Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia

Human Genetics

Volumn 97, Issue 6, 1996, Pages 714-719

  Shaikh, Sanober ^a   Collier, David A ^a   Sham, Pak C ^a   Ball, David ^a   Aitchison, Katherine ^a   Vallada, Homero ^a   Smith, Iain ^b   Gill, Michael ^c   Kerwin, Robert W ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GARTNAVEL ROYAL HOSPITAL   (United Kingdom)

^c ST JAMES S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; DOPAMINE 3 RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CONGENITAL DISORDER; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG RESPONSE; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; META ANALYSIS; PRIORITY JOURNAL; RECEPTOR GENE; SCHIZOPHRENIA;

EID: 0030005962     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02346178     Document Type: Article

References (24)

1. Asherson P, Owen M (1995) Polymorphisms within the D3 receptor gene: is there an association with schizophrenia? Psychiatr Genet 5:S13
2. Buckland PR, O'Donovan MC, McGuffin P (1993) Clozapine and sulpiride up-regulate dopamine D3 receptor mRNA levels. Neuropharmacology 32:901-907
3. Crocq MA, Mant R, Asherson P, Williamson J, Hode Y, Mayerova A, Collier D, Lannfelt L, Sokoloff P, Gill M, Macher JP, McGuffin P, Owen MJ (1992) Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J Med Genet 29:858-860
4. Crocq MA, Griffon N, Pilon C, Martres MP, Mayerova A, Uyanic G, Bergert E, Duval F, Mokrani MC, Macher JP, Schwartz JC, Sokoloff P (1995) The human D3 receptor gene: structure transcript variants and polymorphisms. Psychiatr Genet 5:S99
5. Dean J, Dean A, Burton A, Dicker R (1990) Epi Info, version 5.0. Centres for disease control. Epidemiology Office, Atlanta, Georgia
6. Di Bella D, Catalano M, Strukel M, Nobile M, Novelli E, Smeraldi E (1994) Distribution of the MscI polymorphism of the dopamine D3 receptor in an Italian psychotic population. Psychiatr Genet 4:39-42
7. Egger M, Smith GD (1995) Misleading meta-analysis. Br Med J 310:752-754
8. Endicott J, Spitzer RL, Fleiss JL, Cohen J (1976) The global assessment scale. Arch Gen Psychiatry 33:766-771
9. Jönsson E, Lannfelt L, Sokoloff P, Schwartz JC, Sedvall G (1993) Lack of association between schizophrenia and alleles at the D3 receptor gene. Acta Psychiatr Scand 87:345-349
10. Kolakowska T, Williams AO, Ardern M, Reveley MA, Jambor K, Gelder MG, Mandelbrote BM (1985) Schizophrenia with good and poor outcome I. Early clinical features, response to neuroleptics and signs of organic dysfunction. Br J Psychiatry 146: 229-246
11. Lannfelt L, Sokoloff P, Martres MP, Pilon C, Giros B, Jonnson E, Sedvall G, Schwartz JC (1992) Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders. Psychiatr Genet 2:249-256
12. Laurent C, Savoye C, Samolyk D, Mallet J (1994) Homozygosity at the dopamine D3 receptor locus is not associated with schizophrenia. J Med Genet 31:260
13. Mant R, Williams J, Asherson P, Parfitt E, McGuffin P, Owen MJ (1994) Relationship between homozygosity at the dopamine D3 receptor gene and schizophrenia. Am J Med Genet 54:21-26
14. Meltzer H (1992) Dimensions of outcome with clozapine. Br J Psychiatry 160 [Suppl 17]:46-53
15. Nanko S, Sasaki T, Fukuda R, Hattori M, Dai XY, Kazamatsuri H, Kuwata S, Juji T, Gill M (1993) A study of the association between schizophrenia and the dopamine D3 receptor gene. Hum Genet 92:336-338
16. Nimgaonkar VL, Zhang XR, Caldwell JG, Ganguli R, Chakravati A (1993) Association study of schizophrenia with dopamine D3 receptor gene polymorphism: probable effect of family history of schizophrenia? Am J Med Genet 48:214-217
17. Nöthen MM, Cichon S, Propping P, Fimmers R, Schwab SG, Wildenauer DB (1993) Excess of homozygosity at the dopamine D3 receptor gene in schizophrenia not confirmed. J Med Genet 30: 708
18. Saha N, Tsoi WF, Low PS, Basair J, Tay JSH (1994) Lack of association of the dopamine D3 receptor gene polymorphism (BalI) in Chinese schizophrenic males. Psychiatr Genet 4:201-204
19. Seeman (1992) Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4. Neuropsychopharmacology 7:261-283
20. Shaikh S, Collier D, Kerwin RW, Pilowsky L, Gill M, Xu W, Thornton A (1993) Dopamine D4 receptor subtypes and response to clozapine. Lancet 341:116
21. Sokoloff P, Giros B, Martres M-P, Bouthernet M-L, Schwartz J-L (1990) Molecular cloning and characterisation of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347: 146-151
22. Sokoloff P, Lannfelt L, Martres MP, Giros B, Bouthernet M-L, Schwartz JC (1992) The third dopamine receptor (D3) as a novel target for antipsychotics. Biochem Pharmacol 43:659-666
23. Van Tol HHM, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O (1991) Cloning of the gene for the human D4 receptor with high affinity for the antipsychotic clozapine. Nature 530:610-619
24. Yang L, Weise C, Lannfelt L, Sokoloff P, Xu CT, Zeng Z, Schwartz C, Lui X, Moises HW (1993) No association between schizophrenia and homozygosity at the D3 dopamine receptor gene. Am J Med Genet 48:83-86