Genetic heterogeneity in hereditary breast cancer: Role of BRCA1 and BRCA2

American Journal of Human Genetics

Volumn 59, Issue 3, 1996, Pages 547-553

  Rebbeck, T R ^a,c   Couch, F J ^a   Kant, J ^a   Calzone, K ^a   Deshano, M ^a   Peng, Y ^a   Chen, K ^a   Garber, J E ^b   Weber, B L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST CANCER; CANCER SUSCEPTIBILITY; CHROMOSOME 13Q; DISEASE PREDISPOSITION; FAMILIAL CANCER; FEMALE; GENE MUTATION; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC MARKER; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ADULT; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; GENETIC HETEROGENEITY; GENETIC MARKERS; HUMANS; LINKAGE (GENETICS); MALE; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; NORTH AMERICA; OVARIAN NEOPLASMS; PEDIGREE; TRANSCRIPTION FACTORS;

EID: 0029767672     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Buller RE, Anderson B, Connor JP, Robinson R (1993) Familial ovarian cancer. Gynecol Oncol 51:160-166
2. Castilla LH, Couch FJ, Erdos MR, Hoskins KF, Calzone K, Garber JE, Boyd J, et al (1994) Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. Nat Genet 8:387-391
3. Spurr NK, Kelsell DP, Mavrakis E, Bryant SP, Crockford G, Bishop DT (1995) Genetic heterogeneity in United Kingdom breast and ovarian cancer families. Am J Hum Genet Suppl 57:A5
4. Weeks DE, Ott J, Lathrop GM (1990) SLINK: a general simulation program for linkage analysis. Am J Hum Genet Suppl 47:A204
5. Wooster R, Neuhausen S, Mangion J, Quirk Y, Ford D, Collins N, Nguyen K, et al (1994) Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13ql2-13. Science 265:2088-2090