메뉴 건너뛰기




Volumn 16, Issue 2, 1996, Pages 177-187

Pharmacokinetics of clozapine and risperidone: A review of recent literature

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; CYTOCHROME P450; DRUG METABOLITE; RISPERIDONE;

EID: 0009404019     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004714-199604000-00010     Document Type: Review
Times cited : (125)

References (78)
  • 1
    • 0003100133 scopus 로고
    • What makes a neuroleptic atypical?
    • Meltzer HY, ed. New York: Raven Press, Ltd
    • Casey DE. What makes a neuroleptic atypical? In: Meltzer HY, ed. Novel antipsychotic drugs. New York: Raven Press, Ltd, 1992: 241-51.
    • (1992) Novel Antipsychotic Drugs , pp. 241-251
    • Casey, D.E.1
  • 3
    • 0024466603 scopus 로고
    • Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values
    • Meltzer HY, Matsubara S, Lee J-C. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther 1989;251: 238-46.
    • (1989) J Pharmacol Exp Ther , vol.251 , pp. 238-246
    • Meltzer, H.Y.1    Matsubara, S.2    Lee, J.-C.3
  • 5
    • 0023812652 scopus 로고
    • Clozapine for the treatment-resistant schizophrenic: A double-blind comparison with chlorpromazine
    • the Clozaril Collaborative Study Group
    • Kane J, Honigfeld G, Singer J, Meltzer H, the Clozaril Collaborative Study Group. Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine. Arch Gen Psychiatry 1988;45:489-96.
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 489-496
    • Kane, J.1    Honigfeld, G.2    Singer, J.3    Meltzer, H.4
  • 10
    • 0024425468 scopus 로고
    • Leponex-associated granulocytopenia: A review of the situation
    • Krupp P, Barnes P. Leponex-associated granulocytopenia: a review of the situation. Psychopharmacology (Berl) 1989;99 [suppl]:118-21.
    • (1989) Psychopharmacology (Berl) , vol.99 , Issue.SUPPL. , pp. 118-121
    • Krupp, P.1    Barnes, P.2
  • 11
    • 0028305355 scopus 로고
    • Seizures associated with clozapine treatment in a state hospital
    • Wilson WH, Claussen AM. Seizures associated with clozapine treatment in a state hospital. J Clin Psychiatry 1994;55:184-8.
    • (1994) J Clin Psychiatry , vol.55 , pp. 184-188
    • Wilson, W.H.1    Claussen, A.M.2
  • 14
    • 0025599851 scopus 로고
    • Clozapine: A review of its pharmacological properties, and therapeutic use in schizophrenia
    • Fitton A, Heel R. Clozapine: a review of its pharmacological properties, and therapeutic use in schizophrenia Drugs 1990;40:722-47.
    • (1990) Drugs , vol.40 , pp. 722-747
    • Fitton, A.1    Heel, R.2
  • 18
    • 0346820278 scopus 로고
    • Clozapine
    • Goldberg M, ed. Washington, DC: American Pharmaceutical Association and Academy of Pharmaceutical Sciences
    • Sayers A, Amsler H. Clozapine. In: Goldberg M, ed. Pharmacological, biochemical properties of drug substances. Washington, DC: American Pharmaceutical Association and Academy of Pharmaceutical Sciences, 1977:1-31.
    • (1977) Pharmacological, Biochemical Properties of Drug Substances , pp. 1-31
    • Sayers, A.1    Amsler, H.2
  • 19
    • 0024461513 scopus 로고
    • Clozapine - Pharmacokinetic investigations, biochemical effects in man
    • Ackenheil M, Clozapine - pharmacokinetic investigations, biochemical effects in man. Psychopharmacology (Berl) 1989; 99[suppl]:32-7.
    • (1989) Psychopharmacology (Berl) , vol.99 , Issue.SUPPL. , pp. 32-37
    • Ackenheil, M.1
  • 20
    • 0023677666 scopus 로고
    • Determination of clozapine and its N-desmethylated metabolite in plasma by use of gas chromatography-mass spectrometry with single ion detection
    • Bondesson U, Lindstrom L. Determination of clozapine and its N-desmethylated metabolite in plasma by use of gas chromatography-mass spectrometry with single ion detection. Psychopharmacology (Berl) 1988;95:472-5.
    • (1988) Psychopharmacology (Berl) , vol.95 , pp. 472-475
    • Bondesson, U.1    Lindstrom, L.2
  • 22
    • 0028307888 scopus 로고
    • Disposition of clozapine in man: Lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms
    • Dahl M-L, Llerena A, Bondesson U, Lindstrom L, Bertilsson L. Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms. Br J Clin Pharmacol 1994;37:71-4.
