Wortmannin, a Phosphatidylinositol 3-Kinase Inhibitor, Blocks Antigen-Mediated, but Not CD3 Monoclonal Antibody-Induced, Activation of Murine CD4+ T Cells

Journal of Immunology

Volumn 158, Issue 10, 1997, Pages 4688-4695

  Shi, Jia ^a   Cinek, Tomas ^a,b   Truitt, Kenneth E ^a   Imboden, John B ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANE DERIVATIVE; B7 ANTIGEN; CD3 ANTIGEN; ENZYME INHIBITOR; INTERLEUKIN 2; INTERLEUKIN 4; LYMPHOCYTE ANTIGEN RECEPTOR; OVALBUMIN; PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; WORTMANNIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; ANTIGENS, CD3; ANTIGENS, CD80; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; ENZYME INHIBITORS; INTERLEUKIN-2; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; MICE; MICE, TRANSGENIC; OVALBUMIN; PEPTIDES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 0031570038     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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