WJ (1996): The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59:983-989.
    • (1996) Am J Hum Genet , vol.59 , pp. 983-989
    • Spielman, R.S.1    Ewens, W.J.2
  • 43
    • 0023425198 scopus 로고
    • A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. I. Basic theory and an analysis of alcohol dehydrogenase activity in Drosophila
    • Templeton AR, Boerwinkle E, Sing CF (1987): A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. I. Basic theory and an analysis of alcohol dehydrogenase activity in Drosophila. Genetics 117(2):343-351.
    • (1987) Genetics , vol.117 , Issue.2 , pp. 343-351
    • Templeton, A.R.1    Boerwinkle, E.2    Sing, C.F.3
  • 44
    • 0026494911 scopus 로고
    • A haplotype-based "Haplotype Relative Risk" approach to detecting allelic associations
    • Terwilliger J, Ott J (1992): A haplotype-based "Haplotype Relative Risk" approach to detecting allelic associations. Hum Hered 42:337-346.
    • (1992) Hum Hered , vol.42 , pp. 337-346
    • Terwilliger, J.1    Ott, J.2
  • 45
    • 0022350960 scopus 로고
    • Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker
    • Tsui LC, Buchwald M, Barker D, Braman JC, Knowlton R, Schumm JW, et al (1985): Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker. Science 230(4729):1054-1057.
    • (1985) Science , vol.230 , Issue.4729 , pp. 1054-1057
    • Tsui, L.C.1    Buchwald, M.2    Barker, D.3    Braman, J.C.4    Knowlton, R.5    Schumm, J.W.6
  • 46
    • 0030660620 scopus 로고    scopus 로고
    • Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography
    • Underbill PA, Jin L, Lin AA, Medhi SQ, Jenkins T, Vollrath D, et al (1997): Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography. Genome Res 7(10):996-1005.
    • (1997) Genome Res , vol.7 , Issue.10 , pp. 996-1005
    • Underbill, P.A.1    Jin, L.2    Lin, A.A.3    Medhi, S.Q.4    Jenkins, T.5    Vollrath, D.6
  • 47
    • 6844222858 scopus 로고    scopus 로고
    • A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia
    • Williams J, Spurlock G, Holmans P, Mant R, Murphy K, Jones L, et al (1998): A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry 3:141-149.
    • (1998) Mol Psychiatry , vol.3 , pp. 141-149
    • Williams, J.1    Spurlock, G.2    Holmans, P.3    Mant, R.4    Murphy, K.5    Jones, L.6
  • 48
    • 7144225541 scopus 로고    scopus 로고
    • Genetic restriction of AIDS pathogenesis by an SDF1 chemokine gene mutation
    • Winkler C, Modi W, Smith MW, Nelson GW, Wu X, Carrington M, et al (1998): Genetic restriction of AIDS pathogenesis by an SDF1 chemokine gene mutation. Science 279:389-393.
    • (1998) Science , vol.279 , pp. 389-393
    • Winkler, C.1    Modi, W.2    Smith, M.W.3    Nelson, G.W.4    Wu, X.5    Carrington, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.