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 71-74
    • Dahl, M.-L.1    Llerena, A.2    Bondesson, U.3    Lindstrom, L.4    Bertilsson, L.5
  • 23
    • 9244262345 scopus 로고
    • A comparison of clozapine absorption in the postprandial versus fasting states
    • Crismon ML, Ereshefsky L, Saklad S. A comparison of clozapine absorption in the postprandial versus fasting states. Pharm Res 1988;5[suppl]:171.
    • (1988) Pharm Res , vol.5 , Issue.SUPPL. , pp. 171
    • Crismon, M.L.1    Ereshefsky, L.2    Saklad, S.3
  • 29
    • 9244256670 scopus 로고
    • Pharmacokinetics of risperidone in extensive and poor metabolizers: The use of mixed effects modeling
    • Hossain M, Ette EI, Ludden TM. Pharmacokinetics of risperidone in extensive and poor metabolizers: the use of mixed effects modeling. J Clin Pharmacol 1994;34:1019.
    • (1994) J Clin Pharmacol , vol.34 , pp. 1019
    • Hossain, M.1    Ette, E.I.2    Ludden, T.M.3
  • 30
    • 0028270373 scopus 로고
    • Disposition of clozapine and desmethylclozapine in schizophrenic patients
    • Lin SK, Chang WH, Chung MC, Lam YW, Jann MW. Disposition of clozapine and desmethylclozapine in schizophrenic patients. J Clin Pharmacol 1994;34:318-24.
    • (1994) J Clin Pharmacol , vol.34 , pp. 318-324
    • Lin, S.K.1    Chang, W.H.2    Chung, M.C.3    Lam, Y.W.4    Jann, M.W.5
  • 32
    • 0027967725 scopus 로고
    • Plasma clozapine and haloperidol concentrations in adolescents with childhood-onset schizophrenia: Association with response
    • Piscitelli SC, Frazier JA, McKenna K, Albus KE, Grothe DR, Gordon CT, Rapoport JL. Plasma clozapine and haloperidol concentrations in adolescents with childhood-onset schizophrenia: association with response. J Clin Psychiatry 1994;55[suppl B]:94-7.
    • (1994) J Clin Psychiatry , vol.55 , Issue.SUPPL. B , pp. 94-97
    • Piscitelli, S.C.1    Frazier, J.A.2    McKenna, K.3    Albus, K.E.4    Grothe, D.R.5    Gordon, C.T.6    Rapoport, J.L.7
  • 33
    • 0026068791 scopus 로고
    • Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients
    • Perry P, Miller D, Arndt S, Cadoret R. Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients. Am J Psychiatry 1991;148:231-5.
    • (1991) Am J Psychiatry , vol.148 , pp. 231-235
    • Perry, P.1    Miller, D.2    Arndt, S.3    Cadoret, R.4
  • 35
    • 0028341606 scopus 로고
    • N-desmethylclozapine: A clozapine metabolite that suppresses haemopoiesis
    • Gerson SL, Arce C, Meltzer HY. N-desmethylclozapine: a clozapine metabolite that suppresses haemopoiesis. Br J Haematol 1994;86:555-61.
    • (1994) Br J Haematol , vol.86 , pp. 555-561
    • Gerson, S.L.1    Arce, C.2    Meltzer, H.Y.3
  • 36
    • 0026779165 scopus 로고
    • In vitro bioactivation of clozapine to a chemically reactive metabolite by human and mouse liver microsomes
    • Pirmohamed M, Templeton E, Breckenridge AM, Park BK. In vitro bioactivation of clozapine to a chemically reactive metabolite by human and mouse liver microsomes. Br J Clin Pharmacol 1992;35:168P.
    • (1992) Br J Clin Pharmacol , vol.35
    • Pirmohamed, M.1    Templeton, E.2    Breckenridge, A.M.3    Park, B.K.4
  • 37
    • 0028318482 scopus 로고
    • Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: Evidence from a therapeutic drug monitoring service
    • Jerling M, Lindstrom L, Bondesson U, Bertilsson L. Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: evidence from a therapeutic drug monitoring service. Ther Drug Monit 1994;16:368-74.
    • (1994) Ther Drug Monit , vol.16 , pp. 368-374
    • Jerling, M.1    Lindstrom, L.2    Bondesson, U.3    Bertilsson, L.4
  • 38
    • 0028298784 scopus 로고
    • Caffeine metabolism in a healthy Spanish population: N-acetylator phenotype and oxidation pathways
    • Carrillo JA, Benitez J. Caffeine metabolism in a healthy Spanish population: N-acetylator phenotype and oxidation pathways. Clin Pharmacol Ther 1994;55:293-304.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 293-304
    • Carrillo, J.A.1    Benitez, J.2
  • 39
    • 0027405998 scopus 로고
    • Clozapine and N-desmethylclozapine are potent 5-HT1c receptor antagonists
    • Kuoppamaki M, Syvalahti E, Hietala J. Clozapine and N-desmethylclozapine are potent 5-HT1c receptor antagonists. Eur J Pharmacol 1993;245:179-82.
