Lack of association between the T→C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia

Schizophrenia Research

Volumn 47, Issue 1, 2001, Pages 49-58

  Masellis, Mario ^a   Basile, Vincenzo S ^a   Meltzer, Herbert Y ^b   Lieberman, Jeffrey A ^c   Sevy, Serge ^d   Goldman, David A ^e   Hamblin, Mark W ^f   Macciardi, Fabio M ^a   Kennedy, James L ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Clozapine response; Pharmacogenetic; Polymorphism; Serotonin receptor

Indexed keywords

CLOZAPINE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN 7 RECEPTOR;

ALLELE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; ETHNOLOGY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECEPTOR GENE; SCHIZOPHRENIA; TREATMENT OUTCOME;

ADULT; ALLELES; AMINO ACID SUBSTITUTION; CLOZAPINE; FEMALE; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROGNOSIS; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, SEROTONIN; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TREATMENT OUTCOME;

EID: 0035863032     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(00)00016-5     Document Type: Article

References (63)

1. Association between clozapine response and allelic variation in 5-HT2A receptor gene
2. Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine
3. Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine
4. Pharmacological actions of the atypical antipsychotic drug clozapine: A review
5. Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia
6. Sleep in psychiatric disorders
7. The role of 5-HT1a autoreceptors and alpha 1-adrenoceptors in the modulation of 5-HT release - III. Clozapine and the novel putative antipsychotic S 16924
8. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
9. Dinucleotide repeat and alu repeat polymorphisms at the 5-HT1A (HTR1A) receptor gene
10. Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics and obsessive-compulsive behavior
11. Effect of metergoline, fenfluramine, and 8-OHDPAT on catalepsy induced by haloperidol or morphine
12. The effect of 8-OH DPAT on haloperidol-induced dystonia in non-human primates
13. Extrapyramidal syndromes: Primate models as predictors of clinical response
14. The 5-HT7 receptor: Orphan found
15. Systematic screening for mutations in the promoter and the coding region of the 5-HT1A gene
16. The human serotonin 7 (5-HT7) receptor gene: Genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder
17. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome
18. Clozapine: Selective labeling of sites resembling 5HT6 serotonin receptors may reflect psychoactive profile
19. The effect of serotonergic agents on haloperidol-induced catalepsy
20. International union of pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)
21. HTR1A pro16/leu16 polymorphism in bipolar affective disorder
22. 8-Hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin1A receptor agonist, blocks haloperidol-induced catalepsy by an action on raphe nuclei medianus and dorsalis
23. Clozapine for the treatment-resistant schizophrenic: A double-blind comparison with chlorpromazine
24. Serotonin-dopamine interaction and its relevance to schizophrenia
25. A Sac I RFLP is detected with the 5-HT1a serotonin receptor probe G21
26. Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor
27. Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucelus accumbens
28. A rapid non-enzymatic method for the preparation of HMV DNA from blood for RFLP studies
29. A serotonin receptor gene (5HT1A) variant found in a Tourette's syndrome patient
30. Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: No evidence for reciprocal 5-HT-dopamine interaction
31. No evidence for association of serotonin-2A receptor variant (102 T/C) with schizophrenia or clozapine response in a Chinese population
32. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythyms
33. Lack of associaton between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine
34. Clozapine response and the 5HT(2C)Cys(23)Ser polymorphism
35. Genetic variation of 5-HT2A receptor and response to clozapine
36. Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients
37. Pharmacogenetics of antipsychotic treatment: Lessons learned from clozapine
38. Genetic basis of schizophrenia
39. A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to dna loci D5S6, D5S39 and D5S76
40. An overview of the mechanism of action of clozapine
41. Role of serotonin in the action of atypical antipsychotic drugs
42. Predictors of response to clozapine
43. The role of serotonin in antipsychotic drug action
44. Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: Glycine 22 to serine 22 and isoleucine 28 to valine 28
45. Serotonergic involvement in haloperidol-induced catalepsy
46. Clozapine is a partial agonist at cloned, human serotonin 5-HT1A receptors
47. Genetic variation of the 5-HT2A receptor and response to clozapine
48. Variability in response to clozapine: Potential role of cytochrome P450 1A2 and the dopamine D4 receptor gene
49. Rare non-conservative amino acid substitution in the 5-HT7 receptor gene found in alcoholics with antisocial personality disorder
50. Mutation screening of the 5-hydroxytryptamine7 receptor gene among Finnish alcoholics and controls
51. Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor
52. Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation
53. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors
54. Association between clozapine response and allelic variation in the 5-HT2C receptor gene
55. Modification of haloperidol-induced pattern of c-fos expression by serotonin
56. Antagonism by 8-OH-DPAT, but not ritanserin, of catalepsy induced by SCH 23390 in the rat
57. Antipsychotic-like profile of combined treatment with raclopride and 8-OH-DPAT in the rat: Enhancement of antipsychotic-like effects without catalepsy
58. An RsaI polymorphism in the human serotonin receptor gene (HTR1A): Detection by DGGE and RFLP analysis
59. The gene encoding the 5-HT1A receptor is intact in mood disorders
60. 5-HT7 receptors mediate serotonergic effects on light-sensitive suprachiasmatic nucleus neurons
61. Serotonin-6 receptor variant (C267T) and clinical response to clozapine