Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction

Molecular Immunology

Volumn 34, Issue 3, 1997, Pages 221-226

  Exley, Mark ^a   Varticovski, Lyuba ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Phosphatidylinositol 3 kinase; T cell; TCR; Wortmannin

Indexed keywords

CD28 ANTIGEN; PHORBOL ESTER; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; WORTMANNIN;

ANTIGEN PRESENTING CELL; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; CELL LINE; ENZYME INHIBITORS; HUMANS; LYMPHOCYTE ACTIVATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PHOSPHOTYROSINE; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 0030848134     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00027-8     Document Type: Article

References (33)

1. Aagaard-Tillery K. and Jelinek D. (1996) A role for PI 3-kinase in generating T cell help for B cell growth and differentiation. J. Immunol. 157, 2769-2778.
2. Cambier J. (1995) Antigen and Fc receptor signalling. J. Immunol. 155, 3281-3285.
3. Cantley L., Auger K., Carpenter C., Duckworth B., Graziani A., Kapeller R. and Soltoff S. (1991) Oncogenes and signal transduction. Cell 64, 281-302.
4. Carrera A., Rodriguez-Borlado L., Matinez-Alonso C. and Merida I. (1994) TCR-associated PI 3-kinase becomes activated by TCR crosslinking and requires pp561ck. J. Biol. Chem. 269, 19435-19440.
5. Claesson M., Dissing S., Tscheming T. and Geisler C. (1992) Anti-major histocompatibility complex class 1 antibody-induced activation and clonal abortion in Jurkat T leukemic cells. Immunology 78, 444-448.
6. 2 activation and arachidonic acid release. Biochem. Soc. Trans. 21, 496S.
7. Cross M., Stewart A., Hodgkin M., Kerr D. and Wakelam M. (1995) WM and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity. J. Biol. Chem. 270, 25352-25355.
8. Exley M., Varticovski L., Peter M., Sancho J. and Terhorst C. (1994) Association of PI 3-kinase with a specific motif in the T cell receptor ζ chain upon T cell activation. J. Biol. Chem. 269, 15140-15146.
9. Flaswinkel H., Barner M. and Reth M. (1995) The Tyr-activation motif as a target for protein Tyr kinases and SH2 domains. Semin. Immunol. 7, 21-27.
10. Fukazawa T., Reedquist K., Panchamoorthy G., Soltoff S., Trub D., Drucker B., Cantley L., Shoelson S. and Band H. (1995) T cell activation-dependent association between the p85 subunit of PI 3-kinase and Grb-2/phospholipase C γ1-binding phosphotyrosyl protein pp36/38. J. Biol. Chem 270, 20177-20182.
11. Huang X., Li Y., Tanaka K., Moore K. and Hayashi J. (1995) Cloning and characterization of Lnk, a signal transduction protein that links T cell receptor activation signal to phospholipase Cy1, Grb-2, and PI 3-kinase. Proc. natn. Acad. Sci. U.S.A. 92, 11618-11622.
12. Hutchcroft J. and Bierer B. (1996) Signaling through CD28/CTLA-4 family receptors. J. Immunol. 157, 4071-4074.
13. Jouvin M., Numerof R. and Kinet J. -P. (1995) Signal transduction through the conserved motifs of the high affinity IgE receptor FceR1. Semin. Immunol. 7, 29-35.
14. Kanazawa T., Keeler M. and Varticovski L. (1994) Serine rich region of the IL-2 receptor β-chain is required for activation of PI 3-kinase. Cell. Immunol. 156, 378-388.
15. Lam K., Carpenter C., Ruderman N., Friel J. and Kelly K. (1994) The PI 3-kinase serine kinase phosphorylates IRS1: stimulation by insulin and inhibition by WM. J. Biol. Chem. 269, 20648-20652.
16. Meisner H., Conway B., Hartley D. and Czech M. (1995) Interactions of Cb1 with Grb-2 and PI 3-kinase in activated Jurkat cells. Mol. Cell. Biol. 15, 3571-3578.
17. Nakanishi S., Catt K. and Balla T. (1995) A wortmanninsensitive PI 4-kinase that regulates hormone-sensitive pools of inositolphospholipids. Proc. natn. Acad. Sci. U.S.A. 92, 5317-5321.
18. Perlmutter R., Levin S., Appleby M., Anderson S. and Alberola-Ila J. (1993) Regulation of lymphocyte function by protein phosphorylation. Ann. Rev. Immunol. 11, 451-499.
19. Ravichandran K., Lee K., Songyang Z., Cantley L., Burn P. and Burakoff S. (1993) Interaction of She with the ζ chain of the T cell receptor upon T cell activation. Science 262, 902.
20. Remillard B., Petrillo R., Maslinski W., Tsudo M., Strom T., Cantley L. and Varticovski L. (1991) IL-2 receptor regulates activation of PI 3-kinase. J. Biol. Chem. 266, 14167-14173.
21. Reth M. (1994) B cell antigen receptors. Curr. Opin. Immunol. 6, 3-8.
22. Rudd C. (1996) Upstream-downstream: CD28 cosignaling pathways and T cell function. Immunity 4, 527-534.
23. Rudd C., Janssen O., Cai Y., daSilva A., Raab M. and Prasad K. (1994) Two step TCR-ζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein tyrosine and lipid kinases. Immunol. Today 15, 225-234.
24. Samelson L. and Klausner R. (1992) Tyrosine kinases and tyrosine-based activation motifs. J. Biol. Chem. 267, 24913-24916.
25. Terhorst, C., Spits, H., Staal, F. and Exley, M. (1996) T lymphocyte signal transduction. In Molecular Immunology, 2nd Edition (Edited by Glover D. and Hames D.), pp. 132-188. Oxford University Press, Oxford.
26. Thompson P., Gutkind J., Robbins K., Ledbetter J. and Bolen J. (1992) Identification of distinct subpopulations of PI 3-kinase activity following T cell activation. Oncogene 7, 719-725.
27. Ueda Y., Levine B., Huang M., Freeman G., Nadler L., June C. and Ward S. (1995) Both CD28 ligands B7-1 and B7-2 activate PI 3-kinase; WM reveals heterogeneity in the regulation of T cell IL-2 secretion. Int. Immunol. 7, 957-966.
28. Varticovski L., Drucker B., Morrison D., Cantley L. and Roberts T. (1989) The colony stimulating factor-1 receptor associates with and activates PI 3-kinase. Nature 342, 699-703.
29. Wange R. and Samelson L. (1996) Signaling at the TCR. Immunity 5, 197-205.
30. Ward S., Ley S., MacPhee C. and Cantrell D. (1992) Regulation of D-3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens. Eur. J. Immunol. 22, 45-49.
31. Ward S., Wilson A., Turner L., Westwick J. and Sansom D. (1995) Inhibition of CD28-mediated costimulation by the PI 3-kinase inhibitor WM. Eur. J. Immunol. 25, 526-532.
32. Ward S., June C. and Olive D. (1996) PI 3-kinase: pivotal pathway in T cell activation. Immunol. Today 17, 187-197.
33. Weiss A. and Littman D. (1994) Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274.