    • (1993) Eur J Pharmacol , vol.245 , pp. 179-182
    • Kuoppamaki, M.1    Syvalahti, E.2    Hietala, J.3
  • 40
    • 0026091799 scopus 로고
    • The mechanism of action of novel atypical antipsychotic drugs
    • Meltzer H. The mechanism of action of novel atypical antipsychotic drugs, Schizophr Bull 1991;17:262-87.
    • (1991) Schizophr Bull , vol.17 , pp. 262-287
    • Meltzer, H.1
  • 41
    • 0003088549 scopus 로고
    • The mechanism of action of clozapine in relation to its clinical advantages
    • Meltzer H, ed. New York: Raven Press
    • Meltzer H. The mechanism of action of clozapine in relation to its clinical advantages. In: Meltzer H, ed. Novel antipsychotic drugs. New York: Raven Press, 1992:1-13.
    • (1992) Novel Antipsychotic Drugs , pp. 1-13
    • Meltzer, H.1
  • 42
    • 0016480950 scopus 로고
    • Bioanalytical assay of clozapine and its N-oxide metabolite and the determination of their blood levels in the dog
    • Meier J. Bioanalytical assay of clozapine and its N-oxide metabolite and the determination of their blood levels in the dog. Br J Pharmacol 1975;53:440P.
    • (1975) Br J Pharmacol , vol.53
    • Meier, J.1
  • 43
    • 0017663734 scopus 로고
    • Nonequilibrium method for the radioimmunoassay of clozapine in the presence of metabolites
    • Rosenthaler J, Nimmerfall F, Sigrist R, Munzer H. Nonequilibrium method for the radioimmunoassay of clozapine in the presence of metabolites. Eur J Biochem 1977;80:603-9.
    • (1977) Eur J Biochem , vol.80 , pp. 603-609
    • Rosenthaler, J.1    Nimmerfall, F.2    Sigrist, R.3    Munzer, H.4
  • 44
    • 0028174217 scopus 로고
    • Identification of clozapine N-glucuronide in the urine of patients treated with clozapine using electrospray mass spectrometry
    • Luo H, McKay G, Midha KK. Identification of clozapine N-glucuronide in the urine of patients treated with clozapine using electrospray mass spectrometry. Biol Mass Spectrom 1994;23: 147-8.
    • (1994) Biol Mass Spectrom , vol.23 , pp. 147-148
    • Luo, H.1    McKay, G.2    Midha, K.K.3
  • 48
    • 0015999247 scopus 로고
    • Antipsychotic efficacy of clozapine in correlation to changes in catecholamine metabolism in man
    • Forrest C, Carr J, Usdin E, eds. New York: Raven Press
    • Ackenheil M, Beckmann H, Greil W, Hoffmann G, Makianos E, Raese J. Antipsychotic efficacy of clozapine in correlation to changes in catecholamine metabolism in man. In: Forrest C, Carr J, Usdin E, eds. The phenothiazines and structurally related drugs. New York: Raven Press, 1974:647-57.
    • (1974) The Phenothiazines and Structurally Related Drugs , pp. 647-657
    • Ackenheil, M.1    Beckmann, H.2    Greil, W.3    Hoffmann, G.4    Makianos, E.5    Raese, J.6
  • 49
    • 9244229433 scopus 로고
    • Risperidone dose-proportionality in psychotic patients using a population pharmacokinetic analysis
    • Ghent, Belgium, April
    • Van Peer A, Gasparini R, Huang M, Woestenborghs E, Heykants J. Risperidone dose-proportionality in psychotic patients using a population pharmacokinetic analysis. Presented at the Clinical Pharmacological Meeting, Ghent, Belgium, April 1992.
    • (1992) Clinical Pharmacological Meeting
    • Van Peer, A.1    Gasparini, R.2    Huang, M.3    Woestenborghs, E.4    Heykants, J.5
  • 54
    • 0022390883 scopus 로고
    • In vitro inhibition studies of two isozymes of human liver cytochrome P-450: Mephenytoin p-hydroxylase and sparteine monooxygenase
    • Inaba T, Jurima M, Mahon W, Kalow W. In vitro inhibition studies of two isozymes of human liver cytochrome P-450: mephenytoin p-hydroxylase and sparteine monooxygenase. Drug Metab Dispos Biol Fate Chem 1985;13:443-8.
