Structural plasticity in a remodeled protein-protein interface

Science

Volumn 278, Issue 5340, 1997, Pages 1125-1128

  Atwell, Shane ^a,b   Ultsch, Mark ^a   De Vos, Abraham M ^a   Wells, James A ^a,b  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BINDING AFFINITY; GENE DELETION; GENE REARRANGEMENT; NERVE CELL PLASTICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; HUMAN GROWTH HORMONE; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MUTAGENESIS; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0030707656     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5340.1125     Document Type: Article

References (35)

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35. S.A. was supported in part by a NIH Biotechnology Training Grant. We thank the oligonucleotide synthesis and fermentation groups at Genentech; T. Clackson for providing samples of hGHbp and W104A-hGHbp; M. Randal and T. Kossiakoff for help with x-ray data collection; and W. DeLano for help with intermolecular distance calculations. X-ray coordinates have been deposited in the Protein Data Bank with access number 1AXI.