    • (1985) Drug Metab Dispos Biol Fate Chem , vol.13 , pp. 443-448
    • Inaba, T.1    Jurima, M.2    Mahon, W.3    Kalow, W.4
  • 55
    • 0026666976 scopus 로고
    • The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome p450 2D6
    • Fischer V, Vogels B, Maurer G, Tynes R. The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome p450 2D6. J Pharmacol Exp Ther 1992;260:1355-60.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 1355-1360
    • Fischer, V.1    Vogels, B.2    Maurer, G.3    Tynes, R.4
  • 58
    • 0026078295 scopus 로고
    • Effect of phenytoin on plasma clozapine concentrations in two patients
    • Miller D. Effect of phenytoin on plasma clozapine concentrations in two patients. J Clin Psychiatry 1991;52:23-5.
    • (1991) J Clin Psychiatry , vol.52 , pp. 23-25
    • Miller, D.1
  • 59
    • 0029133057 scopus 로고
    • Probable pharmacokinetic interaction between risperidone and clozapine
    • Tyson SC, DeVane CL, Risch SC. Probable pharmacokinetic interaction between risperidone and clozapine. Am J Psychiatry 1995;152:1401-2.
    • (1995) Am J Psychiatry , vol.152 , pp. 1401-1402
    • Tyson, S.C.1    DeVane, C.L.2    Risch, S.C.3
  • 62
    • 0028925217 scopus 로고
    • Improved efficacy and fewer side effects under clozapine treatment after addition of fluvoxamine
    • Szegedi A, Wiesner J, Hiemke C. Improved efficacy and fewer side effects under clozapine treatment after addition of fluvoxamine. J Clin Psychopharmacol 1995;15:141-3.
    • (1995) J Clin Psychopharmacol , vol.15 , pp. 141-143
    • Szegedi, A.1    Wiesner, J.2    Hiemke, C.3
  • 65
    • 0027740188 scopus 로고
    • Relationship between clinical efficacy and clozapine concentrations in plasma in schizophrenia: Effect of smoking
    • Hasegawa M, Gutierrez-Esteinou R, Way L, Meltzer H. Relationship between clinical efficacy and clozapine concentrations in plasma in schizophrenia: effect of smoking. J Clin Psychopharmacol 1993;13:383-90.
    • (1993) J Clin Psychopharmacol , vol.13 , pp. 383-390
    • Hasegawa, M.1    Gutierrez-Esteinou, R.2    Way, L.3    Meltzer, H.4
  • 68
    • 0027937972 scopus 로고
    • Plasma clozapine concentrations as a predictor of clinical response: A follow-up study
    • Miller D, Fleming F, Holman T, Perry P. Plasma clozapine concentrations as a predictor of clinical response: a follow-up study. J Clin Psychiatry 1994;55[suppl B]:117-21.
    • (1994) J Clin Psychiatry , vol.55 , Issue.SUPPL. B , pp. 117-121
    • Miller, D.1    Fleming, F.2    Holman, T.3    Perry, P.4
  • 69
    • 0026704942 scopus 로고
    • Clozapine concentrations and clinical response in schizophrenic patients
    • Owen JA, Delva NJ, Lawson JS. Clozapine concentrations and clinical response in schizophrenic patients. Am J Psychiatry 1992; 149:1120-1.
    • (1992) Am J Psychiatry , vol.149 , pp. 1120-1121
    • Owen, J.A.1    Delva, N.J.2    Lawson, J.S.3
  • 73
    • 0026643193 scopus 로고
    • Clozapine, single photon emission tomography, and the D2 dopamine receptor blockade hypothesis of schizophrenia
    • Pilowsky LS, Costa DC, Ell PJ, Murray RM, Verhoeff NPLG, Kerwin RW. Clozapine, single photon emission tomography, and the D2 dopamine receptor blockade hypothesis of schizophrenia. Lancet 1992;340:199-202.
    • (1992) Lancet , vol.340 , pp. 199-202
    • Pilowsky, L.S.1    Costa, D.C.2    Ell, P.J.3    Murray, R.M.4    Verhoeff, N.P.L.G.5    Kerwin, R.W.6
  • 74
    • 0026718710 scopus 로고
    • Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine
    • Farde L, Nordstrom AL, Wiesel FA, Pauli S, Halldin C, Sedvall G. Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Arch Gen Psychiatry 1992;49:538-44.
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 538-544
    • Farde, L.1    Nordstrom, A.L.2    Wiesel, F.A.3    Pauli, S.4    Halldin, C.5    Sedvall, G.6
  • 78
    • 0028342655 scopus 로고
    • Risperidone in the treatment of schizophrenia
    • Marder SR, Meibach R. Risperidone in the treatment of schizophrenia Am J Psychiatry 1994;151:825-35.
    • (1994) Am J Psychiatry , vol.151 , pp. 825-835
    • Marder, S.R.1    Meibach, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.